공업화학 (Applied Chemistry for Engineering)

  • 제32권2호
  • /
  • Pages.132-138
  • /
  • 2021
  • /
  • 1225-0112(pISSN)
  • /
  • 2288-4505(eISSN)
한국공업화학회 (The Korean Society of Industrial and Engineering Chemistry)
권호 표지
DOI QR코드

DOI QR Code

Pinus densiflora와 Pinus koraiensis로부터 분리된 생리활성 물질들 및 응용

Bioactive Compounds Isolated from Pinus densiflora and koraiensis and their Applications

  • 김남희 ((주)대산) ;
  • 윤순권 ((주)천년관솔) ;
  • 엄병헌 (한국과학기술연구원 천연물연구소) ;
  • 김정원 (강원대학교 에너지공학부(에너지화학공학전공))
  • 투고 : 2021.03.22
  • 심사 : 2021.03.25
  • 발행 : 2021.04.10
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

본 리뷰에서는 대한민국에서 자생하고 있는 소나무와 잣나무들로부터 분리·추출되는 생리활성 물질의 종류, 그리고 그 효과성에 대한 연구 현황 및 산업적 활용에 대해 조사하였다. 소나무와 잣나무에는 정유, 폴리페놀, 레진, 스틸벤 유도체를 비롯한 다양한 생리활성 물질들이 함유되어 있다. 최근 국내 연구진들은 소나무와 잣나무의 추출물들로부터 항산화, 항염증, 항균, 백내장 예방, 신경보호 등의 생리활성을 규명하였다. 그 추출물들은 식품, 건강기능식품, 화장품, 생활용품 등의 다양한 산업 분야에서 활용되고 있으나, 산업적으로 높은 비중을 차지하고 있는 것은 외래종을 원료로 한 것이다. 그러므로 과학적으로 규명되고 있는 효과에 비해 생리활성을 실제 제품에 응용한 사례들이 부족하여 산업적 활용성에 대한 다양한 연구가 필요하다.

This review investigated the types of physiologically active substances isolated and extracted from Pinus densiflora and koraiensis native to Republic of Korea, and the current status of research on their effectiveness and industrial use. They contain various bioactive substances including essential oils, polyphenols, resins, and stilbene derivatives. In recent, physiological activities such as antioxidant, anti-inflammatory, antibacterial, cataract prevention, and neuroprotection from extracts of Pinus densiflora and koraiensis have been identified by domestic researchers. The extracts have been used in different industrial fields like food, health functional foods, cosmetics, and household goods, but the high proportion of them is industrially made from exotic species. Therefore, various studies on industrial applicability are needed due to the lack of cases in which the activity is applied to actual products, with respect to the effects that have been scientifically recognized.

키워드

참고문헌

  1. O. Kwon, Science of Life, Life of Science, 63-70, Korean Library Association, Republic of Korea (2008).
  2. S. K. Lee, H. J. Lee, H. Y. Min, E. J. Park, K. M. Lee,Y. H. Ahn, Y. J. Cho, and J. H. Pyee, Antibacterial and antifungal activity of pinosylvin, a constituent of pine, Fitoterapia, 76, 258-260 (2005). https://doi.org/10.1016/j.fitote.2004.12.004
  3. H. J. Hwang, H. Y. Lee, W. Han, and S. Y. Kim, Evaluations on deodorization effect and anti-oral microbial activity of essential oil from Pinus koraiensis, Korean J. Plant Res., 27, 1-10 (2014). https://doi.org/10.7732/kjpr.2014.27.1.001
  4. T. E. Khawand, A. Courtois, J. Valls, and S. Krisa, A review of dietary stilbenes: Sources and bioavailability, Phytochem. Rev., 17, 1007-1029 (2018). https://doi.org/10.1007/s11101-018-9578-9
  5. M. M. Hasan, M. Cha, V. K. Bajpai, and K. Baek, Production of a major stilbene phytoalexin, resveratrol in peanut (Arachis hypogaea) and peanut products: A mini review, Rev. Environ. Sci. Biotechnol., 12, 209-221 (2013). https://doi.org/10.1007/s11157-012-9294-7
  6. I. Marmo, J. Quero, and C. Ancin-Azpilicueta, A systematic review of the potential uses of pine bark in food industry and health care, Trends Food Sci. Technol., 88, 558-566 (2019). https://doi.org/10.1016/j.tifs.2018.07.007
  7. D. S. Gernandt, G. G Lopez, S. O. Garcia, and A. Liston, Phylogeny and classification of Pinus, Taxon, 54, 29-42 (2005). https://doi.org/10.2307/25065300
  8. U. Zeb, W. Dong, T. Zhang, R. Wang, and Z.-H. Li, Comparative plastid genomics of Pinus species: Insights into sequence variations and phylogenetic relationships, J. Syst. Evol., 28, 1-15 (2019).
  9. W.-S. Kong, Biogeography of native Korean pinaceae, J. Geol. Soc. Korea, 41, 73-93(2006).
  10. B.-H. Hwang, H.-J. Lee, H.-Y. Kang, S. Liu, J.-H. Cho, and J. Zhao, Studies on the analysis of special components of major pine needles for searching of the new functional substances (I)-analysis of pectin, tannin and terpenoids, J. Forest Environ. Sci., 13, 134-142 (1997).
  11. H.-K. Song, Isolation and identification of stilbene glycosides from the bark of Pinus koraiensis, J. Korean Wood Sci. Technol., 29, 97-102 (2001).
  12. H.-Y. Ahn, S.-J. Heo, M.-J. Kang, J.-H. Lee, and Y.-S. Cho, Antioxidative activity and chemical characteristics of leaf and fruit extracts from Thuja orientalis, J. Life Sci., 21, 746- 752 (2011). https://doi.org/10.5352/JLS.2011.21.5.746
  13. N. Balasundram, K. Sundram, and S. Samman, Phenolic compounds in plants and agri-industrial by-products: Antioxidant activity, occurrence, and potential uses, Food Chem., 99, 191-203 (2006). https://doi.org/10.1016/j.foodchem.2005.07.042
  14. G. Park and Y. Kim, Hair growth-promoting effect of resina pini and its main constituent, abietic acid, in mouse model of alopecia, J. Soc. Cosmet. Scientists Korea, 42, 203-209 (2016). https://doi.org/10.15230/SCSK.2016.42.3.203
  15. J. O. Kim and N. Cho, Effects of 4% hypertonic saline solution mouthwash on oral health of elders in long term care facilities, J. Korean Biol. Nurs. Sci., 44, 13-20 (2014).
  16. J. Kim and S.-Y. Choung, Pinus densiflora bark extract prevents selenite-induced cataract formation in the lens of Sprague Dawley rat pups, Mol. Vis., 23, 638-648 (2017).
  17. J.-W. Kim, S. Im, H. Jeong, Y. S. Jung, I. Lee, and K. J. Kim, Neuroprotective effects of Korean red pine (Pinus densiflora) bark extract and its phenolics, J. Microbiol. Biotechnol., 28, 679-687 (2018). https://doi.org/10.4014/jmb.1801.01053
  18. J.-S. Kim, Evaluation of in vitro antioxidant activity of the water extract obtained from dried pine needle (Pinus densiflora), Prev. Nutr. Food Sci., 23, 134-143 (2018). https://doi.org/10.3746/pnf.2018.23.2.134
  19. T. Venkatesan, Y.-W. Choi, and Y.-K. Kim, Impact of different extraction solvents on phenolic content and antioxidant potential of Pinus densiflora bark extract, Biomed Res. Int., 2019, 1-14 (2019).
  20. S.-H. Park, K. Kim, M. Kim, J.-S. Choi, Y. Cho, and D.-H. Ahn, Antimicrobial activity of extracts from different parts and essential oil from Pinus densiflora on skin pathogens, J. Life Sci., 27, 646-651 (2017). https://doi.org/10.5352/JLS.2017.27.6.646
  21. D. G. Lee, S. J. Lee, J. P. Rodriguez, I. H. Kim, T. Chang, and S. Lee, Antifungal activity of pinosylvin from Pinus densiflora on turfgrass fungal diseases, J. Appl. Biol. Chem., 60, 213-218(2017). https://doi.org/10.3839/jabc.2017.034
  22. P. Rohdewald, A review of the French maritime pine bark extract (Pycnogenol), a herbal medication with a diverse clinical pharmacology, Int. J. Clin. Pharmacol. Ther., 40, 158-168 (2002). https://doi.org/10.5414/CPP40158
  23. G. D'Andrea, Pycnogenol: A blend of procyanidins with multifaceted therapeutic applications?, Fitoterapia, 81, 724-736 (2010). https://doi.org/10.1016/j.fitote.2010.06.011
  24. A. Sahebkar, A systematic review and meta-analysis of the effects of pycnogenol on plasma lipids, J. Cardiovasc. Pharmacol. Ther., 19, 244-255 (2014). https://doi.org/10.1177/1074248413511691
  25. S. Grether-Beck, A. Marini, T. Jaenicke, and J. Krutmann, French maritime pine bark extract (Pycnogenol®) effects on human skin: Clinical and molecular evidence, Skin Pharmacol. Physiol., 29, 13-17 (2016). https://doi.org/10.1159/000441039
  26. Y. Yazaki, Utilization of flavonoid compounds from bark and wood: A review, Nat. Prod. Commun., 10, 513-520 (2015).
  27. E. Icel, T. Ucak, B. Agcayazi, Y. Karakurt, H. Yilmaz, F. K. Cimen, and H. Suleyman, Effects of Pycnogenol on cisplatin-induced optic nerve injury: An experimental study, Cutan. Ocul. Toxicol., 37, 396-400 (2018). https://doi.org/10.1080/15569527.2018.1495224
  28. M.-J. Jeong, S.-J. Jeong, S.-H. Lee, Y.-S. Kim, B.-D. Choi, and S.-H. Kim, Effect of pycnogenol on skin wound healing, Appl. Microsc., 43, 133-139 (2013). https://doi.org/10.9729/AM.2013.43.4.133
  29. W. Dridi and N. Bordenave, Pine bark phenolic extracts, current uses, and potential food applications: A review, Curr. Pharm. Des., 26, 1866-1879 (2020). https://doi.org/10.2174/1381612826666200212113903
  30. W. E. Hillis, Heartwood and Tree Exudates, 100-201, Springer Science & Business Media (2012).