Journal of Yeungnam Medical Science

영남대 의대 학술지 편집위원회 (Yeungnam University College of Medicine, Yeungnam University Institute Medical Science)
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Metachronous extranodal natural killer/T-cell lymphoma of nasal type and primary testicular lymphoma

  • Maeng, Young-In (Department of Pathology, Daegu Catholic University School of Medicine) ;
  • Lee, Sun-Jae (Department of Pathology, Daegu Catholic University School of Medicine)
  • 투고 : 2020.07.24
  • 심사 : 2020.08.18
  • 발행 : 2021.07.31
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초록

We report a rare case of metachronous lymphoma with two distinct cell lineages in a 75-year-old man. The patient complained about having nasal obstruction for 2 years and extranodal natural killer (NK)/T-cell lymphoma of the nasal type was diagnosed from a biopsy. The immunohistochemical staining for CD56 and in situ hybridization for Epstein-Barr virus (EBV)-encoded small RNA (EBER-ISH) were positive and the tumor cells were negative for CD20. After 13 months of concurrent chemoradiotherapy, the patient presented with swelling of the left testis. Positron emission tomography scan detected an abnormal uptake in the testis. A diffuse large B-cell lymphoma, not otherwise specified, was diagnosed from subsequent radical orchiectomy. The immunohistochemical staining revealed to be positive for CD20, BCL2, BCL6, and MYC and negative for CD10 and EBER-ISH.

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참고문헌

  1. Moller MB, d'Amore F, Christensen BE; Danish Lymphoma Study Group. Testicular lymphoma: a population-based study of incidence, clinicopathological correlations and prognosis. Eur J Cancer 1994;30:1760-4. https://doi.org/10.1016/0959-8049(94)00311-R
  2. Chan JK, Quintanilla-Martinez L, Ferry JA. Extrannodal NK/T-cell lymphoma, nasal type. In: Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, et al., editors. WHO classification of tumours of haematopoietic and lymphoid tissues. 4th ed. Lyon: IARC Press; 2017. p. 368-71.
  3. Pileri SA, Weisenburger DD, Sng I, Nakamura S, Muller-Hermelink HK, Chan WC, et al. Peripheral T-cell lymphoma, NOS. In: Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, et al., editors. WHO classification of tumours of haematopoietic and lymphoid tissues. 4th ed. Lyon: IARC Press; 2017. p. 403-6.
  4. King RL, Goodlad JR, Calaminici M, Dotlic S, Montes-Moreno S, Oschlies I, et al. Lymphomas arising in immune-privileged sites: insights into biology, diagnosis, and pathogenesis. Virchows Arch 2020;476:647-65. https://doi.org/10.1007/s00428-019-02698-3
  5. Booman M, Douwes J, Glas AM, de Jong D, Schuuring E, Kluin PM. Primary testicular diffuse large B-cell lymphomas have activated B-cell-like subtype characteristics. J Pathol 2006;210: 163-71. https://doi.org/10.1002/path.2033
  6. Cheah CY, Wirth A, Seymour JF. Primary testicular lymphoma. Blood 2014;123:486-93. https://doi.org/10.1182/blood-2013-10-530659
  7. Brunn A, Nagel I, Montesinos-Rongen M, Klapper W, Vater I, Paulus W, et al. Frequent triple-hit expression of MYC, BCL2, and BCL6 in primary lymphoma of the central nervous system and absence of a favorable MYC(low)BCL2 (low) subgroup may underlie the inferior prognosis as compared to systemic diffuse large B cell lymphomas. Acta Neuropathol 2013; 126:603-5. https://doi.org/10.1007/s00401-013-1169-7
  8. Fonseca R, Habermann TM, Colgan JP, O'Neill BP, White WL, Witzig TE, et al. Testicular lymphoma is associated with a high incidence of extranodal recurrence. Cancer 2000;88:154-61. https://doi.org/10.1002/(SICI)1097-0142(20000101)88:1<154::AID-CNCR21>3.0.CO;2-T