대한화장품학회지 (Journal of the Society of Cosmetic Scientists of Korea)

  • 제47권1호
  • /
  • Pages.49-56
  • /
  • 2021
  • /
  • 1226-2587(pISSN)
  • /
  • 2288-9507(eISSN)
대한화장품학회 (Society of Cosmetic Scientists of Korea)
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피부 지질 조성 모사 Ceramide 액정 에멀젼의 피부 장벽 강화 효과 확인에 관한 연구

Skin Barrier Function Enhancement Effect about Ceramide Liquid Crystal Emulsion: Similar Ratio of Skin Lipid Composition

  • 한지혜 (솔루스 첨단소재 주식회사) ;
  • 이주연 (솔루스 첨단소재 주식회사) ;
  • 이관형 (솔루스 첨단소재 주식회사) ;
  • 김희선 (솔루스 첨단소재 주식회사) ;
  • 박창열 (솔루스 첨단소재 주식회사) ;
  • 맹지혜 ((주)씨알에이코리아) ;
  • 소지민 ((주)씨알에이코리아) ;
  • 남개원 (서원대학교 바이오코스메틱학과) ;
  • 김상철 (솔루스 첨단소재 주식회사)
  • 투고 : 2020.11.18
  • 심사 : 2021.01.25
  • 발행 : 2021.03.30
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초록

본 연구에서는 ceramide, 당지질, cholesterol, 지방산을 이용하여 피부 지질 조성과 유사한 조성비를 갖는 액정 에멀젼을 제조하고 편광 현미경을 통해 제형 내 액정 입자를 확인하고, cryso-SEM을 이용하여 다층구조가 형성되었음을 확인하였다. 상기 제조된 샘플은 1 개월간 상온에 보관하여 액정구조가 지속적으로 유지되는 것을 현미경 관찰을 통해 확인하였다. 또한, 이렇게 제조된 액정 에멀젼을 포함하는 크림 조성물을 제조하고, 3 차원 인공피부를 활용한 ceramide 피부 투과 효율을 확인하였다. 해당 크림 조성물을 활용하여 임상시험을 진행하고 일반 에멀젼 대비 피험자의 피부 수분 보유량(skin hydration), 경피 수분 손실량(TEWL)을 측정함으로써 피부 장벽 개선에 대한 임상 실험 결과를 확인하였다.

In this study, a liquid crystal emulsion with a composition ratio similar to the skin lipid composition was manufactured using ceramide, glycolipids, cholesterol, and fatty acids, and a polarized microscope was used to identify liquid crystal particles in the formulation, and a cryso-SEM was used to confirm the formation of a multilayer structure. The above samples were stored at room temperature for one month and the liquid crystal structure was continuously maintained through microscopic observation. In addition, a cream composition containing liquid crystal emulsion was manufactured, and the efficiency of ceramide skin penetration was confirmed using three-dimensional artificial skin. Clinical trials were conducted using the cream composition and the results of clinical trials on skin barrier improvement were confirmed by measuring skin moisture retention (skin hydration) and transepidermal water loss (T EWL) of subjects compared to general emulsion.

키워드

참고문헌

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