대한한의학방제학회지 (Herbal Formula Science)

  • 제29권1호
  • /
  • Pages.19-31
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  • 2021
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  • 1229-1218(pISSN)
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  • 2288-5641(eISSN)
대한한의학방제학회 (The Korean Medicine Society for the Herbal Formula Study)
권호 표지
DOI QR코드

DOI QR Code

단삼(丹參)을 뇌졸중 동물모델에 적용하기 위한 기초적인 네트워크 약리학 분석

Basic network pharmacological analysis of Salvia miltiorrhiza root for further application to an animal stroke model

  • 최명진 (부산대학교 한의학전문대학원) ;
  • 양원진 (부산대학교 한의학전문대학원) ;
  • 이병호 (인주한방병원) ;
  • 조수인 (부산대학교 한의학전문대학원)
  • Choi, Myeongjin (School of Korean Medicine, Pusan National University) ;
  • Yang, Wonjin (School of Korean Medicine, Pusan National University) ;
  • Lee, Byoungho (Inju Hospital of Korean Medicine) ;
  • Cho, Suin (School of Korean Medicine, Pusan National University)
  • 투고 : 2020.12.08
  • 심사 : 2021.02.15
  • 발행 : 2021.02.28
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초록

Objectives : The root of Salvia miltiorrhiza, known as 'Dansam (DS, 丹參)', is used for and treating cardiovascular diseases based on its efficacy of promoting blood circulation and breaking through a blood stasis. In this study, we would like to see if DS could be effectively used for stroke from the perspective of network pharmacology. Methods : The analysis was conducted using Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) database to derive the main active compounds of DS and identify the mechanism of each compound acting on the human body. The networks between compounds, target protein and disease were expressed through Cytoscape. Protein-protein interaction (PPI) analysis was performed using STRING database. Results : Fifty two active compounds of DS were identified by screening the ingredients of DS through TCMSP. Based on the networks of these compounds with target protein and disease, it can be said that DS might be effective for preventing and treating stroke. PPI result showed that adrenergic receptor has many interactions among proteins, indicating its significance in stroke pathway. Conclusion : In this study, we derived target proteins and target diseases of DS that could be used in study of stroke. However, since it is uncertain if these targets can be controlled by DS extracts or not, we would like to confirm the results with further animal experiments.

키워드

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