Korean Journal of Radiology

The Korean Society of Radiology (대한영상의학회)
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Noncontrast Computed Tomography-Based Radiomics Analysis in Discriminating Early Hematoma Expansion after Spontaneous Intracerebral Hemorrhage

  • Zuhua Song (Department of Radiology, The Second Affiliated Hospital of Chongqing Medical University) ;
  • Dajing Guo (Department of Radiology, The Second Affiliated Hospital of Chongqing Medical University) ;
  • Zhuoyue Tang (Department of Radiology, Chongqing General Hospital) ;
  • Huan Liu (GE Healthcare) ;
  • Xin Li (Department of Radiology, The Second Affiliated Hospital of Chongqing Medical University) ;
  • Sha Luo (Department of Radiology, The Second Affiliated Hospital of Chongqing Medical University) ;
  • Xueying Yao (Department of Radiology, The Second Affiliated Hospital of Chongqing Medical University) ;
  • Wenlong Song (Department of Radiology, The Second Affiliated Hospital of Chongqing Medical University) ;
  • Junjie Song (Department of Radiology, The Second Affiliated Hospital of Chongqing Medical University) ;
  • Zhiming Zhou (Department of Radiology, The Second Affiliated Hospital of Chongqing Medical University)
  • Received : 2020.03.10
  • Accepted : 2020.07.02
  • Published : 2021.03.01
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Abstract

Objective: To determine whether noncontrast computed tomography (NCCT) models based on multivariable, radiomics features, and machine learning (ML) algorithms could further improve the discrimination of early hematoma expansion (HE) in patients with spontaneous intracerebral hemorrhage (sICH). Materials and Methods: We retrospectively reviewed 261 patients with sICH who underwent initial NCCT within 6 hours of ictus and follow-up CT within 24 hours after initial NCCT, between April 2011 and March 2019. The clinical characteristics, imaging signs and radiomics features extracted from the initial NCCT images were used to construct models to discriminate early HE. A clinical-radiologic model was constructed using a multivariate logistic regression (LR) analysis. Radiomics models, a radiomics-radiologic model, and a combined model were constructed in the training cohort (n = 182) and independently verified in the validation cohort (n = 79). Receiver operating characteristic analysis and the area under the curve (AUC) were used to evaluate the discriminative power. Results: The AUC of the clinical-radiologic model for discriminating early HE was 0.766. The AUCs of the radiomics model for discriminating early HE built using the LR algorithm in the training and validation cohorts were 0.926 and 0.850, respectively. The AUCs of the radiomics-radiologic model in the training and validation cohorts were 0.946 and 0.867, respectively. The AUCs of the combined model in the training and validation cohorts were 0.960 and 0.867, respectively. Conclusion: NCCT models based on multivariable, radiomics features and ML algorithm could improve the discrimination of early HE. The combined model was the best recommended model to identify sICH patients at risk of early HE.

Keywords

Acknowledgement

This study was supported by the medical research Key Program of the combination of Chongqing National health commission and Chongqing science and technology bureau, China (no 2019ZDXM010); the Basic and Frontier Research Project of Chongqing, China (no cstc2016jcyjA0294).

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