Acknowledgement
The authors would like to thank Dr. Suphanut Danphichitsuk, a sixth-year medical student, who helped to extract the data from electronic medical records, and Assist. Prof. Dr. Chulaluk Komoltri, a clinical epidemiologist at the Faculty of Medicine Siriraj Hospital, Mahidol University, for assistance with the statistical analysis.
References
- Zhang H, Wang S, Zhang S, Wang T, Deng X. Increasing trend of prevalence of infertility in Beijing. Chin Med J (Engl) 2014;127:691-5. https://doi.org/10.3760/cma.j.issn.0366-6999.20132698
- Dick ML, Bain CJ, Purdie DM, Siskind V, Molloy D, Green AC. Self-reported difficulty in conceiving as a measure of infertility. Hum Reprod 2003;18:2711-7. https://doi.org/10.1093/humrep/deg504
- Tuntiseranee P, Olsen J, Chongsuvivatwong V, Limbutara S. Fecundity in Thai and European regions: results based on waiting time to pregnancy. Hum Reprod 1998;13:471-7. https://doi.org/10.1093/humrep/13.2.471
- Siristatidis C, Komitopoulou MA, Makris A, Sialakouma A, Botzaki M, Mastorakos G, et al. Morphokinetic parameters of early embryo development via time lapse monitoring and their effect on embryo selection and ICSI outcomes: a prospective cohort study. J Assist Reprod Genet 2015;32:563-70. https://doi.org/10.1007/s10815-015-0436-z
- Kuivasaari P, Hippelainen M, Anttila M, Heinonen S. Effect of endometriosis on IVF/ICSI outcome: stage III/IV endometriosis worsens cumulative pregnancy and live-born rates. Hum Reprod 2005;20:3130-5. https://doi.org/10.1093/humrep/dei176
- Diedrich K, Felberbaum R, Kupker W, al-Hasani S. New approaches to male infertility: IVF and microinjection. Int J Androl 1995;18 Suppl 2:78-80.
- Martin JR, Bromer JG, Sakkas D, Patrizio P. Live babies born per oocyte retrieved in a subpopulation of oocyte donors with repetitive reproductive success. Fertil Steril 2010;94:2064-8. https://doi.org/10.1016/j.fertnstert.2010.02.004
- Nel-Themaat L, Nagy ZP. A review of the promises and pitfalls of oocyte and embryo metabolomics. Placenta 2011;32 Suppl 3:S257-63. https://doi.org/10.1016/j.placenta.2011.05.011
- Cummins JM, Breen TM, Harrison KL, Shaw JM, Wilson LM, Hennessey JF. A formula for scoring human embryo growth rates in in vitro fertilization: its value in predicting pregnancy and in comparison with visual estimates of embryo quality. J In Vitro Fert Embryo Transf 1986;3:284-95. https://doi.org/10.1007/BF01133388
- Alpha Scientists in Reproductive Medicine and ESHRE Special Interest Group of Embryology. The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting. Hum Reprod 2011;26:1270-83. https://doi.org/10.1093/humrep/der037
- Fujiwara M, Takahashi K, Izuno M, Duan YR, Kazono M, Kimura F, et al. Effect of micro-environment maintenance on embryo culture after in-vitro fertilization: comparison of top-load mini incubator and conventional front-load incubator. J Assist Reprod Genet 2007;24:5-9. https://doi.org/10.1007/s10815-006-9088-3
- Rubio I, Kuhlmann R, Agerholm I, Kirk J, Herrero J, Escriba MJ, et al. Limited implantation success of direct-cleaved human zygotes: a time-lapse study. Fertil Steril 2012;98:1458-63. https://doi.org/10.1016/j.fertnstert.2012.07.1135
- Liu Y, Chapple V, Roberts P, Matson P. Prevalence, consequence, and significance of reverse cleavage by human embryos viewed with the use of the Embryoscope time-lapse video system. Fertil Steril 2014;102:1295-300.e2. https://doi.org/10.1016/j.fertnstert.2014.07.1235
- Cruz M, Gadea B, Garrido N, Pedersen KS, Martinez M, Perez-Cano I, et al. Embryo quality, blastocyst and ongoing pregnancy rates in oocyte donation patients whose embryos were monitored by time-lapse imaging. J Assist Reprod Genet 2011;28:569-73. https://doi.org/10.1007/s10815-011-9549-1
- Herrero J, Meseguer M. Selection of high potential embryos using time-lapse imaging: the era of morphokinetics. Fertil Steril 2013;99:1030-4. https://doi.org/10.1016/j.fertnstert.2013.01.089
- Desai N, Ploskonka S, Goodman LR, Austin C, Goldberg J, Falcone T. Analysis of embryo morphokinetics, multinucleation and cleavage anomalies using continuous time-lapse monitoring in blastocyst transfer cycles. Reprod Biol Endocrinol 2014;12:54. https://doi.org/10.1186/1477-7827-12-54
- Goodman LR, Goldberg J, Falcone T, Austin C, Desai N. Does the addition of time-lapse morphokinetics in the selection of embryos for transfer improve pregnancy rates? A randomized controlled trial. Fertil Steril 2016;105:275-85.e10. https://doi.org/10.1016/j.fertnstert.2015.10.013
- Sundvall L, Ingerslev HJ, Breth Knudsen U, Kirkegaard K. Inter- and intra-observer variability of time-lapse annotations. Hum Reprod 2013;28:3215-21. https://doi.org/10.1093/humrep/det366
- Meseguer M, Herrero J, Tejera A, Hilligsoe KM, Ramsing NB, Remohi J. The use of morphokinetics as a predictor of embryo implantation. Hum Reprod 2011;26:2658-71. https://doi.org/10.1093/humrep/der256
- Zhang JQ, Li XL, Peng Y, Guo X, Heng BC, Tong GQ. Reduction in exposure of human embryos outside the incubator enhances embryo quality and blastulation rate. Reprod Biomed Online 2010;20:510-5. https://doi.org/10.1016/j.rbmo.2009.12.027
- Castello D, Motato Y, Basile N, Remohi J, Espejo-Catena M, Meseguer M. How much have we learned from time-lapse in clinical IVF? Mol Hum Reprod 2016;22:719-27. https://doi.org/10.1093/molehr/gaw056
- Ebner T, Oppelt P, Radler E, Allerstorfer C, Habelsberger A, Mayer RB, et al. Morphokinetics of vitrified and warmed blastocysts predicts implantation potential. J Assist Reprod Genet 2017;34:239-44. https://doi.org/10.1007/s10815-016-0855-5
- Meseguer M, Rubio I, Cruz M, Basile N, Marcos J, Requena A. Embryo incubation and selection in a time-lapse monitoring system improves pregnancy outcome compared with a standard incubator: a retrospective cohort study. Fertil Steril 2012;98:1481-9.e10. https://doi.org/10.1016/j.fertnstert.2012.08.016
- Pribenszky C, Nilselid AM, Montag M. Time-lapse culture with morphokinetic embryo selection improves pregnancy and live birth chances and reduces early pregnancy loss: a meta-analysis. Reprod Biomed Online 2017;35:511-20. https://doi.org/10.1016/j.rbmo.2017.06.022
- Kirkegaard K, Kesmodel US, Hindkjaer JJ, Ingerslev HJ. Time-lapse parameters as predictors of blastocyst development and pregnancy outcome in embryos from good prognosis patients: a prospective cohort study. Hum Reprod 2013;28:2643-51. https://doi.org/10.1093/humrep/det300
- Kirkegaard K, Hindkjaer JJ, Grondahl ML, Kesmodel US, Ingerslev HJ. A randomized clinical trial comparing embryo culture in a conventional incubator with a time-lapse incubator. J Assist Reprod Genet 2012;29:565-72. https://doi.org/10.1007/s10815-012-9750-x
- Racowsky C, Kovacs P, Martins WP. A critical appraisal of time-lapse imaging for embryo selection: where are we and where do we need to go? J Assist Reprod Genet 2015;32:1025-30. https://doi.org/10.1007/s10815-015-0510-6
- Montag M. Morphokinetics and embryo aneuploidy: has time come or not yet? Reprod Biomed Online 2013;26:528-30. https://doi.org/10.1016/j.rbmo.2013.03.011
- Ottolini C, Rienzi L, Capalbo A. A cautionary note against embryo aneuploidy risk assessment using time-lapse imaging. Reprod Biomed Online 2014;28:273-5. https://doi.org/10.1016/j.rbmo.2013.10.015
- Lemmen JG, Agerholm I, Ziebe S. Kinetic markers of human embryo quality using time-lapse recordings of IVF/ICSI-fertilized oocytes. Reprod Biomed Online 2008;17:385-91. https://doi.org/10.1016/S1472-6483(10)60222-2
- Sciorio R, Thong JK, Pickering SJ. Comparison of the development of human embryos cultured in either an EmbryoScope or benchtop incubator. J Assist Reprod Genet 2018;35:515-22. https://doi.org/10.1007/s10815-017-1100-6
- Scheffer JB, Scheffer BB, de Carvalho RF, Rodrigues J, Grynberg M, Mendez Lozano DH. Age as a predictor of embryo quality regardless of the quantitative ovarian response. Int J Fertil Steril 2017;11:40-6.
- Del Carmen Nogales M, Bronet F, Basile N, Martinez EM, Linan A, Rodrigo L, et al. Type of chromosome abnormality affects embryo morphology dynamics. Fertil Steril 2017;107:229-35.e2. https://doi.org/10.1016/j.fertnstert.2016.09.019
- Athayde Wirka K, Chen AA, Conaghan J, Ivani K, Gvakharia M, Behr B, et al. Atypical embryo phenotypes identified by time-lapse microscopy: high prevalence and association with embryo development. Fertil Steril 2014;101:1637-48.e1-5. https://doi.org/10.1016/j.fertnstert.2014.02.050
- Zhan Q, Ye Z, Clarke R, Rosenwaks Z, Zaninovic N. Direct unequal cleavages: embryo developmental competence, genetic constitution and clinical outcome. PLoS One 2016;11:e0166398. https://doi.org/10.1371/journal.pone.0166398
- Kirkegaard K, Ahlstrom A, Ingerslev HJ, Hardarson T. Choosing the best embryo by time lapse versus standard morphology. Fertil Steril 2015;103:323-32. https://doi.org/10.1016/j.fertnstert.2014.11.003
- Rubio I, Galan A, Larreategui Z, Ayerdi F, Bellver J, Herrero J, et al. Clinical validation of embryo culture and selection by morphokinetic analysis: a randomized, controlled trial of the EmbryoScope. Fertil Steril 2014;102:1287-94.e5. https://doi.org/10.1016/j.fertnstert.2014.07.738
- Wong CC, Loewke KE, Bossert NL, Behr B, De Jonge CJ, Baer TM, et al. Non-invasive imaging of human embryos before embryonic genome activation predicts development to the blastocyst stage. Nat Biotechnol 2010;28:1115-21. https://doi.org/10.1038/nbt.1686
- Conaghan J, Chen AA, Willman SP, Ivani K, Chenette PE, Boostanfar R, et al. Improving embryo selection using a computer-automated time-lapse image analysis test plus day 3 morphology: results from a prospective multicenter trial. Fertil Steril 2013;100:412-9.e5. https://doi.org/10.1016/j.fertnstert.2013.04.021
- Polanski LT, Coelho Neto MA, Nastri CO, Navarro PA, Ferriani RA, Raine-Fenning N, et al. Time-lapse embryo imaging for improving reproductive outcomes: systematic review and meta-analysis. Ultrasound Obstet Gynecol 2014;44:394-401. https://doi.org/10.1002/uog.13428
- Armstrong S, Vail A, Mastenbroek S, Jordan V, Farquhar C. Timelapse in the IVF-lab: how should we assess potential benefit? Hum Reprod 2015;30:3-8. https://doi.org/10.1093/humrep/deu250
- Armstrong S, Arroll N, Cree LM, Jordan V, Farquhar C. Time-lapse systems for embryo incubation and assessment in assisted reproduction. Cochrane Database Syst Rev 2015;(2):CD011320.
- Scott RT Jr, Upham KM, Forman EJ, Hong KH, Scott KL, Taylor D, et al. Blastocyst biopsy with comprehensive chromosome screening and fresh embryo transfer significantly increases in vitro fertilization implantation and delivery rates: a randomized controlled trial. Fertil Steril 2013;100:697-703. https://doi.org/10.1016/j.fertnstert.2013.04.035
- Forman EJ, Hong KH, Ferry KM, Tao X, Taylor D, Levy B, et al. In vitro fertilization with single euploid blastocyst transfer: a randomized controlled trial. Fertil Steril 2013;100:100-7.e1. https://doi.org/10.1016/j.fertnstert.2013.02.056
- Yang Z, Liu J, Collins GS, Salem SA, Liu X, Lyle SS, et al. Selection of single blastocysts for fresh transfer via standard morphology assessment alone and with array CGH for good prognosis IVF patients: results from a randomized pilot study. Mol Cytogenet 2012;5:24. https://doi.org/10.1186/1755-8166-5-24