Women's Health Nursing (여성건강간호학회지)

Korean Society of Women Health Nursing (한국여성건강간호학회)
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Association between breastfeeding and breast, thyroid, and cervical cancer among Korean adult women based on the Korean Genome and Epidemiology Study: a cohort study

  • Jin, Eunju (Department of Nursing, Graduate School, Kangwon National University) ;
  • Kang, Hyunju (College of Nursing, Kangwon National University) ;
  • Son, Mia (College of Medicine, Kangwon National University)
  • Received : 2021.08.13
  • Accepted : 2021.11.29
  • Published : 2021.12.31
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Abstract

Purpose: The purpose of this study was to explore the association between breastfeeding and the prevalence of breast, thyroid, and cervical cancer among Korean adult women. Methods: The study was a secondary analysis of data from the Korea Genome and Epidemiology Study. The final samples were 113,944 Korean women among 173,205 urban-based cohort participants collected between 2004 and 2013 for adults aged forty and over. To determine the association between female cancers and breastfeeding experience, the number of childbirth, and total breastfeeding duration, logistic regression analysis was done. The demographic characteristics, health behavior, and female history were adjusted. Results: The prevalence of breast cancer was 1.37 times higher in the non-breastfeeding group than in the breastfeeding group. Compared to having breastfed for more than 36 months, the prevalence of thyroid cancer was 1.68 times higher at breastfeeding for 13 to 36 months, 1.67 times higher at breastfeeding for 6 to 12 months, and 2.06 times higher at breastfeeding less than 6 months. Also, the prevalence of cervical cancer was 1.54 times higher at breastfeeding for 13 to 36 months, compared to breastfeeding for more than 36 months. Conclusion: The study found that breastfeeding experience and a longer breastfeeding duration are associated with reduced risk of breast, thyroid, and cervical cancer in Korean women. It can be used as a basis for encouraging breastfeeding, and suggests further research on modifiable factors that reduce cancer risks.

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References

  1. National Cancer Center. National cancer statistics in Korea 2018 [Internet]. Goyang, Korea: Author; 2020 [cited 2021 May 9]. Available from: https://www.ncc.re.kr/cancerStatsView.ncc?bbsnum=558&searchKey=total&searchValue=&pageNum=1
  2. Ministry of Health and Welfare. Press release [Internet]. Sejong, Korea: Author; 2020 [cited 2021 May 9]. Available from: https://www.mohw.go.kr/react/al/sal0301vw.jsp?PAR_MENU_ID=04&MENU_ID=0403&page=2&CONT_SEQ=362695
  3. Kim HI, Lim H, Moon A. Sex differences in cancer: epidemiology, genetics and therapy. Biomol Ther (Seoul). 2018;26(4):335-342. https://doi.org/10.4062/biomolther.2018.103
  4. Park B, Choi JY, Sung HK, Ahn C, Hwang Y, Jang J, et al. Attribution to heterogeneous risk factors for breast cancer subtypes based on hormone receptor and human epidermal growth factor 2 receptor expression in Korea. Medicine (Baltimore). 2016;95(14):e3063. https://doi.org/10.1097/MD.0000000000003063
  5. Park SK. Epidemiological characteristics of breast cancer in Koreans. J Korean Med Assoc. 2019;62(8):424-436. https://doi.org/10.5124/jkma.2019.62.8.424
  6. Clinton SK, Giovannucci EL, Hursting SD. The World Cancer Research Fund/American Institute for Cancer Research Third Expert Report on Diet, Nutrition, Physical Activity, and Cancer: impact and future directions. J Nutr. 2020;150(4):663-671. https://doi.org/10.1093/jn/nxz268
  7. National Cancer Information Center. Cancer I want to know [Internet]. Goyang, Korea: Author; 2021 [cited 2021 May 2]. Available from: https://www.cancer.go.kr/lay1/program/S1T211C223/cancer/view.do?cancer_seq=4877&menu_seq=4884
  8. Cao Y, Wang Z, Gu J, Hu F, Qi Y, Yin Q, et al. Reproductive factors but not hormonal factors associated with thyroid cancer risk: a systematic review and meta-analysis. Biomed Res Int. 2015;2015:103515. https://doi.org/10.1155/2015/103515
  9. Korea Research Foundation for Gynecologic Cancer. Everything about gynecologic cancer [Internet]. Seoul: Author; 2021 [cited 2021 May 10]. Available form: http://www.womans-wells.or.kr/info/wc_info.php
  10. Reis N, Beji NK, Kilic D. Risk factors for cervical cancer: results from a hospital-based case-control study. Int J Hematol Oncol. 2011;21(3):153-159. https://doi.org/10.4999/uhod.09061
  11. World Health Organization. Health topics: Breastfeeding [Internet]. Geneva: Author; 2021 [cited 2021 May 10]. Available form: https://www.who.int/health-topics/breastfeeding
  12. Ahn HS, Shin HY. Hong Chang Ui Pediatrics, volume 1. 11st ed. Seoul: Mirae N; 2018. p. 78-79.
  13. Del Ciampo LA, Del Ciampo IRL. Breastfeeding and the benefits of lactation for women's health. Rev Bras Ginecol Obstet. 2018;40(6):354-359. https://doi.org/10.1055/s-0038-1657766
  14. Chowdhury R, Sinha B, Sankar MJ, Taneja S, Bhandari N, Rollins N, et al. Breastfeeding and maternal health outcomes: a systematic review and meta-analysis. Acta Paediatr. 2015;104(467):96-113. https://doi.org/10.1111/apa.13102
  15. Yi X, Zhu J, Zhu X, Liu GJ, Wu L. Breastfeeding and thyroid cancer risk in women: a dose-response meta-analysis of epidemiological studies. Clin Nutr. 2016;35(5):1039-1046. https://doi.org/10.1016/j.clnu.2015.12.005
  16. Kim Y, Choi JY, Lee KM, Park SK, Ahn SH, Noh DY, et al. Dose-dependent protective effect of breast-feeding against breast cancer among ever-lactated women in Korea. Eur J Cancer Prev. 2007;16(2):124-129. https://doi.org/10.1097/01.cej.0000228400.07364.52
  17. Lee SY, Kim MT, Kim SW, Song MS, Yoon SJ. Effect of lifetime lactation on breast cancer risk: a Korean women's cohort study. Int J Cancer. 2003;105(3):390-393. https://doi.org/10.1002/ijc.11078
  18. Kim H, Kim KY, Baek JH, Jung J. Are pregnancy, parity, menstruation and breastfeeding risk factors for thyroid cancer? Results from the Korea National Health and Nutrition Examination Survey, 2010-2015. Clin Endocrinol (Oxf). 2018;89(2):233-239. https://doi.org/10.1111/cen.13750
  19. Kim Y, Han BG; KoGES group. Cohort profile: The Korean Genome and Epidemiology Study (KoGES) Consortium. Int J Epidemiol. 2017;46(2):e20. https://doi.org/10.1093/ije/dyv316
  20. Park B, Park S, Shin HR, Shin A, Yeo Y, Choi JY, et al. Population attributable risks of modifiable reproductive factors for breast and ovarian cancers in Korea. BMC Cancer. 2016;16:5. https://doi.org/10.1186/s12885-015-2040-0
  21. Manole D, Schildknecht B, Gosnell B, Adams E, Derwahl M. Estrogen promotes growth of human thyroid tumor cells by different molecular mechanisms. J Clin Endocrinol Metab. 2001;86(3):1072-1077. https://doi.org/10.1210/jcem.86.3.7283
  22. Xhaard C, Rubino C, Clero E, Maillard S, Ren Y, Borson-Chazot F, et al. Menstrual and reproductive factors in the risk of differentiated thyroid carcinoma in young women in France: a population-based case-control study. Am J Epidemiol. 2014;180(10):1007-1017. https://doi.org/10.1093/aje/kwu220
  23. Kim CS. Thyroid cancer and radiation. J Korean Thyroid Assoc. 2015;8(1):1-7. https://doi.org/10.11106/cet.2015.8.1.1
  24. Maamri A, El Hfid M, Chafi A, Boutayeb A. Cervix and breast cancers in Oujda city in Eastern Morocco: determinants and risk factors. Open J Prev Med. 2012;2(1):9-15. https://doi.org/10.4236/ojpm.2012.21002
  25. Yu P, Wang Y, Li C, Lv L, Wang J. Protective effects of downregulating estrogen receptor alpha expression in cervical cancer. Anticancer Agents Med Chem. 2018;18(14):1975-1982. https://doi.org/10.2174/1871520618666180830162517
  26. Ma X, Zhao LG, Sun JW, Yang Y, Zheng JL, Gao J, et al. Association between breastfeeding and risk of endometrial cancer: a meta-analysis of epidemiological studies. Eur J Cancer Prev. 2018;27(2):144-151. https://doi.org/10.1097/CEJ.0000000000000186
  27. Cohen PA, Jhingran A, Oaknin A, Denny L. Cervical cancer. Lancet. 2019;393(10167):169-182. https://doi.org/10.1016/S0140-6736(18)32470-X
  28. Choi EJ. Breastfeeding-related social environmental factors and their policy implications. Bogeonbokji Forum. 2017;(249):72-81.
  29. Victora CG, Bahl R, Barros AJ, Franca GV, Horton S, Krasevec J, et al. Breastfeeding in the 21st century: epidemiology, mechanisms, and lifelong effect. Lancet. 2016;387(10017):475-490. https://doi.org/10.1016/S0140-6736(15)01024-7