Korean Journal of Radiology

The Korean Society of Radiology (대한영상의학회)
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Characterization of Brain Microstructural Abnormalities in High Myopia Patients: A Preliminary Diffusion Kurtosis Imaging Study

  • Huihui Wang (Department of Radiology, Beijing Friendship Hospital, Capital Medical University) ;
  • Hongwei Wen (Key Laboratory of Cognition and Personality (Ministry of Education), School of Psychology, Southwest University) ;
  • Jing Li (Department of Radiology, Beijing Friendship Hospital, Capital Medical University) ;
  • Qian Chen (Department of Radiology, Beijing Friendship Hospital, Capital Medical University) ;
  • Shanshan Li (Department of Radiology, Beijing Friendship Hospital, Capital Medical University) ;
  • Yanling Wang (Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University) ;
  • Zhenchang Wang (Department of Radiology, Beijing Friendship Hospital, Capital Medical University)
  • Received : 2020.02.27
  • Accepted : 2020.07.17
  • Published : 2021.07.01
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Abstract

Objective: To evaluate microstructural damage in high myopia (HM) patients using 3T diffusion kurtosis imaging (DKI). Materials and Methods: This prospective study included 30 HM patients and 33 age- and sex-matched healthy controls (HCs) with DKI. Kurtosis parameters including kurtosis fractional anisotropy (FA), mean kurtosis (MK), axial kurtosis (AK), and radial kurtosis (RK) as well as diffusion metrics including FA, mean diffusivity, axial diffusivity (AD), and radial diffusivity derived from DKI were obtained. Group differences in these metrics were compared using tract-based spatial statistics. Partial correlation analysis was used to evaluate correlations between microstructural changes and disease duration. Results: Compared to HCs, HM patients showed significantly reduced AK, RK, MK, and FA and significantly increased AD, predominately in the bilateral corticospinal tract, right inferior longitudinal fasciculus, superior longitudinal fasciculus, inferior fronto-occipital fasciculus, and left thalamus (all p < 0.05, threshold-free cluster enhancement corrected). In addition, DKI-derived kurtosis parameters (AK, RK, and MK) had negative correlations (r = -0.448 to -0.376, all p < 0.05) and diffusion parameter (AD) had positive correlations (r = 0.372 to 0.409, all p < 0.05) with disease duration. Conclusion: HM patients showed microstructural alterations in the brain regions responsible for motor conduction and vision-related functions. DKI is useful for detecting white matter abnormalities in HM patients, which might be helpful for exploring and monitoring the pathogenesis of the disease.

Keywords

Acknowledgement

This work was supported by the National Natural Science Foundation of China (grant number: 61527807, 81800840, 81701644, 61801311, 81871322), Beijing Scholars Program (grant number: [2015] 160), Beijing Municipal Administration of Hospitals (grant number: SML20150101, PX2018001, YYZZ2017A14, YYZZ2017B01), and Fundamental Research Funds for the Central Universities (SWU118065).

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