Journal of the Korean Society of Radiology (대한영상의학회지)

The Korean Society of Radiology (대한영상의학회)
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Early and Atypical Radiologic Presentations of Pulmonary Langerhans Cell Histiocytosis: A Report of Two Cases

폐 랑게르한스 조직구 증식증의 비전형적 영상 소견: 2예에 대한 보고

  • Kyunghwa Ryu (Department of Radiology, Soonchunhyang University Seoul Hospital) ;
  • Bo Da Nam (Department of Radiology, Soonchunhyang University Seoul Hospital) ;
  • Jung Hwa Hwang (Department of Radiology, Soonchunhyang University Seoul Hospital) ;
  • Dong Won Kim (Department of Pathology, Soonchunhyang University Seoul Hospital) ;
  • Young Woo Park (Department of Cardiothoracic Surgery, Soonchunhyang University Seoul Hospital) ;
  • Hong Chul Oh (Department of Cardiothoracic Surgery, Soonchunhyang University Seoul Hospital) ;
  • Soo Bin Park (Department of Nuclear Medicine, Soonchunhyang University Seoul Hospital)
  • 유경화 (순천향대학교 서울병원 영상의학과) ;
  • 남보다 (순천향대학교 서울병원 영상의학과) ;
  • 황정화 (순천향대학교 서울병원 영상의학과) ;
  • 김동원 (순천향대학교 서울병원 병리과) ;
  • 박영우 (순천향대학교 서울병원 흉부외과) ;
  • 오홍철 (순천향대학교 서울병원 흉부외과) ;
  • 박수빈 (순천향대학교 서울병원 핵의학과)
  • Received : 2020.03.31
  • Accepted : 2020.08.09
  • Published : 2021.05.01
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Abstract

Pulmonary Langerhans cell histiocytosis (PLCH) is a rare, multi-systemic disease primarily affecting young male adults with a history of smoking. The two patients with PLCH in our report showed relatively early and atypical radiologic presentations at initial evaluation. On chest CT, PLCH presents variable radiologic features depending on the evolutional stage of the disease. Atypical CT features of PLCH may render precise radiologic diagnosis difficult and usually require lung biopsy for a confirmation of the diagnosis. Our case review is aimed at raising the awareness of radiologists on the atypical CT features of PLCH, to help make accurate radiologic diagnosis and prevent unnecessary and invasive diagnostic procedures.

폐의 랑게르한스 조직구 증식증은 드문 질환으로 주로 흡연력이 있는 젊은 성인 남성에서 발생한다. 이번 증례 보고는 폐 랑게르한스 조직구 증식증 2예에 대한 보고이며 이들은 모두 초기 검사에서 비전형적인 영상 소견을 보였다. 흉부 전산화단층촬영에서 폐 랑게르한스 조직구 증식증은 질환의 침범 정도와 시기에 따라 다양한 소견을 보일 수 있으며, 때로 악성 질환을 포함한 다른 중요 폐 질환들과 감별이 필요하고 영상 진단에 어려움을 줄 수 있다. 따라서, 이번 증례 보고를 통하여 폐 랑게르한스 조직구 증식증의 초기 및 비전형적인 영상 소견을 숙지함으로써 정확한 영상 진단에 도움을 주고 불필요하고 침습적인 검사를 줄일 수 있을 것으로 생각된다.

Keywords

Acknowledgement

This research was supported by the Soonchunhyang University Research Fund.

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