Anxiety and mood (대한불안의학회지)

Korean Academy of Anxiety Disorders (대한불안의학회)
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Impairment of Working Memory in Patients with Panic Disorder

공황장애 환자에서의 작업기억 장애

  • Chae, Seung-Hui (Department of Psychiatry, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine) ;
  • Shin, Young-Chul (Department of Psychiatry, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine) ;
  • Shin, Dong-Won (Department of Psychiatry, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine) ;
  • Oh, Kang-Seob (Department of Psychiatry, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine) ;
  • Jeon, Sang-Won (Department of Psychiatry, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine) ;
  • Cho, Sung Joon (Department of Psychiatry, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine)
  • 채승희 (성균관대학교 의과대학 강북삼성병원 정신건강의학교실) ;
  • 신영철 (성균관대학교 의과대학 강북삼성병원 정신건강의학교실) ;
  • 신동원 (성균관대학교 의과대학 강북삼성병원 정신건강의학교실) ;
  • 오강섭 (성균관대학교 의과대학 강북삼성병원 정신건강의학교실) ;
  • 전상원 (성균관대학교 의과대학 강북삼성병원 정신건강의학교실) ;
  • 조성준 (성균관대학교 의과대학 강북삼성병원 정신건강의학교실)
  • Received : 2021.03.02
  • Accepted : 2021.04.19
  • Published : 2021.04.30
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Abstract

Objective : The purpose of this study was to investigate the impairment of working memory in patients with panic disorder through neuropsychological examination. Methods : A total of 38 patients who met the DSM-5 criteria for panic disorder and 40 healthy controls were recruited in this study. Controls and patients were matched for age, sex, and education. The Hamilton Anxiety Rating Scale (HAMA), the Hamilton Depression Rating Scale (HAMD), and the Panic Disorder Severity Scale (PDSS) were used to evaluate the severities of anxiety, depression, and panic disorder. Further, the digit span task was performed to assess working memory. In addition, a sub-analysis was performed after excluding participants with clinical depressive symptoms. Finally, a sub-analysis by the education level was performed. Results : The HAMA, HAMD, and PDSS scores were significantly higher for patients with panic disorder compared to controls. The scores of digit span forward, digit span backward, digit span sequencing, and total digit span were significantly lower for patients with panic disorder compared to controls. In the sub-analyses excluding patients with depression and by education level, the score of total digit span was significantly lower for patients with panic disorder compared to controls. Conclusion : In this study, patients with panic disorder had deficits in working memory compared to healthy controls.

Keywords

Acknowledgement

본 연구를 설계해주신 고(故) 임세원 교수님께 감사합니다. 저자들은 본 연구에 기여한 고(故) 임세원 교수님의 열정과 정신을 기립니다.

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