Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Changes of Prosapogenin Components in Tienchi Seng (Panax notoginseng) by Ultrasonic Thermal Fusion Process

  • Lee, Jae Bum (Department of Oriental Medical Food & nutrition, Semyung University) ;
  • Yang, Byung Wook (School of Industrial Bio-Pharmaceutical Science, Semyung University) ;
  • Kim, Do Hyeong (Department of Oriental Medical Food & nutrition, Semyung University) ;
  • Jin, Dezhong (International Education College, Jiangxi University of Traditional Chinese Medicine) ;
  • Ko, Sung Kwon (Department of Oriental Medical Food & nutrition, Semyung University)
  • Received : 2020.11.18
  • Accepted : 2021.02.05
  • Published : 2021.03.31
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Abstract

The purpose of this study is to develop a new method of producing tienchi seng (notoginseng, Panax notoginseng) extracts featuring high concentrations of the ginsenoside Rg3, Rg5, and Rg6, special components of Korean red ginseng. The chemical transformation from ginseng saponin glycosides to prosapogenin was analyzed by HPLC. Tienchi seng was heat-processed at 100℃ and the optimum conditions were identified. The highest concentrations of total saponin (29.723%) and the ginsenoside Rg3 (1.769%), Rg5 (5.979%), and Rg6 (13.473%) were produced at 48 hours. Also, when tienchi seng was subjected to the ultrasonic thermal fusion (100℃) process, the concentrations of total saponin (30.578%), ginsenoside Rg3 (2.392%), Rg5 (6.614%), and Rg6 (13.017%) were highest at 36 hours. On the other hand, the 2-hour heat-processed extract and 2-hour ultrasonic thermal fusion-processed extract did not contain ginsenoside Rg3, Rg5, and Rg6. The ultrasonic thermal fusion process had an extraction yield that was approximately 1.26 times greater than that of the heat process. These results indicate that the highly functional tienchi seng extracts created through the ultrasonic thermal fusion process are more industrially useful than those produced using the heat process.

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References

  1. Ko, S. K.; Im, B. O. The science of Korean ginseng; Yakupsinmunsa: Korea, 2009, p 47.
  2. Chen, F. H. Cardiovasscular Division. Treatment of angina pectoris and animal experiments of Panax notoginseng (Burk) National coronary Heart Diseases Conference; China People's Health Publishing House: China, 1974, p 262.
  3. Park, J. A.; Choi, S. H.; Ahn, K. S.; Moon, J. J. Korean Journal of Oriental Medical Pathology 1992, 7, 15-26.
  4. Wakabayashi, C.; Hasegawa, H.; Murata, J.; Saiki, I. Oncol. Res. 1997, 9, 411-417.
  5. Chan, R. Y. K.; Chen, W. F.; Dong, A.; Guo, D.; Wong, M. S. W. J. Clin. Endocrinol. Metab. 2002, 87, 3691-3695. https://doi.org/10.1210/jc.87.8.3691
  6. Ng, T. B. J. Pharm. Pharmacol. 2006, 58, 1007-1019. https://doi.org/10.1211/jpp.58.8.0001
  7. Shin, J. C.; Moon, J. Y.; Park, W. H. Korean J. Oriental Physiology and Pathology 2006, 20, 724-729.
  8. Xie, J. T.; Aung, H. H.; Wang, C. Z.; Mehendale, S. R.; McEntee, E.; Wicks, S.; Li, J.; Yuan, C. S. Oriental Pharmacy and Experimental Medicine 2006, 6, 286-292. https://doi.org/10.3742/OPEM.2006.6.4.286
  9. Kim, J. G.; Park, S. D.; Park, W. H. Korean J. Physiology & Pathology 2006, 20, 1187-1195.
  10. Gao, R. L.; Lin, X. J.; Chen, X. H. Zhongguo Zhong Xi Yi Jie He Za Zhi 2007, 27, 999-1003.
  11. Jin, U. H.; Park, S. G.; Suh, S. J.; Kim, J. K.; Kim, D. S.; Moon, S. K.; Lee, Y. C.; Park, W. H.; Kim, C. H. Phytother. Res. 2007, 21, 142-148. https://doi.org/10.1002/ptr.2018
  12. Park, Y. K.; Jung, H. W. Kor. J. Herbology 2006, 21, 93-101.
  13. Lee, J. Y.; Lee, J. H. Korean J. Orient. Int. Med. 2011, 32, 1-9.
  14. Uzayisenga, R.; Ayeka, P. A.; Wang, Y. Phytother. Res. 2014, 28, 510-516. https://doi.org/10.1002/ptr.5026
  15. Duan, L.; Xiong, X.; Hu, J.; Liu, Y.; Wang, J. Phytomedicine 2018, 47, 23-33. https://doi.org/10.1016/j.phymed.2018.04.044
  16. Wang, Y. R.; Kim, E. S.; Lee, J. A. J. Korean Society of Cosmetology 2018, 24, 1014-1020.
  17. Park, J. D. Korean . J. Ginseng Sci. 1996, 20, 389-415.
  18. Bai, C.; Chai, X.; Gao, X.; Li, P.; Tu, P. China Journal of Chinese Materia Medica 2009, 34, 677-680.
  19. Lee, S. A.; Liu, T.; Jo, H. K.; Im, B. O.; Cho, S. H.; Whang, W. K.; Ko, S. K. Kor. J. Pharmacogn. 2010, 41, 319-322.
  20. Jo, H. K.; Cho, S. H.; Ko, S. K. Kor. J. Pharmacogn. 2014, 45, 320-325.
  21. Lee, J. B.; Ko, S. K. The Korean Society of Cosmetics and Cosmetology 2018, 6, 41-48.
  22. Hong, J. T.; Nam, Y. M.; Kim, S. J.; Ko, S. K. Yakhak Hoeji 2016, 60, 58-63. https://doi.org/10.17480/psk.2016.60.2.58
  23. Nam, Y. M.; Shin, H. J.; Yang, B. W.; Park, J. D.; Cho, S. H.; Kim, H. C.; Ko, S. K. Kor. J. Pharmacogn. 2016, 47, 352-359.
  24. Nam, Y. M.; Kwon, J. H.; Hong, J. T.; Yang, B. W.; Ko, S. K. Kor. J. Pharmacogn. 2016, 47, 73-78.
  25. Kim, S. J.; Kim, J. D.; Ko, S. K. The Korean Society of Cosmetics and Cosmetology 2017, 7, 121-127.
  26. Jo, H. K.; Im, B. O.; Ko, S. K. Kor. J. Pharmacogn. 2014, 45, 77-83.
  27. Jo, H. K.; Gwak, H. H.; Im, B. O.; Cho, S. H.; Ko, S. K. Kor. J. Pharmacogn. 2014, 45, 107-112.
  28. Kim, S. J.; Kim, J. D.; Ko, S. K. Kor. J. Pharmacogn. 2013, 44, 149-153.
  29. Yoon, S. H.; Nam, Y. M.; Hong, J. T.; Kim, S. J.; Ko, S. K. J. Ginseng Res. 2016, 40, 300-303. https://doi.org/10.1016/j.jgr.2015.09.001
  30. Keum, Y. S.; Han, S. S.; Chun, K. S.; Park, K. K.; Park, J. H.; Lee, S. K.; Surh, Y. J. Mutat. Res. 2003, 523-524, 75-85. https://doi.org/10.1016/S0027-5107(02)00323-8
  31. Kim, N. D.; Kang, S. Y.; Park, J. H.; Schini-Kerth, V. B. Eur. J. Pharmacol. 1999, 367, 41-49. https://doi.org/10.1016/S0014-2999(98)00898-X
  32. Yang, L.; Hao, J.; Zhang, J.; Xia, W.; Dong, X.; Hu, X.; Kong, F.; Cui, X. J. Pharm. Pharmacol. 2009, 61, 375-380. https://doi.org/10.1211/jpp/61.03.0013
  33. Lee, W. M.; Kim, S. D.; Park, M. H.; Cho, J. Y.; Park, H. J.; Seo, G. S.; Rhee, M. H. J. Pharm. Pharmacol. 2008, 60, 1531-1536. https://doi.org/10.1211/jpp/60.11.0015
  34. Keum, Y. S.; Park, K. K.; Lee, J. M.; Chun, K. S.; Park, J. H.; Lee, S. K.; Kwon, H.; Surh, Y. J. Cancer Lett. 2000, 150, 41-48. https://doi.org/10.1016/S0304-3835(99)00369-9
  35. Shin, D. H.; Cha, Y. J.; Yang, K. E.; Jang, I. S.; Son, C. G.; Kim, B. H.; Kim, J. M. Phytotherapy Res. 2014, 28, 1088-1095. https://doi.org/10.1002/ptr.5101
  36. Lim, C. J.; Choi, W. Y.; Jung, H. J. Biol. Pharm. Bull. 2014, 37, 1583-1590. https://doi.org/10.1248/bpb.b14-00167
  37. Lee, Y. Y.; Park, J. S.; Jung, J. S.; Kim, D. H.; Kim, H. S. Int. J. Mol. Sci. 2013, 14, 9820-9833. https://doi.org/10.3390/ijms14059820
  38. Lee, S. M. Phytother. Res. 2014, 28, 1893-1896. https://doi.org/10.1002/ptr.5203
  39. Chu, S.; Gu, J.; Feng, L.; Liu, J.; Zhang, M.; Jia, X.; Liu, M.; Yao, D. Int. Immunopharmacol. 2014, 19, 317-326. https://doi.org/10.1016/j.intimp.2014.01.018
  40. Kim, S. J.; Kim, A. K. J. Ginseng Res. 2015, 39, 125-134. https://doi.org/10.1016/j.jgr.2014.09.003
  41. Li, W.; Yan, M. H.; Liu, Y.; Liu, Z.; Wang, Z.; Chen, C.; Zhang, J.; Sun, Y. S. Nutrients 2016, 8, 566. https://doi.org/10.3390/nu8090566
  42. Kim, S. J.; Shin, J. Y.; Ko, S. K. J. Ginseng Res. 2016, 40, 86-89. https://doi.org/10.1016/j.jgr.2015.04.008
  43. Chin, Bin.; Jix, X. B. Molecules 2013, 18, 8109-8119. https://doi.org/10.3390/molecules18078109