International Journal of Oral Biology

The Korean Academy of Oral Biology (대한구강생물학회)
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Expression patterns of Rho-associated protein kinase signaling pathway-related genes in mouse submandibular glands

  • Kim, Ki-Chul (Cellular Reprogramming and Embryo Biotechnology Laboratory, Dental Research Institute, Seoul National University School of Dentistry) ;
  • Roh, Sangho (Cellular Reprogramming and Embryo Biotechnology Laboratory, Dental Research Institute, Seoul National University School of Dentistry)
  • Received : 2021.05.21
  • Accepted : 2021.06.16
  • Published : 2021.06.30
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Abstract

Salivary glands are exocrine glands that secrete saliva into the oral cavity, and secreted saliva plays essential roles in oral health. Therefore, maintaining the salivary glands in an intact state is required for proper production and secretion of saliva. To investigate a specific signaling pathway that might affect the maintenance of mouse submandibular gland (SMGs), RNA sequencing was performed. In SMGs, downregulated expression patterns of Rho-associated protein kinase (ROCK) signaling pathway-related genes, including Rhoa, Rhob, Rhoc, Rock1, and Rock2, were observed. Gene expression profiling analyses of these genes indicate that the ROCK signaling pathway is a potential signal for SMG maintenance.

Keywords

Acknowledgement

This work was supported by a grant from the National Research Foundation of Korea (NRF-2020R1F1A1070433).

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