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Risk Factor of Mood Disorder Development in Breast Cancer Survivors

유방암 생존자의 기분장애 발생 위험요인

  • Park, Min Ae (Medical Informatics and health Technology (MIT), Department of Health Care Management, College of Social Science, Gachon University) ;
  • Seo, Hwa Jeong (Medical Informatics and health Technology (MIT), Department of Health Care Management, College of Social Science, Gachon University)
  • 박민애 (가천대학교 사회과학대학 의료경영학과) ;
  • 서화정 (가천대학교 사회과학대학 의료경영학과)
  • Received : 2020.08.13
  • Accepted : 2020.12.15
  • Published : 2021.04.30

Abstract

Objective : The questionnaire-based study model has a problem in that there is no information on diseases and drugs to determine the association between mood disorders and the severity of comorbid diseases in cancer survivors. This study used claim data collected by the National Health Insurance Corporation over nine years to identify risk factors of mood disorders in breast cancer survivors Methods : 2,065 patients were included in this study, excluding someone who were diagnosed mood disorders one year before breast cancer diagnosis. All statistical analysis was performed with R4.0.0 Chi-Square test and Cox's proportional hazards model was performed. Results : Chi-square test was performed to confirm the general characteristics of the subjects. There were 461 (22.32%) patients with mood disorders and 1,604 (77.67%) patients with no mood disorders. In the univariate Model 1 according to the CCI, the HR in the case of CCI 2 was analyzed as 1.629(95% CI, 1.15-2.30), CCI≥3 was analyzed as 2.031(95% CI 1.48-2.78), compared to the study subjects with CCI=0. The age and survivorship adjusted Model 2 HR, CCI=2 was 1.615(95% CI, 1.14-2.28), CCI≥3 was analyzed as 1.924 (95% CI 1.40-2.65). The fully adjusted Model 3 HR, CCI=2 was 1.599 (95% CI, 1.12-2.28), CCI≥3 was analyzed as 1.760 (95% CI 1.25-2.49). Conclusion : In order to improve the long-term quality of life for breast cancer survivors in the future, it is necessary to manage survivorship, the severity of comorbidities, which are identified as risk factors for the development of mood disorders.

Keywords

Acknowledgement

This study was supported by a grant from the National R&D Program for Cancer Control, Ministry of Health & Welfare, Republic of Korea (1420210) and funded by the Ministry of Science, ICT & Future Planning (NRF-2017R1A2B4006545).

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