Acknowledgement
Yong Eun Chung received faculty research grant of Yonsei University College of Medicine (No. 6-2019-0118).
References
- Kim YY, Kim MJ, Kim EH, Roh YH, An C. Hepatocellular carcinoma versus other hepatic malignancy in cirrhosis: performance of LI-RADS version 2018. Radiology 2019;291:72-80 https://doi.org/10.1148/radiol.2019181995
- Kim YY, Choi JY, Sirlin CB, An C, Kim MJ. Pitfalls and problems to be solved in the diagnostic CT/MRI liver imaging reporting and data system (LI-RADS). Eur Radiol 2019;29:1124-1132 https://doi.org/10.1007/s00330-018-5641-6
- Elsayes KM, Kielar AZ, Chernyak V, Morshid A, Furlan A, Masch WR, et al. LI-RADS: a conceptual and historical review from its beginning to its recent integration into AASLD clinical practice guidance. J Hepatocell Carcinoma 2019;6:49-69 https://doi.org/10.2147/JHC.S186239
- Heimbach JK, Kulik LM, Finn RS, Sirlin CB, Abecassis MM, Roberts LR, et al. AASLD guidelines for the treatment of hepatocellular carcinoma. Hepatology 2018;67:358-380 https://doi.org/10.1002/hep.29086
- Efremidis SC, Hytiroglou P. The multistep process of hepatocarcinogenesis in cirrhosis with imaging correlation. Eur Radiol 2002;12:753-764 https://doi.org/10.1007/s00330-001-1142-z
- Choi JW, Lee JM, Kim SJ, Yoon JH, Baek JH, Han JK, et al. Hepatocellular carcinoma: imaging patterns on gadoxetic acid-enhanced MR images and their value as an imaging biomarker. Radiology 2013;267:776-786 https://doi.org/10.1148/radiol.13120775
- Choi JY, Lee JM, Sirlin CB. CT and MR imaging diagnosis and staging of hepatocellular carcinoma: part II. Extracellular agents, hepatobiliary agents, and ancillary imaging features. Radiology 2014;273:30-50 https://doi.org/10.1148/radiol.14132362
- Matsui O, Kobayashi S, Sanada J, Kouda W, Ryu Y, Kozaka K, et al. Hepatocelluar nodules in liver cirrhosis: hemodynamic evaluation (angiography-assisted CT) with special reference to multi-step hepatocarcinogenesis. Abdom Imaging 2011;36:264-272 https://doi.org/10.1007/s00261-011-9685-1
- Forner A, Vilana R, Ayuso C, Bianchi L, Sole M, Ayuso JR, et al. Diagnosis of hepatic nodules 20 mm or smaller in cirrhosis: prospective validation of the noninvasive diagnostic criteria for hepatocellular carcinoma. Hepatology 2008;47:97-104
- Kim TK, Lee KH, Jang HJ, Haider MA, Jacks LM, Menezes RJ, et al. Analysis of gadobenate dimeglumine-enhanced MR findings for characterizing small (1-2-cm) hepatic nodules in patients at high risk for hepatocellular carcinoma. Radiology 2011;259:730-738 https://doi.org/10.1148/radiol.11101549
- Ishigami K, Yoshimitsu K, Nishihara Y, Irie H, Asayama Y, Tajima T, et al. Hepatocellular carcinoma with a pseudocapsule on gadolinium-enhanced MR images: correlation with histopathologic findings. Radiology 2009;250:435-443 https://doi.org/10.1148/radiol.2501071702
- Lim JH, Choi D, Park CK, Lee WJ, Lim HK. Encapsulated hepatocellular carcinoma: CT-pathologic correlations. Eur Radiol 2006;16:2326-2333 https://doi.org/10.1007/s00330-006-0203-8
- Korean Liver Cancer Association, National Cancer Center. 2018 Korean Liver Cancer Association-National Cancer Center Korea Practice Guidelines for the management of hepatocellular carcinoma. Gut Liver 2019;13:227-299 https://doi.org/10.5009/gnl19024
- Omata M, Cheng AL, Kokudo N, Kudo M, Lee JM, Jia J, et al. Asia-Pacific clinical practice guidelines on the management of hepatocellular carcinoma: a 2017 update. Hepatol Int 2017;11:317-370 https://doi.org/10.1007/s12072-017-9799-9
- Marrero JA, Kulik LM, Sirlin CB, Zhu AX, Finn RS, Abecassis MM, et al. Diagnosis, staging, and management of hepatocellular carcinoma: 2018 practice guidance by the American Association for the Study of Liver Diseases. Hepatology 2018;68:723-750 https://doi.org/10.1002/hep.29913
- European Association for the Study of the Liver. EASL clinical practice guidelines: management of hepatocellular carcinoma. J Hepatol 2018;69:182-236 https://doi.org/10.1016/j.jhep.2018.03.019
- Rosenkrantz AB, Campbell N, Wehrli N, Triolo MJ, Kim S. New OPTN/UNOS classification system for nodules in cirrhotic livers detected with MR imaging: effect on hepatocellular carcinoma detection and transplantation allocation. Radiology 2015;274:426-433 https://doi.org/10.1148/radiol.14140069
- Kim JK, Kim HD, Jun MJ, Yun SC, Shim JH, Lee HC, et al. Tumor volume doubling time as a dynamic prognostic marker for patients with hepatocellular carcinoma. Dig Dis Sci 2017;62:2923-2931 https://doi.org/10.1007/s10620-017-4708-6
- An C, Choi YA, Choi D, Paik YH, Ahn SH, Kim MJ, et al. Growth rate of early-stage hepatocellular carcinoma in patients with chronic liver disease. Clin Mol Hepatol 2015;21:279-286 https://doi.org/10.3350/cmh.2015.21.3.279
- Shingaki N, Tamai H, Mori Y, Moribata K, Enomoto S, Deguchi H, et al. Serological and histological indices of hepatocellular carcinoma and tumor volume doubling time. Mol Clin Oncol 2013;1:977-981 https://doi.org/10.3892/mco.2013.186
- De Rose AM, Cucchetti A, Clemente G, Ardito F, Giovannini I, Ercolani G, et al. Prognostic significance of tumor doubling time in mass-forming type cholangiocarcinoma. J Gastrointest Surg 2013;17:739-747 https://doi.org/10.1007/s11605-012-2129-6
- Chernyak V, Kobi M, Flusberg M, Fruitman KC, Sirlin CB. Effect of threshold growth as a major feature on LI-RADS categorization. Abdom Radiol (NY) 2017;42:2089-2100 https://doi.org/10.1007/s00261-017-1105-8
- Park JH, Chung YE, Seo N, Choi JY, Park MS, Kim MJ. Gadoxetic acid-enhanced MRI of hepatocellular carcinoma: diagnostic performance of category-adjusted LR-5 using modified criteria. PLoS One 2020;15:e0242344
- Lee S, Kim SS, Chang DR, Kim H, Kim MJ. Comparison of LI-RADS 2018 and KLCA-NCC 2018 for noninvasive diagnosis of hepatocellular carcinoma using magnetic resonance imaging. Clin Mol Hepatol 2020;26:340-351 https://doi.org/10.3350/cmh.2020.0004
- American College of Radiology. CT/MRI LI-RADS® v2018. Acr.org Web site. https://www.acr.org/Clinical-Resources/Reporting-and-Data-Systems/LI-RADS/CT-MRI-LI-RADS-v2018. Accessed November 6, 2020
- Edmondson HA, Steiner PE. Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. Cancer 1954;7:462-503 https://doi.org/10.1002/1097-0142(195405)7:3<462::AID-CNCR2820070308>3.0.CO;2-E
- Lee S, Kim MJ, Kim SS, Shin H, Kim DY, Choi JY, et al. Retrospective comparison of EASL 2018 and LI-RADS 2018 for the noninvasive diagnosis of hepatocellular carcinoma using magnetic resonance imaging. Hepatol Int 2020;14:70-79 https://doi.org/10.1007/s12072-019-10002-3
- Batts KP, Ludwig J. Chronic hepatitis. An update on terminology and reporting. Am J Surg Pathol 1995;19:1409-1417 https://doi.org/10.1097/00000478-199512000-00007
- Cerny M, Chernyak V, Olivie D, Billiard JS, Murphy-Lavallee J, Kielar AZ, et al. LI-RADS version 2018 ancillary features at MRI. Radiographics 2018;38:1973-2001 https://doi.org/10.1148/rg.2018180052
- Cho ES, Choi JY. MRI features of hepatocellular carcinoma related to biologic behavior. Korean J Radiol 2015;16:449-464 https://doi.org/10.3348/kjr.2015.16.3.449
- Cucchetti A, Vivarelli M, Piscaglia F, Nardo B, Montalti R, Grazi GL, et al. Tumor doubling time predicts recurrence after surgery and describes the histological pattern of hepatocellular carcinoma on cirrhosis. J Hepatol 2005;43:310-316 https://doi.org/10.1016/j.jhep.2005.03.014
- Ebara M, Hatano R, Fukuda H, Yoshikawa M, Sugiura N, Saisho H. Natural course of small hepatocellular carcinoma with underlying cirrhosis. A study of 30 patients. Hepatogastroenterology 1998;45 Suppl 3:1214-1220
- An C, Rakhmonova G, Choi JY, Kim MJ. Liver imaging reporting and data system (LI-RADS) version 2014: understanding and application of the diagnostic algorithm. Clin Mol Hepatol 2016;22:296-307 https://doi.org/10.3350/cmh.2016.0028
- Cerny M, Bergeron C, Billiard JS, Murphy-Lavallee J, Olivie D, Berube J, et al. LI-RADS for MR imaging diagnosis of hepatocellular carcinoma: performance of major and ancillary features. Radiology 2018;288:118-128 https://doi.org/10.1148/radiol.2018171678
- Borzio M, Fargion S, Borzio F, Fracanzani AL, Croce AM, Stroffolini T, et al. Impact of large regenerative, low grade and high grade dysplastic nodules in hepatocellular carcinoma development. J Hepatol 2003;39:208-214 https://doi.org/10.1016/S0168-8278(03)00190-9