한국발생생물학회지:발생과생식 (Development and Reproduction)

  • 제25권4호
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  • Pages.235-244
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  • 2021
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  • 2465-9525(pISSN)
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  • 2465-9541(eISSN)
한국발생생물학회 (The Korean Society of Developmental Biology)
권호 표지
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Analysis of Tissue-Specific Interferon Regulatory Factor 3 (IRF3) Gene Expression against Viral Infection in Paralichthys olivaceus

  • Kim, Kyung-Hee (Fish Genetics and Breeding Research Center, National Institute of Fisheries Science) ;
  • Lee, Sanghyun (Fish Genetics and Breeding Research Center, National Institute of Fisheries Science) ;
  • Park, Jong-Won (Fish Genetics and Breeding Research Center, National Institute of Fisheries Science) ;
  • Jung, Hyo Sun (Fish Genetics and Breeding Research Center, National Institute of Fisheries Science) ;
  • Kim, Julan (Fish Genetics and Breeding Research Center, National Institute of Fisheries Science) ;
  • Yang, Hyerim (Fish Genetics and Breeding Research Center, National Institute of Fisheries Science) ;
  • Lee, Jeong-Ho (Fish Genetics and Breeding Research Center, National Institute of Fisheries Science) ;
  • Lee, Dain (Fish Genetics and Breeding Research Center, National Institute of Fisheries Science)
  • 투고 : 2021.08.29
  • 심사 : 2021.11.23
  • 발행 : 2021.12.31
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초록

Interferon Regulatory Factor 3 (IRF3) is a member of interferon-regulated transcription factor family and is known to play an important role in the innate immune response against viral infections. In this study, the expression of IRF3 in different tissues, developmental stages, and stocking densities of olive flounder was investigated. The expression of IRF3 was observed to gradually increase in early-stage juvenile fish. The highest expression was observed in later-stage juvenile fish when immune tissues were formed. High IRF3 expression was observed in the muscles and the brain tissues. The expression of IRF3 was observed in fish at different stocking densities after viral hemorrhagic septicemia virus (VHSV) infection. It yielded an interesting expression pattern in the muscles and the brain tissues of fish stocked at low density. These observations can be used as basic data for the study of the expression of immune response-related genes against viruses based on stocking density and immune systems in other fish species.

키워드

과제정보

This work was supported by a grant from the National Institute of Fisheries Science (R2021001).

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