Journal of the Korean Academy of Child and Adolescent Psychiatry

대한소아청소년정신의학회 (Korean Academy of Child and Adolescent Psychiatry)
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What Event-Related Potential Tells Us about Brain Function: Child-Adolescent Psychiatric Perspectives

  • Kim, Ji Sun (Department of Psychiatry, Soonchunhyang University Cheonan Hospital, Soonchunhyang University College of Medicine) ;
  • Lee, Yeon Jung (Department of Psychiatry, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine) ;
  • Shim, Se-Hoon (Department of Psychiatry, Soonchunhyang University Cheonan Hospital, Soonchunhyang University College of Medicine)
  • 투고 : 2021.04.23
  • 심사 : 2021.05.21
  • 발행 : 2021.07.01
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초록

Electroencephalography (EEG) measures neural activation due to various cognitive processes. EEG and event-related potentials (ERPs) are widely used in studies investigating psychopathology and neural substrates of psychiatric diseases in children and adolescents. The present study aimed to review recent ERP studies in child and adolescent psychiatry. ERPs are non-invasive methods for studying synaptic functions in the brain. ERP might be a candidate biomarker in child-adolescent psychiatry, considering its ability to reflect cognitive and behavioral functions in humans. For the EEG study of psychiatric diseases in children and adolescents, several ERP components have been used, such as mismatch negativity, P300, error-related negativity (ERN), and reward positivity (RewP). Regarding executive functions and inhibition in patients with attention-deficit/hyperactivity disorder (ADHD), P300 latency, and ERN were significantly different in patients with ADHD compared to those in the healthy population. ERN showed meaningful changes in patients with anxiety disorders, such as generalized anxiety disorder, separation anxiety disorder, and obsessive-compulsive disorder. Patients with depression showed significantly attenuated RewP compared to the healthy population, which was related to the symptoms of anhedonia.

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과제정보

This work was supported by a grant (2020R1I1A3068017) awarded by the Basic Science Research Program through the National Research Foundation of Korea (NRF) and funded by the Ministry of Education. This work was also supported by a grant (2020R1I1A3A04036435) awarded by the Basic Science Research Program through the National Research Foundation of Korea (NRF) and funded by the Ministry of Education.

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