한국미생물·생명공학회지 (Microbiology and Biotechnology Letters)

  • 제49권4호
  • /
  • Pages.467-477
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  • 2021
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  • 1598-642X(pISSN)
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  • 2234-7305(eISSN)
한국미생물·생명공학회 (The Korean Society for Microbiology and Biotechnology)
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Exploring Staphylococcus aureus Virulence Factors; Special Emphasis on Staphyloxanthin

  • Yehia, Fatma Al-zahraa A. (Department of Microbiology and Immunology, Faculty of Pharmacy, Zagazig University) ;
  • Yousef, Nehal (Department of Microbiology and Immunology, Faculty of Pharmacy, Zagazig University) ;
  • Askoura, Momen (Department of Microbiology and Immunology, Faculty of Pharmacy, Zagazig University)
  • 투고 : 2021.07.19
  • 심사 : 2021.11.20
  • 발행 : 2021.12.28
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초록

Staphylococcus aureus is a well-known pathogen that can cause diseases in humans. It can cause both mild superficial skin infections and serious deep tissue infections, including pneumonia, osteomyelitis, and infective endocarditis. To establish host infection, S. aureus manages a complex regulatory network to control virulence factor production in both temporal and host locations. Among these virulence factors, staphyloxanthin, a carotenoid pigment, has been shown to play a leading role in S. aureus pathogenesis. In addition, staphyloxanthin provides integrity to the bacterial cell membrane and limits host oxidative defense mechanisms. The overwhelming rise of Staphylococcus resistance to routinely used antibiotics has necessitated the development of novel anti-virulence agents to overcome this resistance. This review presents an overview of the chief virulence determinants in S. aureus. More attention will be paid to staphyloxanthin, which could be a possible target for anti-virulence agents.

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