Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지
DOI QR코드

DOI QR Code

Chemical Constituents from Aegle marmelos Fruits

  • Kim, Hye Jin (College of Pharmacy and Integrated Research Institute of Pharmaceutical Sciences, The Catholic University of Korea) ;
  • Seo, Young Ju (College of Pharmacy and Integrated Research Institute of Pharmaceutical Sciences, The Catholic University of Korea) ;
  • Htwe, Khin Myo (Popa Mountain Park, Forest Department, Kyaukpadaung Township) ;
  • Yoon, Kee Dong (College of Pharmacy and Integrated Research Institute of Pharmaceutical Sciences, The Catholic University of Korea)
  • Received : 2021.11.18
  • Accepted : 2021.12.11
  • Published : 2021.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

Aegle marmelos (Rutaceae) is a deciduous shrub or tree and typically known as bael throughout Southeast Asia and has been used as a medicinal plant and a food ingredient. In this study eight compounds were determined to be O-(3,3-dimethylallyl) halfordinol (1), (R)-aegeline (2), (R)-marmeline (3), imperatorin (4), xanthotoxol (5), valencic acid (6), vanillic acid (7) and rutin (8). The chemical structures of the isolates were elucidated through spectroscopic evidence including 1D, 2D NMR, ESI-Q-TOF-MS and optical rotation.

Keywords

Acknowledgement

This work was supported by the National Foundation of Korea (Grant No. 2018R1A6A1A03025108) and a research fund, 2021 of the Catholic University of Korea.

References

  1. Pathirana, C. K.; Madhujith, T.; Eeswara, J. Adv. Agric. 2020, 2020, 8814018.
  2. Shinde, P. B.; Katehaye, S. D.; Mulik, M. B.; Laddha, K. S. J. Food Sci. Technol. 2014, 51, 2251-2255. https://doi.org/10.1007/s13197-014-1270-5
  3. Rahman, A. U.; Imran, H.; Taqvi, S. I. H.; Sohail, T.; Yaqeen, Z.; Rehman, Z. U.; Fatima, N. Pak. J. Pharm. Sci. 2015, 28, 515-519.
  4. Arul, V.; Miyazaki, S.; Dhananjayan, R. Phytomedicine 2004, 11, 679-683. https://doi.org/10.1016/j.phymed.2002.12.001
  5. Lambertini, E.; Lampronti, I.; Penolazzi, L.; Khan, M. T. H.; Ather, A.; Giorgi, G.; Gambari, R.; Piva, R. Oncol. Res. 2005, 15, 69-79. https://doi.org/10.3727/096504005775082057
  6. Das, S. K.; Roy, C. Saudi J. Gastroenterol. 2012, 18, 188-194. https://doi.org/10.4103/1319-3767.96452
  7. Saravanan, M; Pandikumar, P.; Saravanan, S.; Toppo, E.; Pazhanivel, N.; Ignacimuthu, S. Eur. J. Pharmacol. 2014, 740, 714-721. https://doi.org/10.1016/j.ejphar.2014.06.004
  8. Robles, A. J.; McCowen, S.; Cai, S.; Glassman, M.; Ruiz, F. 2nd; Cichewicz, R. H.; McHardy, S. F.; Mooberry, S. L. J. Med. Chem. 2017, 60, 9275-9289. https://doi.org/10.1021/acs.jmedchem.7b01228
  9. Hasbum, C.; Castro, O. J. Nat. Prod. 1988, 51, 817-818. https://doi.org/10.1021/np50058a035
  10. Saravanan, M.; Pandikumar, P.; Saravanan, S.; Toppo, E.; Pazhanivel, N.; Ignacimuthu, S. Eur. J. Pharmacol. 2014, 740, 714-721. https://doi.org/10.1016/j.ejphar.2014.06.004
  11. Faizi, S.; Farooqi, F.; Zikr-Ur-Rehman, S.; Naz, A.; Noor, F.; Ansari, F.; Ahmad, A.; Khan, S. A. Tetrahedron 2009, 65, 998-1004. https://doi.org/10.1016/j.tet.2008.11.088
  12. Yadav, J. S.; Reddy, P. T.; Nanda, S.; Rao, A. B. Tetrahedron Asymmetry 2001, 12, 3381-3385. https://doi.org/10.1016/S0957-4166(02)00024-1
  13. Govindachari, T. R.; Premila, M. S. Phytochemistry 1983, 22, 755-757. https://doi.org/10.1016/S0031-9422(00)86977-0
  14. Chakthong, S.; Weaaryee, P.; Puangphet, P.; Mahabusarakam, W.; Plodpai, P.; Voravuthikunchai, S. P.; Kanjana-Opas, A. Phytochemistry 2012, 75, 108-113. https://doi.org/10.1016/j.phytochem.2011.11.018
  15. Baek, N. I.; Ahn, E. M.; Kim, H. Y.; Park, Y. D. Arch. Pharm. Res. 2000, 23, 467-470. https://doi.org/10.1007/BF02976574
  16. Youn, U. J.; Yoo, J. K.; Chen, Q. C.; Lee, I. S.; Na, M.; Min, B. S.; Jung, H. J.; Seo, E. K.; Bae, K. Kor. J. Pharmacol. 2010, 41, 185-189.
  17. Ito, C.; Mizuno, T.; Matsuoka, M.; Kimura, Y.; Sato, K.; Kajiura, I.; Omura, M.; Ju-ichi, M.; Furukawa, H. Chem. Pharm. Bull. 20, 36, 3292-3295. https://doi.org/10.1248/cpb.36.3292
  18. Lee, C. K.; Lu, C. K.; Kuo, Y. H.; Chen, J. Z.; Sun, G. Z. J. Chin. Chem. Soc. 2004, 51, 437-441. https://doi.org/10.1002/jccs.200400067
  19. Han, J. T.; Bang, M. H.; Chun, O. K.; Kim, D. O.; Lee, C. Y.; Baek, N. I. Arch. Pharm. Res. 2004, 27, 390-395. https://doi.org/10.1007/BF02980079