DOI QR코드

DOI QR Code

A Case of Laryngeal Lymphoepithelial Carcinoma

후두에 발생한 림프상피암종 1예

  • Choi, Dong Gyu (Department of Otolaryngology-Head and Neck Surgery, Kosin University College of Medicine) ;
  • Kim, Young-Ok (Department of Pathology, Kosin University College of Medicine) ;
  • Lee, Hyoung Shin (Department of Otolaryngology-Head and Neck Surgery, Kosin University College of Medicine)
  • 최동규 (고신대학교 의과대학 이비인후-두경부외과학교실) ;
  • 김영옥 (고신대학교 의과대학 병리학교실) ;
  • 이형신 (고신대학교 의과대학 이비인후-두경부외과학교실)
  • Received : 2020.10.21
  • Accepted : 2020.11.18
  • Published : 2021.04.30

Abstract

Laryngeal lymphoepithelial carcinoma (LEC) is a rare tumor with only 34 cases in the published literature. Epidemiologically, laryngeal LEC is extremely rare in Asian. Originally, LEC is a common type of carcinoma in nasopharynx. Laryngeal LEC resembles nasopharyngeal LEC, except that most cases of laryngeal LEC are not associated with Epstein-Barr virus. We present a case of laryngeal LEC which developed at the left false cord extending to true vocal cord, para-glottic space and pre-epiglottic space. Total laryngectomy with bilateral neck dissection was performed. LEC was reported as biopsy confirmation result. The patient underwent postoperative radiotherapy and showed no evidence of recurrence during follow-up period of 42 months. In consideration that LEC in larynx have not been reported in South Korea yet, we introduce the clinical features and treatment outcomes of laryngeal LEC with literature review.

Keywords

References

  1. Kermani W, Belcadhi M, Sriha B, Abdelkefi M. Epstein-Barr virus-associated lymphoepithelial carcinoma of the larynx. Eur Ann Otorhinolaryngol Head Neck Dis 2015;132(4):231-3. https://doi.org/10.1016/j.anorl.2015.05.004
  2. Hammas N, Benmansour N, El Alami El Amine MN, Chbani L, El Fatemi H. Lymphoepithelial carcinoma: a case report of a rare tumor of the larynx. BMC Clin Pathol 2017;17:24. https://doi.org/10.1186/s12907-017-0061-0
  3. Monteiro F, Baldaia H, Ribeiro L, Sousa M, Oliveira P, Ferreira E, et al. Epstein-Barr virus-associated with lymphoepithelial carcinoma: a rare tumor of the larynx. Clin Med Insights Ear Nose Throat 2019;12:1179550619865551.
  4. Faisal M, Hartenbach S, Schratter A, Kostler WJ, Kaufmann H, Seemann R, et al. Lymphoepithelial carcinoma of larynx and hypopharynx: a rare clinicopathological entity. Cancers (Basel) 2020;12(9):2431.
  5. Coskun BU, Cinar U, Sener BM, Dadas B. Lymphoepithelial carcinoma of the larynx. Auris Nasus Larynx 2005;32(2):189-93. https://doi.org/10.1016/j.anl.2004.11.014
  6. Chen YP, Chan ATC, Le QT, Blanchard P, Sun Y, Ma J. Nasopharyngeal carcinoma. Lancet 2019;394(10192):64-80. https://doi.org/10.1016/s0140-6736(19)30956-0
  7. Marioni G, Mariuzzi L, Gaio E, Portaleone S, Pertoldi B, Staffieri A. Lymphoepithelial carcinoma of the larynx. Acta Otolaryngol 2002;122(4):429-34.
  8. MacMillan C, Kapadia SB, Finkelstein SD, Nalesnik MA, Barnes L. Lymphoepithelial carcinoma of the larynx and hypopharynx: study of eight cases with relationship to Epstein-Barr virus and p53 gene alterations, and review of the literature. Hum Pathol 1996;27(11):1172-9. https://doi.org/10.1016/S0046-8177(96)90311-1
  9. Ibrahimov M, Yilmaz M, Celal MH, Mamanov M, Yollu U, Ozek H. Lymphoepithelial carcinoma of the larynx. J Craniofac Surg 2013;24(3):1049.
  10. Acuna G, Goma M, Temprana-Salvador J, Garcia-Bragado F, Alos L, Ordi J, et al. Human papillomavirus in laryngeal and hypopharyngeal lymphoepithelial carcinoma. Mod Pathol 2019;32(5):621-26. https://doi.org/10.1038/s41379-018-0188-2