Journal of Powder Materials (한국분말재료학회지)

The Korean Powder Metallurgy & Materials Institute (한국분말재료학회 (*구 분말야금학회))
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Fabrication and Characterization of Bangpungtongseong-San Extract-loaded Particles for Tablet Dosage Form

생약 추출물 함유 정제 제조를 위한 이산화규소 함유 분말의 제조 및 평가

  • Park, Jinwoo (Department of Pharmaceutical Engineering, Dankook University) ;
  • Jin, Sung Giu (Department of Pharmaceutical Engineering, Dankook University)
  • 박진우 (단국대학교 제약공학과) ;
  • 진성규 (단국대학교 제약공학과)
  • Received : 2021.06.11
  • Accepted : 2021.06.26
  • Published : 2021.06.28
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Abstract

The purpose of this study is to optimize the powder formulation and manufacturing conditions for the solidification of an extract of the herb Bangpungtongseong-san (BPTS). To develop BPTS-loaded particles for the tablet dosage form, various BPTS-loaded particles composed of BPTS, dextrin, microcrystalline cellulose (MCC), silicon dioxide, ethanol, and water are prepared using spray-drying and high shear granulation (high-speed mixing). Their physical properties are evaluated using scanning electron microscopy and measurements of the angle of repose, Hausner ratio, Carr's index, hardness, and disintegration time. The optimal BPTS-loaded particles exhibit improved flowability and compressibility. In particular, the BPTS-loaded particles containing silicon dioxide show significantly improved flowability and compressibility (the angle of repose, Hausner ratio, and Carr's index are 35.27 ± 0.58°, 1.18 ± 0.06, and 15.67 ± 1.68%, respectively), hardness (18.97 ± 1.00 KP), and disintegration time (17.60 ± 1.50 min) compared to those without silicon dioxide. Therefore, this study suggests that particles prepared by high-speed mixing can be used to greatly improve the flowability and compressibility of BPTS using MCC and silicon dioxide.

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References

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