Journal of Pharmacopuncture (대한약침학회지)

KOREAN PHARMACOPUNCTURE INSTITUTE (대한약침학회)
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Biological and Therapeutic Effects of Troxerutin: Molecular Signaling Pathways Come into View

  • Ahmadi, Zahra (Department of Basic Science, Faculty of Veterinary Medicine, Islamic Azad Branch, University of Shushtar) ;
  • Mohammadinejad, Reza (Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences) ;
  • Roomiani, Sahar (Department of Basic Science, Faculty of Veterinary Medicine, Islamic Azad Branch, University of Shushtar) ;
  • Afshar, Elham Ghasemipour (Department of Microbiology, Faculty of Science, Islamic Azad University) ;
  • Ashrafizadeh, Milad (Department of Basic Science, Faculty of Veterinary Medicine, University of Tabriz)
  • Received : 2019.04.13
  • Accepted : 2021.03.04
  • Published : 2021.03.31
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Abstract

Flavonoids consist a wide range of naturally occurring compounds which are exclusively found in different fruits and vegetables. These medicinal herbs have a number of favourable biological and therapeutic activities such as antioxidant, neuroprotective, renoprotective, anti-inflammatory, anti-diabetic and anti-tumor. Troxerutin, also known as vitamin P4, is a naturally occurring flavonoid which is isolated from tea, coffee and cereal grains as well as vegetables. It has a variety of valuable pharmacological and therapeutic activities including antioxidant, anti-inflammatory, anti-diabetic and anti-tumor. These pharmacological impacts have been demonstrated in in vitro and in vivo studies. Also, clinical trials have revealed the efficacy of troxerutin for management of phlebocholosis and hemorrhoidal diseases. In the present review, we focus on the therapeutic effects and biological activities of troxerutin as well as its molecular signaling pathways.

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References

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