대한수의학회지 (Korean Journal of Veterinary Research)

  • 제61권1호
  • /
  • Pages.8.1-8.10
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  • 2021
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  • 2466-1384(pISSN)
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  • 2466-1392(eISSN)
대한수의학회 (The Korean Society of Veterinary Science)
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A retrospective study of 16 cats with intermediate- to high-grade alimentary lymphoma

  • Kwak, Dong-Hyuk (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chungnam National University) ;
  • Cho, Mun-Ju (Beaksan Feline Medical Center) ;
  • Park, Hyung-Jin (Sungsim Animal Medical Center) ;
  • Song, Kun-Ho (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chungnam National University) ;
  • Seo, Kyoung Won (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chungnam National University)
  • 투고 : 2021.01.15
  • 심사 : 2021.02.25
  • 발행 : 2021.03.31
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초록

The purpose of this retrospective study was to describe cases of feline intermediateto high-grade alimentary lymphoma regarding signalment, clinical presentation, laboratory findings, response to therapy (modified 25-week University of Wisconsin-Madison [UW-25] vs. COP [cyclophosphamide, vincristine, prednisone]), toxicosis, and outcomes and to identify prognostic factors. Sixteen cats were treated with chemotherapy protocols. Response rates and survival did not differ statistically between the two protocols. The progression-free interval (PFI) and median survival time (MST) in cats achieving a response to therapy were longer than in those with no response [NR] (complete remission [CR] vs. partial remission [PR] vs. NR; PFI, 124 vs. 49 vs. 12 days, p < 0.001; MST, 361 vs. 118 vs. 16 days, p < 0.001). Clinical stage was another prognostic factor for PFI and MST. The PFI and MST in cats in stage I were longer than in those in other stages (PFI, 107 days vs. 30 days; MST, 193 days vs. 54 days). Hematologic and gastrointestinal toxicosis was mostly low grade. In comparing the modified UW-25 protocol with the COP protocol, there was not much difference in the number of neutropenic episodes and grade levels.

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참고문헌

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