Advances in nano research

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Separation of tumor cells from the peripheral blood via a novel electro hydrodynamics model

  • Li, Xin (School of Clinical Medicine, Weifang Medical University) ;
  • Liu, Yanping (Physical Examination Center, Qingdao Municipal Hospital (West)) ;
  • Wang, Yingcui (Department of Cardiology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University) ;
  • Zou, Caixia (Internal Medicine Nursing, Qingdao Municipal Hospital (West))
  • Received : 2020.09.16
  • Accepted : 2021.05.18
  • Published : 2021.06.25
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Abstract

The significant issue that has been investigated in this research due to the great clinical potential is to separate a circulating tumor cells (CTCs) from the peripheral blood and cancer treatment in advance. Nonetheless, it is difficult to detect CTCs because of the rare existence of CTCs in the middle of peripheral blood. It is found that the need of high resolution ethods is crucial because there is a similarity in size range between CTCs types such as the cells of breast cancer and the white blood cells (WBCs). This paper presents a device which can be used for tumor cells separation from the cells of blood with nonstop flow that is helped by fractionating dielectrophoresis (DEP) field-flow. The reason that leads CTCs to separate from the cells of blood is the obvious different sizes of hydrodynamics focusing and dielectrophoretic force. Numerous attempts have been made to calculate CTCs trajectories with the aid of simulating the flow speed and electric field and it reveals an accurate comparison of them with the measured results. Furthermore, the low applied voltage such 10 Vpp with which the represented device can be utilized. The high precision and efficiency of particle separation can be obtained by the device as well. According to the differences in size, this approach has various application for separation of other particles sorts. Based on our findings in this study, it is assumed that our device is beneficial for studying cancer and also has an excellent capability of separating tumor cells from blood cells.

Keywords

Acknowledgement

This work was supported by People's Livelihood Science and Technology Project of Qingdao (No.19-6-1-26-nsh); Key Fund of Department of Cardiology, Shandong University Qilu Hospital (Qingdao) (QDKY2019ZD04), People's Livelihood Science and Technology Project of Qingdao (Application of DEEPVESSEL FFR in coronary artery heart disease complicated with diabetes mellitus), Qingdao Key Health Discipline Developent Fund.

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