Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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Effect of Jesaeng-sinkihwan on Renal Dysfunction in Ischemia/Reperfusion-Induced Acute Renal Failure Mouse

제생신기환이 허혈-재관류로 유발된 급성 신부전 마우스에 미치는 효과

  • Han, Byung Hyuk (College of Oriental Medicine and Professional Graduate School of Oriental Medicine) ;
  • Lee, Hyeon Kyoung (College of Oriental Medicine and Professional Graduate School of Oriental Medicine) ;
  • Jang, Se Hoon (College of Oriental Medicine and Professional Graduate School of Oriental Medicine) ;
  • Tai, Ai Lin (College of Oriental Medicine and Professional Graduate School of Oriental Medicine) ;
  • Yoon, Jung Joo (College of Oriental Medicine and Professional Graduate School of Oriental Medicine) ;
  • Kim, Hye Yoom (College of Oriental Medicine and Professional Graduate School of Oriental Medicine) ;
  • Lee, Yun Jung (College of Oriental Medicine and Professional Graduate School of Oriental Medicine) ;
  • Lee, Ho Sub (College of Oriental Medicine and Professional Graduate School of Oriental Medicine) ;
  • Kang, Dae Gill (College of Oriental Medicine and Professional Graduate School of Oriental Medicine)
  • 한병혁 (원광대학교 한의과대학 및 한의전문대학원) ;
  • 이현경 (원광대학교 한의과대학 및 한의전문대학원) ;
  • 장세훈 (원광대학교 한의과대학 및 한의전문대학원) ;
  • 태애림 (원광대학교 한의과대학 및 한의전문대학원) ;
  • 윤정주 (원광대학교 한의과대학 및 한의전문대학원) ;
  • 김혜윰 (원광대학교 한의과대학 및 한의전문대학원) ;
  • 이윤정 (원광대학교 한의과대학 및 한의전문대학원) ;
  • 이호섭 (원광대학교 한의과대학 및 한의전문대학원) ;
  • 강대길 (원광대학교 한의과대학 및 한의전문대학원)
  • Received : 2021.01.09
  • Accepted : 2021.02.18
  • Published : 2021.02.28
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Abstract

Renal ischemia-reperfusion injury(IRI), an important cause of acute renal failure (ARF), cause increased renal tubular injury. Jesaeng-sinkihwan (JSH) was recorded in a traditional Chines medical book named "Bangyakhappyeon (方藥合編)". JSH has been used for treatment of diabetes and glomerulonephritis with patients. Here we investigate the effects of Jesaeng-sinkihwan (JSH) in a mouse model of ischemic acute kidney injury. The animals model were divided into four groups at the age of 8 weeks; sham group: C57BL6 male mice (n=9), I/R group: C57BL6 male mice with I/R surgery (n=9), JSH Low group: C57BL6 male mice with surgery + JSH 100 mg/kg/day (n=9) and JSH High group: C57BL6 male mice with surgery + JSH 300 mg/kg/day (n=9). Ischemia was induced by clamping the both renal arteries during 25 min, and reperfusion was followed. Mouse were orally given with JSH (100 and 300 mg/kg/day during 3 days after surgery. Treatment with JSH significantly ameliorates creatinine clearance(Ccr), Creatinine (Cr) and blood urea nitrogen(BUN) in obtained plasma. . Treatment with JSH reduced kidney inflammation markers such as Neutrophil Gelatinase Associated Lipocalin (NGAL) and kidney injury molecule-1 (KIM-1). JSH also reduced the periodic acid schiff (PAS) staining intensity and picro sirius red staining intensity in kidney of I/R group. These findings suggest that JSH ameliorates tubular injury including renal dysfunction in I/R induced ARF mouse.

Keywords

References

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