대한본초학회지 (The Korea Journal of Herbology)

  • 제36권2호
  • /
  • Pages.19-29
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  • 2021
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  • 1229-1765(pISSN)
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  • 2288-7199(eISSN)
대한본초학회 (The Korea Association of Herbology)
권호 표지
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추출 용매를 달리한 생강 추출물에 대한 생리활성의 비교 평가 연구

Comparative evaluation on biological activities of Ziingiber officinale Roscoe extracted from different solvents

  • 김소영 (대구한의대학교 한의과대학 본초약리학교실) ;
  • 최문열 (대구한의대학교 한의과대학 본초약리학교실) ;
  • 도은주 ((재)대구테크노파크 한방산업지원센터) ;
  • 김미려 (대구한의대학교 한의과대학 본초약리학교실)
  • Kim, So Young (Department of Herbal Pharmacology, College of Oriental Medicine, Daegu Haany University) ;
  • Choi, Moon-Yeol (Department of Herbal Pharmacology, College of Oriental Medicine, Daegu Haany University) ;
  • Do, Eun ju (Daegu Technopark Oriental Medicine Industry Support Center) ;
  • Kim, Mi Ryeo (Department of Herbal Pharmacology, College of Oriental Medicine, Daegu Haany University)
  • 투고 : 2021.02.10
  • 심사 : 2021.03.25
  • 발행 : 2021.03.30
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초록

Objective : This study was designed to investigate anti-oxidative, anti-aging and anti-inflammatory activities of Zingiber officinale Roscoe water (ZD) and 50% ethanol extracts (ZE). Method : The antioxidant capacity of ZD or ZE was analyzed by DPPH, ABTS scavenging activities and reducing power, respectively. The anti-aging efficacy was performed with tyrosinase and collagenase inhibition activities. The anti-inflammatory activities were confirmed through inhibition of nitric oxide production and TNF-�� expression in LPS-treated Raw 264.7 cells. Result : As a result of measuring DPPH and ABTS radical scavenging activities, both ZD and ZE extracts increased in concentration-dependent manners. The ABTS radical scavenging activities of water and 50% ethanol extract were similar to that of positive control at high concentration. On reducing power, both ZD and ZE showed higher activities than the positive control at high concentration. On inhibition activities of tyrosinase and collagenase both ZD and ZE showed the large inhibition rates at low concentration. Also, the inhibitory efficacy of ZD on NO and TNF-�� production was better than ZE in RAW 264.7 cells. Conclusion : These results suggest that ZD and ZE have anti-oxidative, anti-aging and anti-inflammatory effects in vitro. Especially, ZD was more effective than ZE. Thus, Ginger extract is considered to be highly useful as a cosmetic or food material with anti-oxidative, anti-aging (prevention of whitening and wrinkle) and anti-inflammatory effects. Also these effects may vary depending on the extraction solvent.

키워드

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