Journal of Gastric Cancer

The Korean Gastric Cancer Association (대한위암학회)
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Long-term Observation of Gastric Adenocarcinoma of Fundic Gland Mucosa Type before and after Helicobacter pylori Eradication: a Case Report

  • Takahashi, Keitaro (Gastroenterology and Endoscopy, Division of Metabolism and Biosystemic Science, Hematology/Oncology, Department of Medicine, Asahikawa Medical University) ;
  • Ueno, Nobuhiro (Gastroenterology and Endoscopy, Division of Metabolism and Biosystemic Science, Hematology/Oncology, Department of Medicine, Asahikawa Medical University) ;
  • Sasaki, Takahiro (Gastroenterology and Endoscopy, Division of Metabolism and Biosystemic Science, Hematology/Oncology, Department of Medicine, Asahikawa Medical University) ;
  • Kobayashi, Yu (Gastroenterology and Endoscopy, Division of Metabolism and Biosystemic Science, Hematology/Oncology, Department of Medicine, Asahikawa Medical University) ;
  • Sugiyama, Yuya (Gastroenterology and Endoscopy, Division of Metabolism and Biosystemic Science, Hematology/Oncology, Department of Medicine, Asahikawa Medical University) ;
  • Murakami, Yuki (Gastroenterology and Endoscopy, Division of Metabolism and Biosystemic Science, Hematology/Oncology, Department of Medicine, Asahikawa Medical University) ;
  • Kunogi, Takehito (Gastroenterology and Endoscopy, Division of Metabolism and Biosystemic Science, Hematology/Oncology, Department of Medicine, Asahikawa Medical University) ;
  • Ando, Katsuyoshi (Gastroenterology and Endoscopy, Division of Metabolism and Biosystemic Science, Hematology/Oncology, Department of Medicine, Asahikawa Medical University) ;
  • Kashima, Shin (Gastroenterology and Endoscopy, Division of Metabolism and Biosystemic Science, Hematology/Oncology, Department of Medicine, Asahikawa Medical University) ;
  • Moriichi, Kentaro (Gastroenterology and Endoscopy, Division of Metabolism and Biosystemic Science, Hematology/Oncology, Department of Medicine, Asahikawa Medical University) ;
  • Tanabe, Hiroki (Gastroenterology and Endoscopy, Division of Metabolism and Biosystemic Science, Hematology/Oncology, Department of Medicine, Asahikawa Medical University) ;
  • Kamikokura, Yuki (Department of Diagnostic Pathology, Asahikawa Medical University Hospital) ;
  • Yuzawa, Sayaka (Department of Diagnostic Pathology, Asahikawa Medical University Hospital) ;
  • Tanino, Mishie (Department of Diagnostic Pathology, Asahikawa Medical University Hospital) ;
  • Okumura, Toshikatsu (Gastroenterology and Endoscopy, Division of Metabolism and Biosystemic Science, Hematology/Oncology, Department of Medicine, Asahikawa Medical University) ;
  • Fujiya, Mikihiro (Gastroenterology and Endoscopy, Division of Metabolism and Biosystemic Science, Hematology/Oncology, Department of Medicine, Asahikawa Medical University)
  • Received : 2021.02.22
  • Accepted : 2021.03.22
  • Published : 2021.03.31
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Abstract

Gastric adenocarcinoma of the fundic gland mucosa type (GA-FGM) was proposed as a new variant of gastric adenocarcinoma of the fundic gland type (GA-FG). However, at present, the influence of Helicobacter pylori and the speed of progression and degree of malignancy in GA-FGM remain unclear. Herein, we report the first case of intramucosal GA-FGM that was endoscopically observed before and after H. pylori eradication over 15 years. The lesion showed the same tumor size with no submucosal invasion and a low MIB-1 labeling index 15 years after its detection using endoscopy. The endoscopic morphology changed from 0-IIa before H. pylori eradication to 0-IIa+IIc and then 0-I after H. pylori eradication. These findings suggest that the unaltered tumor size reflects low-grade malignancy and slow growth, and that the endoscopic morphology is influenced by H. pylori eradication.

Keywords

References

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