DOI QR코드

DOI QR Code

A Case of the Therapeutic Effect of Nangan-jeon on Refractory Functional Dyspepsia Caused by "Liver-Kidney Deficiency Cold"

  • Son, Chang-gue (Liver and Immunology Research Center, Oriental Medical College in Daejeon University)
  • 투고 : 2021.05.12
  • 심사 : 2021.06.21
  • 발행 : 2021.06.30

초록

Objective: This study explored the clinical usefulness of Nangan-jeon decoction to treat refractory functional dyspepsia. Methods: A 61-year-old female had been suffering from severe functional dyspepsia for about 40 years, but the dyspeptic symptoms rapidly improved after taking Nangan-jeon decoction. The clinical outcome was assessed by the numerical rating scale (NRS) and the self-reporting method. Result: After there was no improvement from various herbal treatments in a department of a Korean college hospital, the patient moved to the author's clinic. She had been diagnosed with the pattern identification of "liver-kidney deficiency cold" and prescribed with Nangan-jeon decoction. This herbal drug rapidly improved her dyspeptic symptoms, from NRS 10 to NRS 2 (after 3 weeks) and NRS 1 (after 7 weeks). Conclusion: This case report is the first to present the potential of Nangan-jeon decoction to improve refractory functional dyspepsia.

키워드

참고문헌

  1. Stanghellini V, Chan FK, Hasler WL, Malagelada JR, Suzuki H, Tack J, et al. Gastroduodenal disorders. Gastroenterology 2016;150(5):1380-92. https://doi.org/10.1053/j.gastro.2016.02.011
  2. Mahadeva S, Goh KL. Epidemiology of functional dyspepsia: a global perspective. World J Gastroenterol 2006;12(17):2661-6. https://doi.org/10.3748/wjg.v12.i17.2661
  3. Jung HK, Keum BR, Jo YJ, Jee SR, Rhee PL, Kang YW, et al. Diagnosis of functional dyspepsia: a systematic review. Korean J Gastroenterol 2010;55(5):296-307. https://doi.org/10.4166/kjg.2010.55.5.296
  4. Stanghellini V, Chan FKL, Hasler WL, Malagelada JR, Suzuki H, Tack J, et al. Gastroduodenal disorders. Gastroenterol 2016;150(6):1380-92. https://doi.org/10.1053/j.gastro.2016.02.011
  5. Suzuki H. The Application of the Rome IV Criteria to Functional Esophagogastroduodenal Disorders in Asia. J Neurogastroenterol Motil 2017;23(3):325-33. https://doi.org/10.5056/jnm17018
  6. Talley N, Walker M. Emerging evidence that irritable bowel syndrome & functional dyspepsia are microbial diseases. Indian J Med Res 2019;149(4):437-40. https://doi.org/10.4103/ijmr.IJMR_84_19
  7. El-Serag HB, Talley NJ. Health-related quality of life in functional dyspepsia. Aliment Pharmacol Ther 2003;18(4):387-93. https://doi.org/10.1046/j.1365-2036.2003.01706.x
  8. Tack J, Camilleri M. New developments in the treatment of gastroparesis and functional dyspepsia. Curr Opin Pharmacol 2018;43:111-7. https://doi.org/10.1016/j.coph.2018.08.015
  9. Lacy BE, Talley NJ, Locke GR, Bouras EP, DiBaise JK, El-Serag HB, et al. Review article: current treatment options and management of functional dyspepsia. Aliment Pharmacol Ther 2012;36(1):3-15. https://doi.org/10.1111/j.1365-2036.2012.05128.x
  10. Chiarioni G, Pesce M, Fantin A, and Sarnelli G. Complementary and alternative treatment in functional dyspepsia. United Eur Gastroenterol J 2018;6(1):5-12. https://doi.org/10.1177/2050640617724061
  11. Kim SK, Joung JY, Ahn YC, Jung IC, Son CG. Beneficial Potential of Banha-Sasim-Tang for Stress-Sensitive Functional Dyspepsia via Modulation of Ghrelin: A Randomized Controlled Trial. Front Pharmacol 2021;12:636752. https://doi.org/10.3389/fphar.2021.636752
  12. Tominaga K, Sakata Y, Kusunoki H, Odaka T, Sakurai K, Kawamura O, et al. Rikkunshito simultaneously improves dyspepsia correlated with anxiety in patients with functional dyspepsia: A randomized clinical trial (the DREAM study). Neurogastroenterol Motil 2018;30(7):e13319. https://doi.org/10.1111/nmo.13319
  13. Jiang SM, Jia L, Lei XG, Xu M, Wang SB, Liu J, et al. Incidence and psychological-behavioral characteristics of refractory functional dyspepsia: a large, multi-center, prospective investigation from China. World J Gastroenterol 2015;21(6):1932-7. https://doi.org/10.3748/wjg.v21.i6.1932
  14. Zheng H, Xu J, Sun X, Zeng F, Li Y, Wu X, et al. Electroacupuncture for patients with refractory functional dyspepsia: A randomized controlled trial. Neurogastroenterol Motil 2018;30(7):e13316. https://doi.org/10.1111/nmo.13316
  15. Hartrick CT, Kovan JP, Shapiro S. The numeric rating scale for clinical pain measurement: a ratio measure? Pain Pract 2003;3(4):310-6. https://doi.org/10.1111/j.1530-7085.2003.03034.x
  16. Kim YS, Kim N. Functional Dyspepsia: A Narrative Review with a Focus on Sex-Gender Differences. J Neurogastroenterol Motil 2020;26(3):322-34. https://doi.org/10.5056/jnm20026
  17. Kim YJ, Ahn YC, Son CG. Sasang constitution affects the prevalence of functional dyspepsia. BMC Complement Altern Med 2015;15:150. https://doi.org/10.1186/s12906-015-0674-8
  18. Kim SE, Kim N, Park SM, Kim WH, Baik GH, Jo Y, et al. Female gender is a poor predictive factor of functional dyspepsia resolution after Helicobacter pylori eradication: A Prospective, Multi-center Korean Trial. Korean J Gastroenterol 2018;72(6):286-94. https://doi.org/10.4166/kjg.2018.72.6.286
  19. Hamilton J, Guthrie E, Creed F, Thompson D, Tomenson B, Bennett R, et al. A randomized controlled trial of psychotherapy in patients with chronic functional dyspepsia. Gastroenterology 2000;119(3):661-9. https://doi.org/10.1053/gast.2000.16493
  20. Kim SE, Park HK, Kim N, Joo YE, Baik GH, Shin JE, et al. Prevalence and risk factors of functional dyspepsia: a nationwide multicenter prospective study in Korea. Prospective, Multi-center Korean Trial. J Clin Gastroenterol 2014;48(2):e12-8.
  21. Kim JB, Shin JW, Kang JY, Son CG, Kang W, Lee HW, et al. A traditional herbal formula, Hyangsa-Pyeongwi san (HPS), improves quality of life (QoL) of the patient with functional dyspepsia (FD): randomized double-blinded controlled trial. J Ethnopharmacol 2014;151(1):279-86. https://doi.org/10.1016/j.jep.2013.10.033
  22. Lv L, Wang FY, Ma XX, Li ZH, Huang SP, Shi ZH, et al. Efficacy and safety of Xiangsha Liujunzi granules for functional dyspepsia: A multi-center randomized double-blind placebo-controlled clinical study. World J Gastroenterol 2017;23(30):5589-601. https://doi.org/10.3748/wjg.v23.i30.5589
  23. Ha NY. Development of Standard Tool for Pattern Identification of Functional Dyspepsia and Analysis of its Clinical Characterization. Graduate School of Korean Medicine, Kyung Hee University, PhD's thesis 2020.
  24. He J, Huang M, Zhang Q, Liao W, Wang L, Zhang Y. Treatment of unstable angina pectoris with modified nuan gan jian - a report of 33 cases. J Tradit Chin Med 2004;24(4):263-5. https://doi.org/10.3969/j.issn.0255-2922.2004.04.006
  25. Lee SH, Lee YH. Case Reports of Treatment of Nangan-jeon for Female Infertility. J Naturopathy 2013;2(1):83-8.
  26. Lee SH. Influences of Gagamanganjeon and Grain Syrup on the Infertile Women with Symptoms of Liver-Kidney-Cool Types. J Naturopathy 2014;4(1):88-98.
  27. Yang JM, Li G, Wang M, Jin YX, Zheng FJ, Sun Y, et al. The Effects of Natural Chinese Medicine Aconite Root, Dried Ginger Rhizome, and Coptis on Rectal and Skin Temperatures at Acupuncture Points. Evid Based Complement Alternat Med 2017;2017:7250340.
  28. Chung VC, Wong CH, Wu IX, Ching JY, Cheung WK, Yip BH, et al. Electroacupuncture plus on-demand gastrocaine for refractory functional dyspepsia: Pragmatic randomized trial. J Gastroenterol Hepatol 2019;34(12):2077-85. https://doi.org/10.1111/jgh.14737
  29. Cheong PK, Ford AC, Cheung CKY, Ching JYL, Chan Y, Sung JJY, et al. Low-dose imipramine for refractory functional dyspepsia: a randomized, double-blind, placebo-controlled trial. Lancet Gastroenterol Hepatol 2018;3(12):837-44. https://doi.org/10.1016/S2468-1253(18)30303-0