Journal of Veterinary Science

The Korean Society of Veterinary Science (대한수의학회)
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Molecular evolutionary analysis reveals Arctic-like rabies viruses evolved and dispersed independently in North and South Asia

  • Yu, Xin (School of Life Sciences, Ludong University) ;
  • Zhu, Hongwei (School of Life Sciences, Ludong University) ;
  • Bo, Yongheng (Shandong Provincial Key Laboratory of Quality Safety Monitoring and Risk Assessment for Animal Products) ;
  • Li, Youzhi (Shandong Provincial Key Laboratory of Quality Safety Monitoring and Risk Assessment for Animal Products) ;
  • Zhang, Jianlong (School of Life Sciences, Ludong University) ;
  • Jiang, Linlin (School of Life Sciences, Ludong University) ;
  • Chen, Guozhong (School of Life Sciences, Ludong University) ;
  • Zhang, Xingxiao (School of Life Sciences, Ludong University) ;
  • Wen, Yongjun (College of Veterinary Medicine, Inner Mongolia Agricultural University)
  • Received : 2020.07.10
  • Accepted : 2020.10.28
  • Published : 2021.01.31
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Abstract

Background: Arctic-like (AL) lineages of rabies viruses (RABVs) remains endemic in some Arctic and Asia countries. However, their evolutionary dynamics are largely unappreciated. Objectives: We attempted to estimate the evolutionary history, geographic origin and spread of the Arctic-related RABVs. Methods: Full length or partial sequences of the N and G genes were used to infer the evolutionary aspects of AL RABVs by Bayesian evolutionary analysis. Results: The most recent common ancestor (tMRCA) of the current Arctic and AL RABVs emerged in the 1830s and evolved independently after diversification. Population demographic analysis indicated that the viruses experienced gradual growth followed by a sudden decrease in its population size from the mid-1980s to approximately 2000. Genetic flow patterns among the regions reveal a high geographic correlation in AL RABVs transmission. Discrete phylogeography suggests that the geographic origin of the AL RABVs was in east Russia in approximately the 1830s. The ancestral AL RABV then diversified and immigrated to the countries in Northeast Asia, while the viruses in South Asia were dispersed to the neighboring regions from India. The N and G genes of RABVs in both clades sustained high levels of purifying selection, and the positive selection sites were mainly found on the C-terminus of the G gene. Conclusions: The current AL RABVs circulating in South and North Asia evolved and dispersed independently.

Keywords

Acknowledgement

This work was supported by the National Key Research and Development Program of China (2016YFD0501001) and a grant from the Science and Technology Bureau of Yantai City, China (2019XDHZ094).

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