Advances in nano research

  • 제10권1호
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  • Pages.59-69
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  • 2021
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  • 2287-237X(pISSN)
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  • 2287-2388(eISSN)
테크노프레스 (Techno-Press)
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DOI QR코드

DOI QR Code

Using Taguchi design of experiments for the optimization of electrospun thermoplastic polyurethane scaffolds

  • Nezadi, Maryam (Department of Biomedical Engineering, Amirkabir University of Technology (Tehran Polytechnic)) ;
  • Keshvari, Hamid (Department of Biomedical Engineering, Amirkabir University of Technology (Tehran Polytechnic)) ;
  • Yousefzadeh, Maryam (Department of Textile Engineering, Amirkabir University of Technology (Tehran Polytechnic))
  • 투고 : 2019.11.01
  • 심사 : 2020.11.09
  • 발행 : 2021.01.25
⟨ 이전 논문 다음 논문 ⟩

초록

Electrospinning is a cost-effective and versatile method for producing submicron fibers. Although this method is relatively simple, at the theoretical level the interactions between process parameters and their influence on the fiber morphology are not yet fully understood. In this paper, the aim was finding optimal electrospinning parameters in order to obtain the smallest fiber diameter by using Taguchi's methodology. The nanofibers produced by electrospinning a solution of Thermoplastic Polyurethane (TPU) in Dimethylformamide (DMF). Polymer concentration and process parameters were considered as the effective factors. Taguchi's L9 orthogonal design (4 parameters, 3 levels) was applied to the experiential design. Optimal electrospinning conditions were determined using the signal-to-noise (S/N) ratio with Minitab 17 software. The morphology of the nanofibers was studied by a Scanning Electron Microscope (SEM). Thereafter, a tensile tester machine was used to assess mechanical properties of nanofibrous scaffolds. The analysis of DoE experiments showed that TPU concentration was the most significant parameter. An optimum combination to reach smallest diameters was yielded at 12 wt% polymer concentration, 16 kV of the supply voltage, 0.1 ml/h feed rate and 15 cm tip-to-distance. An empirical model was extracted and verified using confirmation test. The average diameter of nanofibers at the optimum conditions was in the range of 242.10 to 257.92 nm at a confidence level 95% which was in close agreement with the predicted value by the Taguchi technique. Also, the mechanical properties increased with decreasing fibers diameter. This study demonstrated Taguchi method was successfully applied to the optimization of electrospinning conditions for TPU nanofibers and the presented scaffold can mimic the structure of Extracellular Matrix (ECM).

키워드

과제정보

The authors acknowledge the Nanofibers and Electrospinning Lab and Amirkabir University of Technology for the support to do this work.

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