Korean Journal of Radiology

The Korean Society of Radiology (대한영상의학회)
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Percutaneous Thrombin Injection Based on Computational Fluid Dynamics of Femoral Artery Pseudoaneurysms

  • Hyoung-Ho Kim (School of Mechanical Engineering, Gyeongsang National University) ;
  • Kyung-Wuk Kim (Department of Mechanical Engineering, Soongsil University) ;
  • Changje Lee (Center for Bionics, Korea Institute of Science and Technology) ;
  • Young Ho Choi (Department of Radiology, Seoul National University Boramae Hospital) ;
  • Min Uk Kim (Department of Radiology, Seoul National University Boramae Hospital) ;
  • Yasutaka Baba (Department of Radiology, Hiroshima University Hospital)
  • Received : 2020.05.14
  • Accepted : 2021.04.27
  • Published : 2021.11.01
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Abstract

Objective: To analyze the computational fluid dynamics (CFD) of femoral artery pseudoaneurysm (FAP), identify a suitable location and timing for percutaneous thrombin injection (PTI) based on this analysis, and report our clinical experience with the procedure. Materials and Methods: CFD can be used to analyze the hemodynamics of the human body. An analysis using CFD recommended that the suitable location of the needle tip for PTI is at the center of the aneurysm sac and the optimal timing for starting PTI is during the early inflow phase of blood into the sac. Since 2011, seven patients (three male and four female; median age, 60 years [range, 43-75 years]) with FAP were treated with PTI based on the devised suitable location and time. Prior to the procedure, color Doppler ultrasonography was performed to determine the location and timing of the thrombin injection. Results: The technical success rate of the PTI was 100%. The amount of thrombin used for the procedure ranged from 200 IU to 1000 IU (median, 500 IU). None of the patients experienced any symptoms or signs of embolic complications during the procedure. Follow-up CT images did not reveal any embolism in the lower extremities and showed complete thrombosis of the pseudoaneurysm. Conclusion: Based on our study of CFD, PTI administered centrally in the FAP during early inflow, as seen on color Doppler, can be an effective technique.

Keywords

Acknowledgement

This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (2021R1F1A1051004).

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