DOI QR코드

DOI QR Code

Osteoporotic Vertebral Compression Fracture Associated with Pregnancy and Lactation in Young Women

젊은 여성에서 임신 및 수유와 연관된 골다공증성 척추 압박골절

  • Received : 2020.06.11
  • Accepted : 2020.08.26
  • Published : 2021.06.30

Abstract

Osteoporosis associated with pregnancy and lactation is a rare disease that can cause osteoporotic vertebral compression fracture (OVCF). Patients usually complain of severe back pain, which is easily mistaken for pain due to pregnancy, childbirth, and lactation, making a rapid diagnosis and treatment difficult. The authors diagnosed OVCF related to pregnancy and lactation through a physical examination, simple radiography, whole-body bone scan, magnetic resonance image, bone marrow density, and blood tests in a 29-year-old female patient and a 31-year-old female patient who presented with low back pain. This paper reports two cases of symptom improvement through a teriparatide injection, wearing thoracic lumbar sacral orthosis and taking calcium and vitamin D with a review of the literature.

임신 및 수유와 연관된 골다공증은 젊은 여성에서 골다공증성 척추 압박골절을 일으킬 수 있는 희귀한 질환이다. 환자들은 주로 요통을 호소하며, 이는 임신과 출산, 수유에 의한 통증으로 오인되기 쉬워 빠른 진단과 치료가 어렵다. 저자들은 요통을 주소로 내원한 29세 여자 환자와 31세 여자 환자에 대해 신체 진찰, 단순 방사선 검사, 전신 골주사 검사, 자기공명영상 검사, 골밀도 검사, 혈액 검사 등을 통하여 임신과 수유에 연관된 골다공증성 척추 압박골절을 진단하였으며, 테리파라타이드(teriparatide) 주사와 흉요천추 보조기 착용, 칼슘과 비타민 D 제제 복용을 통해 증상이 호전된 2예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

Keywords

References

  1. Smith R, Athanasou NA, Ostlere SJ, Vipond SE. Pregnancy-associated osteoporosis. QJM. 1995;88:865-78.
  2. Hadji P, Boekhoff J, Hahn M, Hellmeyer L, Hars O, Kyvernitakis I. Pregnancy-associated osteoporosis: a case-control study. Osteoporos Int. 2017;28:1393-9. https://doi.org/10.1007/s00198-016-3897-8
  3. Kohlmeier L, Marcus R. Calcium disorders of pregnancy. Endocrinol Metab Clin North Am. 1995;24:15-39. https://doi.org/10.1016/s0889-8529(18)30052-5
  4. Kovacs CS, Ralston SH. Presentation and management of osteoporosis presenting in association with pregnancy or lactation. Osteoporos Int. 2015;26:2223-41. https://doi.org/10.1007/s00198-015-3149-3
  5. Ozturk C, Atamaz FC, Akkurt H, Akkoc Y. Pregnancy-associated osteoporosis presenting severe vertebral fractures. J Obstet Gynaecol Res. 2014;40:288-92. https://doi.org/10.1111/jog.12157
  6. Winarno AS, Kyvernitakis I, Hadji P. Successful treatment of 1-34 parathyroid hormone (PTH) after failure of bisphosphonate therapy in a complex case of pregnancy associated osteoporosis and multiple fractures. Z Geburtshilfe Neonatol. 2014;218:171-3. https://doi.org/10.1055/s-0034-1382069
  7. Sowers M. Pregnancy and lactation as risk factors for subsequent bone loss and osteoporosis. J Bone Miner Res. 1996;11:1052-60. https://doi.org/10.1002/jbmr.5650110803
  8. Hellmeyer L, Boekhoff J, Hadji P. Treatment with teriparatide in a patient with pregnancy-associated osteoporosis. Gynecol Endocrinol. 2010;26:725-8. https://doi.org/10.3109/09513591003649831
  9. Hwang SH, Woo YK, Jeon HS, Suh SP, Kim JY, Kim JN. Treatment effect with weekly teriparatide in the vertebral compression fractures in patients with severe osteoporosis. J Korean Orthop Assoc. 2019;54:528-36. https://doi.org/10.4055/jkoa.2019.54.6.528
  10. Bayram S, Ozturk C, Sivrioglu K, Aydinli U, Kucukoglu S. Kyphoplasty for pregnancy-associated osteoporotic vertebral fractures. Joint Bone Spine. 2006;73:564-6. https://doi.org/10.1016/j.jbspin.2005.11.015