The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
권호 표지
DOI QR코드

DOI QR Code

Gossypii Semen oil alleviates memory dysfunction in scopolamine-treated mice

면화자 정유의 기억력 손상 완화 효과

  • Lee, Jihye (Division of Bio-technology and Convergence, College of Herbal Bio-Industry, Daegu Haany University) ;
  • Jung, Eun Mi (Division of Bio-technology and Convergence, College of Herbal Bio-Industry, Daegu Haany University) ;
  • Lee, Eunhong (Division of Bio-technology and Convergence, College of Herbal Bio-Industry, Daegu Haany University) ;
  • Jang, Gwi Yeong (Department of Herbal Crop Research, NIHHS, RDA) ;
  • Seo, Kyung Hye (Department of Herbal Crop Research, NIHHS, RDA) ;
  • Kim, Mi Ryeo (Department of Herbal Pharmacology, College of Korean Medicine, Daegu Haany University) ;
  • Jung, Ji Wook (Division of Bio-technology and Convergence, College of Herbal Bio-Industry, Daegu Haany University)
  • 이지혜 (대구한의대학교 바이오산업대학 바이오산업융합학부) ;
  • 정은미 (대구한의대학교 바이오산업대학 바이오산업융합학부) ;
  • 이은홍 (대구한의대학교 바이오산업대학 바이오산업융합학부) ;
  • 장귀영 (농촌진흥청 국립원예특작과학원 인삼특작부) ;
  • 서경혜 (농촌진흥청 국립원예특작과학원 인삼특작부) ;
  • 김미려 (대구한의대학교 한의과대학 본초약리학교실) ;
  • 정지욱 (대구한의대학교 바이오산업대학 바이오산업융합학부)
  • Received : 2021.02.01
  • Accepted : 2021.03.25
  • Published : 2021.03.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives : Gossypium arboreum (cotton) is traditionally used to treat various health disorders. However, anti-amnesic effect of G. arboreum has not been reported. The objective of this study was to investigate in-vivo the anti-amnesic effects along with in vitro antioxidant and acetylcholinesterase (AChE) inhibition potential in G. arboreum seed essential oil. Methods : The essential oil of G. arboreum obtained by solid phase microextraction (SPME) techniques were identified by gas chromatography-mass spectroscopy (GC-MS). 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assay were performed to determine the antioxidant activity at various concentrations (312.5, 625, 1250, 2500, 5000, 10000 ㎍/㎖. Y-maze, passive avoidance and Morris water maze tests were carried out to evaluate improved effect on scopolamine (1 mg/kg)-induced memory dysfunction at the dose level of 50, 100 and 200 mg/kg. Donepezil (5 mg/kg) was used as a positive drug control. We performed acetylcholinesterase (AChE) activity assay in ex vivo. Results : Five volatile compounds were identified in G. arboreum. The assays of DPPH and ABTS revealed that G. arboreum increased antioxidant activity in a dose-dependent manner. G. arboreum ameliorated the percent of spontaneous alternation in the Y-maze test, shortened step-through latency in the passive avoidance test, and increased swimming time in the target zone in the Morris water maze test. In addition, G. arboreum inhibited the AChE activity. Conclusions : Based on these findings, G. arboreum may aid in the prevention and treatment of learning and memory-deficit disorders through antioxidant and AChE inhibitory activities.

Keywords

References

  1. WHO 2019. Dementia; [accessed 2020 Sep 21]. Available from: https://www.who.int/news-room/fact-sheets/detail/dementia.
  2. Yiannopoulou KG, Papageorgiou SG. Current and Future Treatments in Alzheimer Disease: An Update. J Cent Nerv Syst Dis. 2020;12:1179573520907397.
  3. Volgin AD, Yakovlev OA, Demin KA, Alekseeva PA, Kyzar EJ, Collins C, et al. Understanding Central Nervous System Effects of Deliriant Hallucinogenic Drugs through Experimental Animal Models. ACS Chem Neurosci. 2019;10(1):143-54. https://doi.org/10.1021/acschemneuro.8b00433
  4. Brinza I, Abd-Alkhalek AM, El-Raey MA, Boiangiu RS, Eldahshan OA, Hritcu L. Ameliorative Effects of Rhoifolin in Scopolamine-Induced Amnesic Zebrafish (Danio rerio) Model. Antioxidants (Basel). 2020;9(7):580. https://doi.org/10.3390/antiox9070580
  5. Sathya S, Manogari BG, Thamaraiselvi K, Vaidevi S, Ruckmani K, Devi KP. Phytol loaded PLGA nanoparticles ameliorate scopolamine-induced cognitive dysfunction by attenuating cholinesterase activity, oxidative stress and apoptosis in Wistar rat. Nutr Neurosci. 2020:1-17.
  6. Liao J, Nai Y, Feng L, Chen Y, Li M, Xu H. Walnut Oil Prevents Scopolamine-Induced Memory Dysfunction in a Mouse Model. Molecules. 2020;25(7).
  7. Wang X, Zhang D, Song W, Cai CF, Zhou Z, Fu Q, et al. Neuroprotective effects of the aerial parts of Polygala tenuifolia Willd extract on scopolam-ineinduced learning and memory impairments in mice. Biomed Rep. 2020;13(5):37. https://doi.org/10.3892/br.2020.1304
  8. Capatina L, Todirascu-Ciornea E, Napoli EM, Ruberto G, Hritcu L, Dumitru G. Thymus vulgaris Essential Oil Protects Zebrafish against Cognitive Dysfunction by Regulating Cholinergic and Antioxidants Systems. Antioxidants (Basel). 2020;9(11):1083. https://doi.org/10.3390/antiox9111083
  9. Yadang FSA, Nguezeye Y, Kom CW, Betote PHD, Mamat A, Tchokouaha LRY, et al. Scopolam-ineInduced Memory Impairment in Mice: Neuroprotective Effects of Carissa edulis (Forssk.) Valh (Apocynaceae) Aqueous Extract. Int J Alzheimers Dis. 2020;2020:6372059.
  10. Kowalczyk J, Kurach L, Boguszewska-Czubara A, Skalicka-Wozniak K, Kruk-Slomka M, Kurzepa J, et al. Bergapten Improves Scopolamine-Induced Memory Impairment in Mice via Cholinergic and Antioxidative Mechanisms. Front Neurosci. 2020; 14:730. https://doi.org/10.3389/fnins.2020.00730
  11. Bio resource information service; Available from : https://bris.go.kr/portal/resource/book/selectResourceBookDtlInfo.do?lfrcMnno=KISTI0037X00369&gubun=2&siteGb=P&menuNo=200200
  12. National institute of crop science; Available from : https://www.nics.go.kr/bbs/view.do?m=100000153&bbsId=leaflet&bbsSn=9612
  13. National institute of biological resources; Available from : https://species.nibr.go.kr/home/mainHome.do?cont_link=009&subMenu=009002&contCd=009002&ktsn=120000061019
  14. Uzzaman R, Ghaffar M. Anti-diabetic and hypolipidemic effects of extract from the seed of Gossypium herbaceum L. in Alloxan-induced diabetic rabbits. Pak J Pharm Sci. 2017;30(1):75-86.
  15. Yoo C. Antioxidant and Anti-Diabetes Inhibitory Activity of Gossypium semen Exracts . Daegu: Kyungpook National University; 2013.
  16. Zhao Y, Dou J, Wu T, Aisa HA. Investigating the antioxidant and acetylcholinesterase inhibition activities of Gossypium herbaceam. Molecules. 2013;18(1):951-62. https://doi.org/10.3390/molecules18010951
  17. Liu Y, Aisa HA, Ji C, Yang N, Zhu H, Zuo P. Effects of Gossypium herbaceam extract administration on the learning and memory function in the naturally aged rats: neuronal niche improvement. J Alzheimers Dis. 2012;31(1):101-11. https://doi.org/10.3233/JAD-2012-112153
  18. Ellman GL, Courtney KD, Andres V, Jr., Feather-Stone RM. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol. 1961;7:88-95. https://doi.org/10.1016/0006-2952(61)90145-9
  19. Korea Institute of Oriental Medicine; 2015 [cited 21 Dec 2020]. Available from: https://mediclassics.kr/books/190/volume/43#content_1221
  20. Korea Institute of Oriental Medicine; 2015 [cited 21 Dec 2020]. Available from: https://mediclassics.kr/books/203/volume/5#content_43
  21. Lee DH. Analysis of Clinical Korean Medicine Studies on Dementia : Focused on Korean Literatures for 10 Years. Journal of Society of Preventive Korean Medicine. 2020;24(1):37-48.
  22. Panighel A, Flamini R. Applications of solid-phase microextraction and gas chromatography/mass spectrometry (SPME-GC/MS) in the study of grape and wine volatile compounds. Molecules. 2014;19(12):21291-309. https://doi.org/10.3390/molecules191221291
  23. Xue J, Li H, Liu F, Jiang W, Hou F. Vortex-assisted matrix solid-liquid dispersive microextraction for the analysis of triazole fungicides in cotton seed and honeysuckle by gas chromatography. Food Chem. 2016; 196: 867-76. https://doi.org/10.1016/j.foodchem.2015.09.093
  24. Kosma IS, Kontominas MG, Badeka AV. The Application of Chemometrics to Volatile Compound Analysis for the Recognition of Specific Markers for Cultivar Differentiation of Greek Virgin Olive Oil Samples. Foods. 2020;9(11):1672. https://doi.org/10.3390/foods9111672
  25. Ramalho TR, Oliveira MT, Lima AL, Bezerra-Santos CR, Piuvezam MR. Gamma-Terpinene Modulates Acute Inflammatory Response in Mice. Planta Med. 2015;81(14):1248-54. https://doi.org/10.1055/s-0035-1546169
  26. Guo Y, Baschieri A, Amorati R, Valgimigli L. Synergic antioxidant activity of gamma-terpinene with phenols and polyphenols enabled by hydroperoxyl radicals. Food Chem. 2020: 128468. https://doi.org/10.1016/j.foodchem.2020.128468
  27. Giweli A, Dzamic AM, Sokovic M, Ristic MS, Marin PD. Antimicrobial and antioxidant activities of essential oils of Satureja thymbra growing wild in Libya. Molecules. 2012;17(5):4836-50. https://doi.org/10.3390/molecules17054836
  28. Gao L, Chen W, Xu X, Zhang J, Singh TK, Liu S, et al. Engineering Trienoic Fatty Acids into Cottonseed Oil Improves Low-Temperature Seed Germination, Plant Photosynthesis and Cotton Fiber Quality. Plant Cell Physiol. 2020; 61(7): 1335-47. https://doi.org/10.1093/pcp/pcaa062
  29. Ilyasov IR, Beloborodov VL, Selivanova IA, Terekhov RP. ABTS/PP Decolorization Assay of Antioxidant Capacity Reaction Pathways. Int J Mol Sci. 2020; 21(3):1131. https://doi.org/10.3390/ijms21031131
  30. Kang TK. Antioxidant Activities of Ethanolic Extracts from Gossypium arboreum L. J Invest Cosmetol. 2019;15(2):137-46. https://doi.org/10.15810/JIC.2019.15.2.003
  31. Kim JY, Lee HY, Jo WS, Park SC. Comparison of composition and antioxidant activity of Poria cocos Wolf cultivated in a mortuary and cemetery. Journal of mushrooms . 2018;16:111-7.
  32. Kim MS, Lee JN, Seong HJ, Kim DH, Sohn HY. Changes in the in vitro Antioxidant and Antithrombosis Activities of Salicornia europaea According to Harvest Time. Journal of Life Science. 2016;26:1033-40. https://doi.org/10.5352/JLS.2016.26.9.1033
  33. Choi MH, Kang JR, Sim HJ, Kang MJ, Seo WT, Bae WY, Shin JH. Physicochemical characteristics and antioxidant activity of Sumaeyaksuk depending on harvest times and processing methods. Korean journal of food preservation. 2015;22:399-407. https://doi.org/10.11002/KJFP.2015.22.3.399
  34. Kim K, Bu Y, Jeong S, Lim J, Kwon Y, Cha DS, et al. Memory-enhancing effect of a supercritical carbon dioxide fluid extract of the needles of Abies koreana on scopolamine-induced amnesia in mice. Biosci Biotechnol Biochem. 2006;70(8):1821-6. https://doi.org/10.1271/bbb.50608
  35. Perry NS, Houghton PJ, Theobald A, Jenner P, Perry EK. In-vitro inhibition of human erythrocyte acetylcholinesterase by salvia lavandulaefolia essential oil and constituent terpenes. J Pharm Pharmacol. 2000;52(7):895-902. https://doi.org/10.1211/0022357001774598
  36. Capatina L, Boiangiu RS, Dumitru G, Napoli EM, Ruberto G, Hritcu L, et al. Rosmarinus officinalis Essential Oil Improves Scopolamine-Induced Neurobehavioral Changes via Restoration of Cholinergic Function and Brain Antioxidant Status in Zebrafish (Danio rerio). Antioxidants (Basel). 2020;9(1):62. https://doi.org/10.3390/antiox9010062
  37. Manganiello-Terra FA, Correa-Netto NF, Masukawa MY, Ruzzi A, Linardi A, Santos-Junior JG. Inhaled Lavandula angustifolia essential oil enhances extinction learning and inhibits memory updating in mice submitted to the contextual fear conditioning. J Ethnopharmacol. 2020;260:113048. https://doi.org/10.1016/j.jep.2020.113048
  38. Zhang Y, Long Y, Yu S, Li D, Yang M, Guan Y, et al. Natural volatile oils derived from herbal medicines: A promising therapy way for treating depressive disorder. Pharmacol Res. 2020;164:105376.
  39. Zhang N, Yao L. Anxiolytic Effect of Essential Oils and Their Constituents: A Review. J Agric Food Chem. 2019;67(50):13790-808. https://doi.org/10.1021/acs.jafc.9b00433
  40. Proctor GR, Harvey AL. Synthesis of tacrine analogues and their structure-activity relationships. Curr Med Chem. 2000;7(3):295-302. https://doi.org/10.2174/0929867003375218