대한한방소아과학회지 (The Journal of Pediatrics of Korean Medicine)

  • 제35권1호
  • /
  • Pages.104-121
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  • 2021
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  • 1226-8038(pISSN)
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  • 2287-9463(eISSN)
대한한방소아과학회 (The Association of Korean Oriental Pediatrics)
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소아 기능성 복통의 한약치료에 대한 임상연구 동향 - 중의학 논문을 중심으로 -

Review of Clinical Researches for Herbal Medicine Treatment on Functional Abdominal Pain in Children.

  • 박세미 (동의대학교 한의과대학 한방소아과학교실) ;
  • 유선애 (동의대학교 한의과대학 한방소아과학교실)
  • Park, Se Mi (Department of Pediatrics, College of Korean Medicine, DongEui University) ;
  • Yu, Sun Ae (Department of Pediatrics, College of Korean Medicine, DongEui University)
  • 투고 : 2021.01.15
  • 심사 : 2021.02.22
  • 발행 : 2021.02.28
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초록

Objectives The purpose of this study is to evaluate the efficacy and safety of herbal medication for the treatment of functional abdominal pain in children by analyzing randomized controlled trials conducted in China. Methods Literatures from China National Knowledge Infrastructure published up to 23 November, 2020 were searched. Then they were collected and analyzed by their publication year, demographic information, treatment methods used, duration of illnesses, duration of treatments, follow-up periods, outcome measurement and adverse events. Results A total of 27 studies were selected for the analysis. In all studies, the total efficacy of the herbal medicine treatment group was reported to be higher than that of the control group. The most frequently used medical herb was Root of Glycyrrhiza uralensis Fischer (甘草). The most frequently used classes of herbal medications are Qi regulating medicine (理氣藥), Qi tonics (補氣藥), Aromatic wet medicine (芳香化濕藥), and Digestant (消食藥). The adverse events rate for the herbal medicine treatment group were significantly lower than those in the Western medicine treatment group. Conclusions This study showed that herbal medicine treatment can be effective and safe option for treating pediatric functional abdominal pain. However, additional well-designed clinical studies are needed to solidify the findings.

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참고문헌

  1. Shin JY. Pharmacological Treatment for Functional Abdominal Pain in Children. Korean J Pediatr Gastroenterol Nutr 2009;12(1):103-10.
  2. Department of Pediatrics, National Oriental Medicine College. Pediatrics of Korean Medicine. Seoul: Uiseongdang Publishing Co. 2020:346-59.
  3. Uhm JH, M.D. Characteristics of functional gastrointestinal disorders in children with chronic abdominal pain. Korean J Pediatr. 2007;50:655-9. https://doi.org/10.3345/kjp.2007.50.7.655
  4. Tchah H. Recurrent Abdominal Pain. Journal of the Korean Pediatric Society. 2003;46(5):434-9.
  5. Lee DH, Jo JG, Jeong GM. Literature Review on Children's Abdominal Pain. J Korean Orient Pediatr. 1987;2(1):55-61.
  6. Lee SJ, Park EJ, Kim DG, Jeong GM. A Literature Review on the Etiology and Pathology of Children's Abdominal Pain. J Korean Orient Pediatr. 1991;5(1):43-54.
  7. Shin DG, Lee JY, Jeong GM. Literature Review on Children's Abdominal Pain. J Korean Orient Pediatr. 1995;9(1):15-24.
  8. Lee SH, Chang GT, Kim JH. A study on the correlation of Chiljung with chronic recurrent abdominal pain in children. J Korean Orient Pediatr. 2004;18(1):139-52.
  9. Kim SH, Lee SY. An Study on Abdominal Pain in Childhood according to Its Symptoms. J Korean Orient Pediatr 2001;15(2):53-68.
  10. Kim SH, Park SW, Lee SY. A Study on Clinical Classification and Characteristic of Children with Recurrent Abdominal Pain. J Korean Orient Pediatr. 2002;16(2):1-22.
  11. Jeong MJ, Lyu SA, Lee SY. Effects of the HyangsayukgunjatangGamibang on Children with Abdominal Pain. J Korean Orient Pediatr. 2007;21(3):57-69.
  12. Zhang Q. Muxiang Shunqi Powder in Treating 48 Children with Functional Abdominal Pain. China Medical Herald. 2006(30):89.
  13. Chen. Self-made Rougan Lipi Decoction to Treat 60 Children with Functional Abdominal Pain. Clinical Journal of Traditional Chinese Medicine. 2006(03):285.
  14. Dang H, Niu M. Treating 30 Cases of Children's Functional Abdominal Pain with Yunpi Liqi Decoction. Shaanxi Journal of Traditional Chinese Medicine. 2010(07): 835-6.
  15. Qiao. Clinical Observation on Treatment of 38 Cases of Children's Functional Abdominal Pain with Xiangsha Liujunzi Decoction. Journal of Pediatrics of Traditional Chinese Medicine. 2010;6(01):40-1.
  16. Ying J, Li W, Ji Y. Treatment of 32 Cases of Functional Abdominal Pain with Mo Decoction and Peifeikang. Journal of Integrated Traditional Chinese and Western Medicine. 2010;20(12):786-92.
  17. Liu S, Zhou Y. Observation on Therapeutic Effect of 42 Cases of Children with Functional Abdominal Pain Treated by Chinese Medicine. Journal of Emergency in Traditional Chinese Medicine. 2012;21(08):1342.
  18. Shuai F. Clinical Observation on Wenpi Jianwei Granule Treating Children with Functional Abdominal Pain. Journal of Liaoning University of Traditional Chinese Medicine. 2012;14(05):178-9.
  19. Chen YH, Ling K, GAO XL, WANG X, MA JH. Clinical Observation on efficacy of Wenzhong analgesic prescription in treating Functional Abdominal Pain in Children. Chinese Journal of Experimental Traditional Medical Formulae. 2013;19(14):317-9.
  20. Chen X, Zeng X. Treatment of 52 cases of children with functional abdominal pain with Wenzhong Zhitong Decoction. Chinese Medicine Modern Distance Education of China. 2014;12(24):49-50.
  21. Han J, Ji W. Clinical Observation of Wumei Tiaozhong Granules in Treating Children's Functional Recurrent Abdominal Pain. Journal of Sichuan of Traditional Chinese Medicine. 2014(01):108-9.
  22. Yao WG, Chen Q, Jiang C. Children with Functional Abdominal Pain Treated with Shaoyao Gancao Decoction. Journal of Zhejiang Chinese Medical University. 2015;39(06):470-2.
  23. Liu H, Liu Z, Li H, Song M. Observation on the curative effect of self-made Yuanhu Shixiao San on children with functional abdominal pain. Beijing Journal of Traditional Chinese Medicine. 2015;34(06):477-9.
  24. Zhong W, Huang Y. Wu Mei Wan and Western medicine treatment of children with functional abdominal pain Clinical comparative study. Global Traditional Chinese Medicine. 2015;8(S2):151.
  25. Ma BS, Han HQ. Effect observation of infant fuxiening effervescent granules in the treatment of children with functional abdominal pain. Chinese Journal of Clinical Rational Drug Use. 2016;9(28):20-1
  26. Dong L. Observation on the effect of Wenzhong Decoction on 38 cases of children with functional abdominal pain. Hunan Journal of Traditional Chinese Medicine. 2017;33(10):79-80.
  27. Li F. Treatment of 56 cases of children with functional abdominal pain by Banxia Xiexin Decoction. Zhejiang Journal of Traditional Chinese Medicine. 2017;52(03):204.
  28. Liang J. The Research of Clinical Effect of Relieving Liver-qi Depression and Dissipating Dampness on Treatmenting of Functional Abdominal Pain in Children(FAP) Which Is Caused by Stagnation of Liver-qi and Dampness-heat [Master's Theses]: Guangzhou University of Chinese Medicine; 2018.
  29. Xi YY. The Clinical Study of the Application of Taking Spleen-Transporting and Tension-Relaxing Decoction in the Treatment of the Functional Abdominal Pain in Children [Master's Theses]: Shanxi University of Traditional Chinese Medicine; 2018.
  30. Zhang Z. Clinical Observation on Treatment of 75 Cases of Children with Functional Abdominal Pain with Shaoyao Gancao Decoction. Hunan Journal of Traditional Chinese Medicine. 2018;34(10):69-70.
  31. Lu X. Clinical Study of Agastache Mume Decoction in Treating Cold Heatjumble of Children with Functional Abdominal Pain. [Master's Theses]: Shanxi University of Traditional Chinese Medicine; 2018
  32. Meng MQ. The clinical efficacy of Tongshaotongan Decoction in the treatment of recurrent abdominal pain in children [Master's Theses]: Zhejiang University of Traditional Chinese Medicine; 2019.
  33. Huang LY. Therapeutic effect of Wenzhong Zhitong Recipe on children with functional abdominal pain. Journal of Qiqihar Medical University. 2019;40(03):340-1.
  34. Huang WJ. Clinical Study on Huaji Granules Combined with Compound Pepsin Powder for Functional Abdominal Pain in Children. Journal of New Chinese Medicine. 2019;51(09):181-3.
  35. Li YY. Clinical Observation of Shanzhu Xiaoji Zhitong Decoction in the Treatment of 60 Cases of Pediatric Functional Abdominal Pain and Milk Product Stasis Syndrome [Master's Theses]: Changchun University of Chinese Medicine; 2020.
  36. Li J. Clinical observation on the treatment of 37 children with functional abdominal pain with Shaoyao Gancao Decoction. Chinese Journal of Ethnomedicine and Ethnopharmacy. 2020;29(05):62-4.
  37. Zhang XL, Li MG, Wang QQ, Mu JX, Wang XL. Clinical observation on Sanxian Xiaoji Pingtong Decoction in the treatment of functional abdominal pain with stagnation of milk and food. Modern Journal of Integrated Traditional Chinese and Western Medicine. 2020;29(32): 3560-3.
  38. Zhang XY, Fu H. Observation on the curative effect of Liqi Zhitong Recipe in the treatment of children with functional abdominal pain. Journal of Practical Traditional Chinese Medicine. 2020;36(10):1272-3.
  39. National Oriental Medicine College Collaborative Textbook Compilation Committee. Herbalogy. Seoul: Young Lim Publishing Co. 2011:10-8.
  40. Hong CE, Pediatrics, Seoul: Mirae N co. 2016:540-3.
  41. Taminiau J, Benninga M. Pediatric clinical research will benefit from Rome III. J Pediatr Gastroenterol Nutr 2005;41 Suppl 1:30-1.
  42. Hyams JS, Burke G, Davis PM, Rzepski B, Andrulonis PA. Abdominal pain and irritable bowel syndrome in adolescents: a community-based study. J Pediatr 1996;129:220-6. https://doi.org/10.1016/S0022-3476(96)70246-9
  43. Drossman DA. The functional gastrointestinal disorder-sand the Rome III process. Gastroenterology 2006;130:1377-90. https://doi.org/10.1053/j.gastro.2006.03.008
  44. Rasquin A, Hyman PE, Cucchiara S, Fleisher DR, Hyams JS, Milla PJ, et al. Childhood functional gastrointestinal disorders. Gut 1999;45(2):60-8
  45. Rasquin A, Di Lorenzo C, Forbes D, Guiraldes E, Hyams JS, Staiano A, et al. Childhood functional gastrointestinal disorders: child/adolescent. Gastroenterology 2006;130:1527-37. https://doi.org/10.1053/j.gastro.2005.08.063
  46. Drossman DA, Hasler WL. Rome IV-functional GI disorders: disorders of gut-brain interaction. Gastroenterology 2016;150:1257-61. https://doi.org/10.1053/j.gastro.2016.03.035
  47. Bufler P, Gross M, Uhlig HH. Recurrent abdominal pain in childhood. Dtsch Arztebl Int 2011;108:295-304.
  48. Di LC, Colletti RB, Lehmann HP, Boyle JT, Gerson WT, Hyams JS, et al. Chronic Abdominal Pain in Children : A Clinical Report of the American Academy of Pediatrics and the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition : American Academy of Pediatrics Subcommittee on Chronic Abdominal Pain and NASPGHAN Committee on Abdominal Pain. J Pediatr Gastroenterol Nutr 2005;40:245-48. https://doi.org/10.1097/01.MPG.0000155367.44628.21
  49. Ryu HS, Choi SC. Clinical Approach to Abdominal Pain as Functional Origin. The Korean Journal of Gastroenterology2018;71(2):89-93. https://doi.org/10.4166/kjg.2018.71.2.89
  50. Poupko, Jay M et al. The pharmacological properties of anisodamine. Journal of applied toxicology : 2007;27(2):116-21. https://doi.org/10.1002/jat.1154