Journal of Yeungnam Medical Science

영남대 의대 학술지 편집위원회 (Yeungnam University College of Medicine, Yeungnam University Institute Medical Science)
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Sciatic nerve neurolymphomatosis as the initial presentation of primary diffuse large B-cell lymphoma: a rare cause of leg weakness

  • Kim, Kyoung Tae (Department of Rehabilitation Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine) ;
  • Kim, Se Il (Department of Rehabilitation Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine) ;
  • Do, Young Rok (Department of Internal Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine) ;
  • Jung, Hye Ra (Department of Pathology, Keimyung University Dongsan Hospital, Keimyung University School of Medicine) ;
  • Cho, Jang Hyuk (Department of Rehabilitation Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine)
  • 투고 : 2021.02.08
  • 심사 : 2021.03.05
  • 발행 : 2021.07.31
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초록

Neurolymphomatosis (NL) is defined as the involvement of the peripheral nervous system in lymphocytic invasion. It is a very rare form of lymphoma that may occur as an initial presentation or recurrence. It affects various peripheral nervous structures and can therefore mimic disc-related nerve root pathology or compressive mononeuropathy. NL often occurs in malignant B-cell non-Hodgkin lymphomas. Notwithstanding its aggressiveness or intractability, NL should be discriminated from other neurologic complications of lymphoma. Herein, we present a case of primary NL as the initial presentation of diffuse large B-cell lymphoma (DLBCL) of the sciatic nerve. The patient presented with weakness and pain in his left leg but had no obvious lesion explaining the neurologic deficit on initial lumbosacral and knee magnetic resonance imaging (MRI). NL of the left sciatic nerve at the greater sciatic foramen was diagnosed based on subsequent hip MRI, electrodiagnostic test, positron emission tomography/computed tomography, and nerve biopsy findings. Leg weakness slightly improved after chemotherapy and radiotherapy. We report a case wherein NL, a rare cause of leg weakness, manifested as the initial presentation of primary DLBCL involving the sciatic nerve at the greater sciatic foramen.

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참고문헌

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