디지털융복합연구 (Journal of Digital Convergence)

  • 제19권3호
  • /
  • Pages.287-293
  • /
  • 2021
  • /
  • 2713-6434(pISSN)
  • /
  • 2713-6442(eISSN)
한국디지털정책학회 (The Society of Digital Policy and Management)
권호 표지
DOI QR코드

DOI QR Code

응급알레르기 상황에서 사용하기 쉬운 하이드로겔 제제의 제조 및 평가 과정

Manufacture and evaluation of hydrogel preparations that are easy to use in emergency allergy situations

  • 김철태 (건양대학교 응급구조학과) ;
  • 김훈 (건양대학교 제약생명공학과)
  • Kim, Chul-tae (Department of Emergency Medical Service, Konyang University) ;
  • Kim, Hoon (Department of Pharmaceutics & Biotechnology, Konyang University)
  • 투고 : 2020.01.20
  • 심사 : 2021.03.20
  • 발행 : 2021.03.28
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

본 연구는 콜린성 두드러기를 치료하기 위해 기존 제품으로는 정제를 사용하였다. 정제의 단점으로는 졸음유발 문제나 접근성 및 투여량 감소 문제가 있었으며 이를 해결하기 위해 세티리진 염산염을 함유한 Hydro-Gel을 제조하였다. 실험 방법은 점도, 겔화율, 팽윤도, 함량 평가, 투과성을 측정하였다. 연구에 따르면 세티리진 염산염을 함유한 하이드로 겔은 콜린성 두드러기가 유발되지 않아 발생 부위에 직접 적용할 수 있다. 또한 이 제제는 기존 정제의 부작용을 최소화하여 제품 생산이 가능하리라 생각한다. 이 제제에 스테로이드와 같은 다른 주요 성분을 첨가함으로써 구강으로 투여하는 방식보다 피부를 통해 투여할 수 있는 장점이 있어 활용도가 높을 것으로 사료된다. 또한 단독으로 사용해도 효과가 있다고 판단되어 의약품 제조 공정을 진행할 수 있을 것으로 기대된다.

Tablets were conventionally used to treat choline urticaria. Disadvantages of tablets included sleep inducing problems, accessibility and reduced dosage. To address this, hydrogel containing Cetirizine HCl was manufactured. The experimental method was to measure viscosity, gel fraction, degree of swelling, content evaluation, and permeability. Studies have shown that hydrogels containing Cetirizine HCl can be directly applied to occurrence area to improve Cholinergic urticaric with minimal side effects associated with the marketable tablets. This hydrogel includes other important substances including steroids which gives it an advantage when applied on the skin, improving its accessibility. In addition, it is expected that the drug manufacturing process will be able to proceed as this hydrogel is effective even when used alone.

키워드

참고문헌

  1. Y. Kawashima, T. Niwa, T. Handa, H. Takeuchi, T. Iwamoto & K Itoh. (1989) Preparation of controlled-release microspheres of ibuprofen with acrylic polymers by a novel quasi-emulsion solvent diffusion method. Journal of Pharmaceutical Sciences, 78(1), 68-72. DOI: 10.1002/jps.2600780118
  2. Y. C. Lei, C. C. Chan, P. Y. Wang, C. T. Lee & T. J. Cheng. (2004) Effects of Asian dust event articles on inflammation markers in peripheral blood and bronchoalveolar lavage in pulmonary hypertensive rats. Environ. Research, 95, 71-76. https://doi.org/10.1016/S0013-9351(03)00136-1
  3. P. K. Min. et al. (2001) Effect of Yellow sand on respiratory symptoms and diurnal variation of peak expiratory flow in patients with bronchial asthma. Journal of Asthma, Allergy and Clinical Immunology, 21, 1179-1186.
  4. H. J. Kwon, S. H. Cho, Y. Chun, F. Lagarde & G. Pershagen. (2002) Effects of Asian dust storm events on daily mortality in Seoul, Korea. Environemntal Research, 90(1), 1-5. DOI:10.1006/enrs.2002.4377
  5. M. Nakaya. et al. (2007) Prolonged allergen challenge in murine nasal allergic rhinitis: Nasal airway remodeling and adaptation of nasal airway responsiveness. The Laryngoscope, 17(5), 881-885.
  6. T. Y. Yoon, S. M. Kim, S. H. You & M. K. Kim. (2011) A Case of Exercise-induced Asthma Associated with Cholinergic Urticaria in a Patient with Allergic Rhinitis. The Korean Academy of Asthma, Allergy and Clinical Immunology, 31(2), 153-156.
  7. H. J. Jung, W. S Ko & H. J. Yoon. (2015) Korean Medicinal Approaches to Recent Study on Cholinergic Urticaria. The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, 28(4), 29-40. https://doi.org/10.6114/jkood.2015.28.4.029
  8. M. S. Caroline, F. Diana & H. P. David. (1993) A Reappraisal of its pharmacological Properties and Therapeutic Use in Selected Allergic Disorders. Drug Evaluation, 46(6), 1055-1080.
  9. N. M. Gray. (1997) Methods for treating urticaria using optically pure (+) cetirizine. United States Patent, 19, US005627183A.
  10. H. Y. Eom. et al. (2016) Rapid Chiral Separation of Racemic Cetirizine in Human Plasma using Supercritical Fluid Chromatography-Tandem Mass Spectrometry. Journal of Pharmaceutical and Biomedical Analysis, 117(5), 380-389. DOI:10.1016/j.jpba.2015.09.012
  11. J. P. Tillement, B. Testa & F. Bree. (2003) Compared pharmacological characteristics in humans of racemic cetirizine and levocetirizine, two histamine H1-receptor antagonists. Biochem. Pharmacology, 66(7), 1123-1126. https://doi.org/10.1016/S0006-2952(03)00558-6
  12. M. S. Lee, J. H. Lee, J. H. Jang, C. W. Nah & Y. I. Huh. (2019) Fabrication and Characterization of Modified Poly(2-hydroxyethyl methacrylate)(PHEMA) Hydrogels by Thermal/Photo Polymerization. Elastomers and Composites, 54(4), 359-367. https://doi.org/10.7473/EC.2019.54.4.359
  13. T. Evagenia, K. Olga & K. Costas. (2019) On the synthesis and characterization of biofunctional hyaluronic acid based injectable hydrogels for the repair of cartilage lesions. European Polymer Journal, 114(5), 47-56. https://doi.org/10.1016/j.eurpolymj.2019.02.024
  14. H. R. Yoon & J. H. Lee. (2012) Preparation of PNIPAM Hydrogel Containing Lipoic Acid. The Polymer Society of Korea, 36(4), 455-460. https://doi.org/10.7317/pk.2012.36.4.455
  15. A. Sannino, C. Demitri & M. Madaghiele. (2009) Biodegradable Cellulose-based Hydrogels Design and Applications. Materials, 2(2), 353-373. https://doi.org/10.3390/ma2020353
  16. I. Y. Kim. et al. (2007) Chitosan and its derivatives for tissue engineering applications. Biotechnology Advances, 26(1), 1-21. https://doi.org/10.1016/j.biotechadv.2007.07.009
  17. N.A. Peppasa, P. Buresa, W. Leobandunga & H. Ichikawa. (2000) Hydrogels in pharmaceutical formulations. European Journal of Pharmaceutics and Biopharmaceutics, 50(1), 27-46. https://doi.org/10.1016/S0939-6411(00)00090-4
  18. M. Y. Kim, B. K. Jung & J. H. Park. (2012) Hydrogel swelling as a trigger to release biodegradable polymer microneedles in skin. Biomaterials, 33(2), 668-679. https://doi.org/10.1016/j.biomaterials.2011.09.074
  19. S. C. Choi, W. C. Choi, S. W. Kim, S. Y. Lee, I. S. Noh & C. W. Kim. (2014) Purification and biocompatibility of fermented hyaluronic acid for its applications to biomaterials. Biomaterials Research, 18(6), 1-10. https://doi.org/10.1186/2055-7124-18-1