Parasites, Hosts and Diseases

The Korea Society for Parasitology and Tropical Medicine (대한기생충학·열대의학회)
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Evaluation of the anti-Toxoplasma gondii Activity of Hederagenin in vitro and in vivo

  • Zhang, Run-Hui (Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Yanbian University) ;
  • Jin, Runhao (School of nursing Yanbian University) ;
  • Deng, Hao (Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Yanbian University) ;
  • Shen, Qing-Kun (Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Yanbian University) ;
  • Quan, Zhe-Shan (Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Yanbian University) ;
  • Jin, Chun-Mei (Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Yanbian University)
  • Received : 2020.09.06
  • Accepted : 2021.04.15
  • Published : 2021.06.30
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Abstract

Toxoplasma gondii infection is widespread worldwide, not only posing a serious threat to human food safety and animal husbandry, but also endangering human health. The selectivity index was employed to measure anti-T. gondii activity. Hederagenin (HE) exhibited potent anti-T. gondii activity and low cytotoxicity. For this reason, HE was selected for in vivo experiments. HE showed 64.8%±13.1% inhibition for peritoneal tachyzoites in mice, higher than spiramycin 56.8%±6.0%. Biochemical parameters such as alanine aminotransferase, aspartate aminotransferase, glutathione, and malondialdehyde, illustrated that HE was a good inhibitor of T. gondii in vivo. This compound was also effective in relieving T. gondii-induced liver damage. Collectively, it was demonstrated that HE had potential as an anti-T. gondii agent.

Keywords

Acknowledgement

This work was supported by the National Natural Science Foundation of China (No.81160409, 81960626).

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