Korean Journal of Head & Neck Oncology (대한두경부종양학회지)

The Korean Society for Head and Neck Oncology (대한두경부종양학회)
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The Status and Treatment Outcomes in Patients with Hypopharyngeal Cancer: A Nationwide Population-based Study

하인두암 환자들의 발생 현황 및 치료 방법에 따른 결과 분석: 국민건강보험공단 자료를 이용한 연구

  • Kim, Hyun-Bum (Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea) ;
  • Han, Kyung-Do (Department of Statistics and Actuarial Science, The Soongsil University of Korea) ;
  • Joo, Young-Hoon (Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea)
  • 김현범 (가톨릭대학교 이비인후과교실) ;
  • 한경도 (숭실대학교 정보통계, 보험수리학과) ;
  • 주영훈 (가톨릭대학교 이비인후과교실)
  • Received : 2021.05.20
  • Accepted : 2021.11.12
  • Published : 2021.11.30
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Abstract

Background/Objectives: The aim of this national population-based retrospective study was to analyze the status and treatment outcome in patients with hypopharyngeal cancer. Materials & Methods: Participants were included in the KNHIS national sample cohort who received a KNHIS health check-up in 2008 and 2009, and we followed these individuals until 2017. Patients were defined as having hypopharynx cancer if they had admissions records for hypopharynx cancer in their national health insurance data from 2010 to 2017. Results: The study cohort included 3,922 patients. According to our nationwide data, 3,533(90.1%) were male with a median age of 65.03±11.04 years at the time of diagnosis. Among parametric models for hypopharyngeal cancer prognosis, old age (Hazard ratio [HR]:1.92; 95% confidence interval[CI]:1.76-2.09), female (HR:0.77; 95% CI:0.66-0.89), and low socioeconomic status (HR:1.216; 95% CI:1.114-1.327) were significantly associated with survival. Compared with concurrent chemoradiotherapy, patients who received no treatment (HR, 1.88; 95% CI, 1.31-2.70), neoadjuvant chemotherapy followed by surgery (HR, 1.21; 95% CI, 1.04-1.41), and chemotherapy alone (HR, 1.16; 95% CI, 1.03-1.27) showed poor prognosis in hypopharyngeal cancer. Conclusion: Our data indicated that age, sex, and income were significant predictors of lifetime survival in patients with hypopharyngeal cancer. Treatment modalities were also associated with prognosis. The data have implications for treatment investigations and prevention strategies.

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References

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