International Journal of Industrial Entomology and Biomaterials

Korean Society of Sericultural Science (한국잠사학회)
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Papiliocin, an antimicrobial peptide, rescues hyperoxia-induced intestinal injury

  • Kim, Seong Ryul (Sericultural and Apicultural Materials Division, National Institute of Agricultural Sciences, RDA) ;
  • Park, Seung-Won (Department of Biomedical Science, Daegu Catholic University)
  • Received : 2021.11.03
  • Accepted : 2021.12.17
  • Published : 2021.12.31
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Abstract

Reactive oxygen species (ROS) induce a variety of cellular responses, such as proliferation, differentiation, senescence, and apoptosis. Intestinal epithelial cells are continuously exposed to ROS, and excessive generation of ROS severely damages cells via oxidative stress. Pro-inflammatory cytokines may lead to intestinal inflammation and damage by inducing excessive ROS generation. In this study, we showed that papiliocin, an antimicrobial peptide, significantly inhibited ROS production, without affecting cell viability. Moreover, TNF-α and IL-6 expression was decreased in the intestinal epithelial cells. The activity of papiliocin may significantly contribute to preserving the integrity of the intestinal mucosa against oxidative damage and inflammation-related disorders.

Keywords

Acknowledgement

This study was supported by a grant from the grant no. PJ016231, Rural Development Administration, Republic of Korea.

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