Journal of Convergence Korean Medicine (대한융합한의학회지)

Academy of Convergence Korean Medicine (대한융합한의학회)
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Effect of Polygonatum sibiricum Rehd. pharmacopuncture on localized adiposity in obese mice

황정 약침의 비만 쥐에서의 국소 지방분해 효능 연구

  • Mi Hye Kim (Department of Convergence Korean Medical Science, College of Korean Medicine, Kyung Hee University) ;
  • Tae Yang Choi (Department of Convergence Korean Medical Science, College of Korean Medicine, Kyung Hee University) ;
  • Woong Mo Yang (Department of Convergence Korean Medical Science, College of Korean Medicine, Kyung Hee University)
  • 김미혜 (경희대학교 한의과대학 융합한의과학교실) ;
  • 최태양 (경희대학교 한의과대학 융합한의과학교실) ;
  • 양웅모 (경희대학교 한의과대학 융합한의과학교실)
  • Received : 2021.05.19
  • Accepted : 2021.06.25
  • Published : 2021.06.30
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Abstract

Objectives: Excessive accumulation of fat on specific region, regarded as localized fat, is one of the serious problems and well-known risk factors of health. Recently, an interest in health and aesthetics is growing by treating lipolytic injection. Polygonatum sibiricum Rehd (PS) has been known to have anti-oxidant, -aging and -atherosclerotic effects. In this study, we investigated the lipolytic effects of PS pharmacopuncture in obese mice. Methods: Male C57BL/6J mice was fed with high fat diet to induce obesity for 12 weeks. PS pharmacopuncture was dissolved in saline by adjusting pH 7. 100 μL of PS pharmacopunture was injected subcutaneously into the left side inguinal fat pad, while saline was injected into the right side inguinal fat pad in mice as self-control. Samples were treated 3 times per weeks for 2 weeks. Results: PS pharmacopunture significantly decreased the inguinal fat weight compared to left side inguinal fat pad. Decrease rate of PS pharmacopuncture was about 21%. In addition, the diameter of adipocyte in inguinal fat tissues was significantly reduced by 17% compared to saline-injected side. There was no sign of toxicity through whole experiments. Conclusion: The present study indiates that PS pharmacopunture could be a material derived from natural herb as a lipolytic injection for decreasing localized fat.

Keywords

References

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