Clinical and Experimental Reproductive Medicine

The Korean Society for Reproductive Medicine (대한생식의학회)
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Coenzyme Q10, oxidative stress markers, and sperm DNA damage in men with idiopathic oligoasthenoteratospermia

  • Alahmar, Ahmed T (Department of Medical Physiology, College of Medicine, University of Babylon) ;
  • Sengupta, Pallav (Department of Physiology, MAHSA University) ;
  • Dutta, Sulagna (Department of Physiology, MAHSA University) ;
  • Calogero, Aldo E. (Division of Andrology and Endocrinology, University Teaching Hospital "Policlinico-Vittorio Emanuele", University of Catania)
  • Received : 2020.09.13
  • Accepted : 2020.12.11
  • Published : 2021.06.30
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Abstract

Objective: Oxidative stress (OS) plays a key role in the etiology of unexplained male infertility. Coenzyme Q10 (CoQ10) is a potent antioxidant that may improve semen quality and OS in infertile men with idiopathic oligoasthenoteratospermia (OAT), but the underlying mechanism is unknown. Therefore, the present study was undertaken to investigate the effect of CoQ10 on OS markers and sperm DNA damage in infertile patients with idiopathic OAT. Methods: This prospective controlled study included 50 patients with idiopathic OAT and 50 fertile men who served as controls. All patients underwent a comprehensive medical assessment. Patients and controls received 200 mg of oral CoQ10 once daily for 3 months. Semen and blood were collected and analyzed for sperm parameters, seminal CoQ10 levels, reactive oxygen species (ROS) levels, total antioxidant capacity, catalase, sperm DNA fragmentation (SDF), and serum hormonal profile. Results: The administration of CoQ10 to patients with idiopathic OAT significantly improved sperm quality and seminal antioxidant status and significantly reduced total ROS and SDF levels compared to pretreatment values. Conclusion: CoQ10, at a dose of 200 mg/day for 3 months, may be a potential therapy for infertile patients with idiopathic OAT, as it improved sperm parameters and reduced OS and SDF in these patients.

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References

  1. Alahmar AT, Calogero AE, Sengupta P, Dutta S. Coenzyme Q10 improves sperm parameters, oxidative stress markers and sperm DNA fragmentation in infertile patients with idiopathic oligoasthenozoospermia. World J Mens Health 2021;39:346-51. https://doi.org/10.5534/wjmh.190145
  2. Suliga E, Gluszek S. The relationship between diet, energy balance and fertility in men. Int J Vitam Nutr Res 2020;90:514-26. https://doi.org/10.1024/0300-9831/a000577
  3. Agarwal A, Mulgund A, Hamada A, Chyatte MR. A unique view on male infertility around the globe. Reprod Biol Endocrinol 2015;13:37. https://doi.org/10.1186/s12958-015-0032-1
  4. Ilacqua A, Izzo G, Emerenziani GP, Baldari C, Aversa A. Lifestyle and fertility: the influence of stress and quality of life on male fertility. Reprod Biol Endocrinol 2018;16:115. https://doi.org/10.1186/s12958-018-0436-9
  5. Esteves SC. Clinical relevance of routine semen analysis and controversies surrounding the 2010: World Health Organization criteria for semen examination. Int Braz J Urol 2014;40:443-53. https://doi.org/10.1590/S1677-5538.IBJU.2014.04.02
  6. Alahmar AT. Role of oxidative stress in male infertility: an updated review. J Hum Reprod Sci 2019;12:4-18. https://doi.org/10.4103/jhrs.JHRS_150_18
  7. Tadros NN, Sabanegh ES. Empiric medical therapy with hormonal agents for idiopathic male infertility. Indian J Urol 2017;33:194-8. https://doi.org/10.4103/iju.IJU_368_16
  8. Darbandi M, Darbandi S, Agarwal A, Sengupta P, Durairajanayagam D, Henkel R, et al. Reactive oxygen species and male reproductive hormones. Reprod Biol Endocrinol 2018;16:87. https://doi.org/10.1186/s12958-018-0406-2
  9. Tirabassi G, Vignini A, Tiano L, Buldreghini E, Bruge F, Silvestri S, et al. Protective effects of coenzyme Q10 and aspartic acid on oxidative stress and DNA damage in subjects affected by idiopathic asthenozoospermia. Endocrine 2015;49:549-52. https://doi.org/10.1007/s12020-014-0432-6
  10. Bentov Y, Hannam T, Jurisicova A, Esfandiari N, Casper RF. Coenzyme Q10 supplementation and oocyte aneuploidy in women undergoing IVF-ICSI treatment. Clin Med Insights Reprod Health 2014;8:31-6.
  11. Alahmar AT. The effects of oral antioxidants on the semen of men with idiopathic oligoasthenoteratozoospermia. Clin Exp Reprod Med 2018;45:57-66. https://doi.org/10.5653/cerm.2018.45.2.57
  12. Dutta S, Henkel R, Sengupta P, Agarwal A. Physiological role of ROS in sperm function. In: Parekattil Sijo J, Esteves SC, Agarwal A, editors. Male infertility: contemporary clinical approaches, andrology, ART and antioxidants. Cham: Springer; 2020. p. 337-45.
  13. Dutta S, Majzoub A, Agarwal A. Oxidative stress and sperm function: a systematic review on evaluation and management. Arab J Urol 2019;17:87-97. https://doi.org/10.1080/2090598X.2019.1599624
  14. Wright C, Milne S, Leeson H. Sperm DNA damage caused by oxidative stress: modifiable clinical, lifestyle and nutritional factors in male infertility. Reprod Biomed Online 2014;28:684-703. https://doi.org/10.1016/j.rbmo.2014.02.004
  15. Majzoub A, Agarwal A. Systematic review of antioxidant types and doses in male infertility: benefits on semen parameters, advanced sperm function, assisted reproduction and live-birth rate. Arab J Urol 2018;16:113-24. https://doi.org/10.1016/j.aju.2017.11.013
  16. Alahmar AT, Sengupta P. Impact of coenzyme Q10 and selenium on seminal fluid parameters and antioxidant status in men with idiopathic infertility. Biol Trace Elem Res 2021;199:1246-52. https://doi.org/10.1007/s12011-020-02251-3
  17. Panner Selvam MK, Agarwal A. A systematic review on sperm DNA fragmentation in male factor infertility: laboratory assessment. Arab J Urol 2018;16:65-76. https://doi.org/10.1016/j.aju.2017.12.001
  18. Vishvkarma R, Alahmar AT, Gupta G, Rajender S. Coenzyme Q10 effect on semen parameters: Profound or meagre? Andrologia 2020;52:e13570.
  19. Imamovic Kumalic S, Pinter B. Review of clinical trials on effects of oral antioxidants on basic semen and other parameters in idiopathic oligoasthenoteratozoospermia. Biomed Res Int 2014;2014:426951. https://doi.org/10.1155/2014/426951
  20. Alahmar AT. The impact of two doses of coenzyme Q10 on semen parameters and antioxidant status in men with idiopathic oligoasthenoteratozoospermia. Clin Exp Reprod Med 2019;46:112-8. https://doi.org/10.5653/cerm.2019.00136
  21. Balercia G, Buldreghini E, Vignini A, Tiano L, Paggi F, Amoroso S, et al. Coenzyme Q10 treatment in infertile men with idiopathic asthenozoospermia: a placebo-controlled, double-blind randomized trial. Fertil Steril 2009;91:1785-92. https://doi.org/10.1016/j.fertnstert.2008.02.119
  22. World Health Organization. WHO laboratory manual for the examination and processing of human semen. 5th ed. Geneva: WHO Press; 2010.
  23. Li K, Shi Y, Chen S, Li W, Shang X, Huang Y. Determination of coenzyme Q10 in human seminal plasma by high-performance liquid chromatography and its clinical application. Biomed Chromatogr 2006;20:1082-6. https://doi.org/10.1002/bmc.645
  24. Venkatesh S, Shamsi MB, Dudeja S, Kumar R, Dada R. Reactive oxygen species measurement in neat and washed semen: comparative analysis and its significance in male infertility assessment. Arch Gynecol Obstet 2011;283:121-6.
  25. Zaazaa A, Adel A, Fahmy I, Elkhiat Y, Awaad AA, Mostafa T. Effect of varicocelectomy and/or mast cells stabilizer on sperm DNA fragmentation in infertile patients with varicocele. Andrology 2018;6:146-50. https://doi.org/10.1111/andr.12445
  26. Lafuente R, Gonzalez-Comadran M, Sola I, Lopez G, Brassesco M, Carreras R, et al. Coenzyme Q10 and male infertility: a meta-analysis. J Assist Reprod Genet 2013;30:1147-56. https://doi.org/10.1007/s10815-013-0047-5
  27. Minamiyama Y, Ichikawa H, Masui T, Kobayashi K, Takemura S, Oka MO, et al. Oral administration of reduced coenzyme Q10 ameliorates the endocrine-disrupting chemical-induced sperm toxicity in rats. Free Radic Biol Med 2016;100:S105-6.
  28. Beharry KD, Cai CL, Henry MM, Chowdhury S, Valencia GB, Aranda JV. Co-Enzyme Q10 and n-3 polyunsaturated fatty acid supplementation reverse intermittent hypoxia-induced growth restriction and improved antioxidant profiles in neonatal rats. Antioxidants (Basel) 2017;6:103. https://doi.org/10.3390/antiox6040103
  29. Leaver RB. Male infertility: an overview of causes and treatment options. Br J Nurs 2016;25:S35-40. https://doi.org/10.12968/bjon.2016.25.18.S35
  30. Majzoub A, Agarwal A. Antioxidant therapy in idiopathic oligoasthenoteratozoospermia. Indian J Urol 2017;33:207-14. https://doi.org/10.4103/iju.IJU_15_17
  31. Safarinejad MR. The effect of coenzyme Q11 supplementation on partner pregnancy rate in infertile men with idiopathic oligoasthenoteratozoospermia: an open-label prospective study. Int Urol Nephrol 2012;44:689-700. https://doi.org/10.1007/s11255-011-0081-0
  32. Safarinejad MR, Safarinejad S, Shafiei N, Safarinejad S. Effects of the reduced form of coenzyme Q10 (ubiquinol) on semen parameters in men with idiopathic infertility: a double-blind, placebo controlled, randomized study. J Urol 2012;188:526-31. https://doi.org/10.1016/j.juro.2012.03.131
  33. Nadjarzadeh A, Shidfar F, Amirjannati N, Vafa MR, Motevalian SA, Gohari MR, et al. Effect of Coenzyme Q10 supplementation on antioxidant enzymes activity and oxidative stress of seminal plasma: a double-blind randomised clinical trial. Andrologia 2014;46:177-83. https://doi.org/10.1111/and.12062
  34. Al-Mosawi AM. The role of different antioxidant agents in human infertility and assisted reproductive techniques. J Nat Sci Res 2016;6:57-64.
  35. Tiseo BC, Gaskins AJ, Hauser R, Chavarro JE, Tanrikut C; EARTH Study Team. Coenzyme Q10 intake from food and semen parameters in a subfertile population. Urology 2017;102:100-5. https://doi.org/10.1016/j.urology.2016.11.022
  36. Huang C, Cao X, Pang D, Li C, Luo Q, Zou Y, et al. Is male infertility associated with increased oxidative stress in seminal plasma? A-meta analysis. Oncotarget 2018;9:24494-513. https://doi.org/10.18632/oncotarget.25075
  37. Ko EY, Sabanegh ES. The role of nutraceuticals in male fertility. Urol Clin North Am 2014;41:181-93. https://doi.org/10.1016/j.ucl.2013.08.003

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