The Journal of Pediatrics of Korean Medicine (대한한방소아과학회지)

The Association of Korean Oriental Pediatrics (대한한방소아과학회)
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Rview of Recent Clinical Research for Herbal Medicine Treatment on Vitiligo in Children - Focused on Chinese Randomized Controlled Trials -

소아 백반증의 한약 치료에 대한 최신 임상 연구 동향 - 중국 무작위 대조군 연구를 중심으로 -

  • Jang, Jin Woo (School of Korean Medicine, Pusan National University) ;
  • Choi, Il Shin (Dept. of Korean Pediatrics, Korean Medicine Hospital, Pusan National University) ;
  • Park, Beom Chan (School of Korean Medicine, Pusan National University) ;
  • Kim, Ki Bong (School of Korean Medicine, Pusan National University) ;
  • Cheon, Jin Hong (School of Korean Medicine, Pusan National University)
  • 장진우 (부산대학교 한의학 전문대학원) ;
  • 최일신 (부산대학교한방병원 한방소아과) ;
  • 박범찬 (부산대학교 한의학 전문대학원) ;
  • 김기봉 (부산대학교 한의학 전문대학원) ;
  • 천진홍 (부산대학교 한의학 전문대학원)
  • Received : 2021.10.25
  • Accepted : 2021.11.19
  • Published : 2021.11.30
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Abstract

Objective The purpose of this study is to gather information from clinical studies conducted in China and analyze the effects of herbal medicine treatment for childhood vitiligo. Methods The randomized controlled trials (RCTs) with herbal medicine treatment for childhood vitiligo from the Chinese Academic Journal (CAJ) from China National Knowledge Infrastructure (CNKI) were searched. Then, each study was analyzed by demographics, disease durations, interventions, treatment periods, outcomes, adverse events, and compositions of the herbal medicine used. Result A total of 6 RCTs were included. All the trials except for one used a combination of Chinese herbal medicine with Western medicine as their treatment groups. The total efficacy rate was used to measure the effectiveness, and the treatment groups reported a significantly higher total efficacy rate compared to the control groups in all studies. In one study, a control group treated with compound glycyrrhizin capsule and topical compound kaliziran tincture combination treatment was compared with a treatment group which used the same treatment that the control group received in addition to oral herbal medicine. This study also showed higher total effectiveness in the treatment group than the control group. Conclusions In pediatric vitiligo, a combination of herbal medicine treatment rather than Western medical treatment alone can improve symptoms. In addition, it was suggested that the therapeutic effect can be enhanced when oral herbal medicine is used in combination with other herbal medicine treatments.

Keywords

Acknowledgement

이 논문은 부산대학교 기본연구지원사업 (2년)에 의하여 연구되었음.

References

  1. Oh SH. Classification and diagnosis of vitiligo. J Korean Med Assoc. 2020;63(12):731-40. https://doi.org/10.5124/jkma.2020.63.12.731
  2. Taieb A, Picardo M; VETF Members. The definition and assessment of vitiligo: a consensus report of the Vitiligo European Task Force. Pigment Cell Res. 2007; 20:27-35. https://doi.org/10.1111/j.1600-0749.2006.00355.x
  3. Ezzedine K, Silverberg N. A practical approach to the diagnosis and treatment of vitiligo in children. Pediatr. 2016;138(1):1-14.
  4. Spritz RA, Anderson GH. Genetics of vitiligo. Dermatol Clin. 2017;35(2):245-55. https://doi.org/10.1016/j.det.2016.11.013
  5. Boniface K, Seneschal J, Picardo M, Taieb A. Vitiligo: focus on clinical aspects, immunopathogenesis, and therapy. Clin Rev Allergy Immunol. 2018;54(1):52-7. https://doi.org/10.1007/s12016-017-8622-7
  6. Kim DJ, Lee UH, Kim MS. Assessment of the quality of life in Korean patients with vitiligo. J Korean Dermatol. 2016;54(6):409-21.
  7. Hong YH, Kim SW, Cho YC. Four cases of Soyangins vitiligo patients gotten better by oriental medical treatment who have the symptoms in the hans. J Korean Med Ophthalmol Otolaryngol Dermatol. 2015;28(1): 152-9. https://doi.org/10.6114/JKOOD.2015.28.1.152
  8. Lee JH, Kim SY. Four cases of vitiligo patients treated by oriental medical treatment who have experienced Excimer laser treatment. J Korean Med Ophthalmol Otolaryngol Dermatol. 2014;27(3):205-12. https://doi.org/10.6114/JKOOD.2014.27.3.205
  9. Park SG, Park SH, Lee SH, Lee JY. A review of clinical researches for herbal medicine treatment on vitiligo. J Pediatr Korean Med. 2020;34(2):57-74. https://doi.org/10.7778/JPKM.2020.34.2.57
  10. Chen XR. Clinical observation on the treatment of 39 cases of vitiligo in children with deficiency of spleen and stomach by self-made Jianpi Xiaobai Decoction combined with 308 excimer laser. Shanxi J Chin Med. 2020;49(15):2046-8
  11. Han XW, Li T, Zhang T. Clinical study of traditional Chinese medicine combined with tacrolimus ointment in treating 35 cases of spleen and stomach weakness in children with vitiligo. Chin J DV Integr Med. 2018;17(6):512-5.
  12. Luo GP, Wang TJ, Ren YY, Zhu GH. Regulatory effect of modified Guizhitang on immune function of atients with vitiligo with qi-blood circulation. Chin J Experimental Traditional Med Formulae. 2017;23(22): 188-93.
  13. Gao DW, Cai RK. All-Day Comprehensive therapy for children vitiligo. World Journal of Integrated Traditional and Western Medicine. 2015;10(3):362-5.
  14. Wang LH, Zhang YQ. Effect of combined therapy of traditional Chinese and Western medicine on children's vitiligo, Journal of Clinical Medicine in Practice. 2014;18(17):172-3.
  15. Wang SC, Song L, Li L, Wang S. Clinical observation on treatment of 90 cases of vitiligo in children with self-made Xiaobai decoction combined with compound glycyrrhizin and compound Kali Cumin tincture. J Tradit Chin Med. 2014;55(16):1398-400.
  16. Tamihiro K, Takashi H. Disease severity indexes and treatment evaluation criteria in vitiligo. Dermatology Research and Practice. 2011;2011:750342.
  17. Kwak TJ, Chang MY, Lee SM, Park SK, Park SM. Comparative study of melanin content in corneocyte with skin color. J Soc Cosmet Scientists Kor. 2010;36(3):193-8.
  18. Kim IR, Kim HC, Kuk YB, Park SJ, Park YG, Park JH, Seo BI, Seo YB, Song HJ, Shin MK, Lee YJ, Lee YC, Lee JH, Lim GH, Jo SI, Jung JG, Joo YS, Choi HY. Bonchohak. 2nd ed. Seoul: Young Lim Sa Publishing Co. 2012:578-9.
  19. Kim IR, Kim HC, Kuk YB, Park SJ, Park YG, Park JH, Seo BI, Seo YB, Song HJ, Shin MK, Lee YJ, Lee YC, Lee JH, Lim GH, Jo SI, Jung JG, Joo YS, Choi HY. Bonchohak. 2nd ed. Seoul: Young Lim Sa Publishing Co. 2012:163-4.
  20. Yu MA. Studies on regulation of skin anti-aging related proteins in Angelica Gigas Nakai extracts and decursin-stimulated human dermal fibroblast [Doctorate]. [Suwon]: Ajou University Graduate School; 2011 Feb. 125p.
  21. Gu JE. Effect of angelic acid on cellular senescence, anti-oxidation, and DNA repair mechanism in human dermal fibroblasts [Doctorate]. [Seoul]: Konkuk University Graduate School; 2016 Feb. 82p.
  22. Shin SH. Anti-inflammatory effects of ethanol extract of Angelica Gigantis Radix [Doctorate]. [Cheongju]: Chungbuk University Veterinary; 2008 Feb. 159p.
  23. Jeong AR, Lee JY, Chang GT, Lee SH, Lee JH, Baek JH, Lee HR, Ku EJ, Kim JH, Min SY, Kim BNR, Yu SA, Kwon JH, Kim KB, Cheon JH, Jeong HS, Seong HG, Jeong MJ, Park EJ. Pediatrics of Korean medicine. 3rd ed. Seoul: Ui Sung Dang Publishing Co. 2020:30.
  24. Jeong AR, Lee JY, Chang GT, Lee SH, Lee JH, Baek JH, Lee HR, Ku EJ, Kim JH, Min SY, Kim BNR, Yu SA, Kwon JH, Kim KB, Cheon JH, Jeong HS, Seong HG, Jeong MJ, Park EJ. Pediatrics of Korean medicine. 3rd ed. Seoul: Ui Sung Dang Publishing Co. 2020:881-2.
  25. Kim HJ, Sung HC, Park KD, Na GY, Lee WJ, Lee SJ, Kim DW. The effects of tacrolimus on keratinocytes and melanocytes of vitiligo. J Kor Dermatol. 2006; 44(6):708-13.
  26. Finaly AT, Khan GK. Dermatology life quality index (DLQI): a simple practical measure for routine clinical use. Clin Exp Dermatol. 1994;19:210-6. https://doi.org/10.1111/j.1365-2230.1994.tb01167.x
  27. Kim DJ, Lee UH, Kim MS. Assessment of the quality of life in Korean patients with vitiligo. J Kor Dermatol. 2016;54(6):409-21.
  28. Xu W, Li Y, Ju M, Lai W, Lu XY, Shi HJ, Shi WM, Gu H, Li LF. A multicenter, randomized, double-blind, placebo-controlled study of compound Glycyrrhizin capsules combined with a topical corticosteroid in adults with chronic eczema. Evid Based Complement Alternat Med. 2020;2020:6127327.
  29. Yang D, Zheng J, Zhang Y, Jun Y, Gan C. Total glucosides of paeony capsule plus compound glycyrrhizin tablets for the treatment of severe alopecia areata in children: a randomized controlled trial. Evid Based Complement Alternat Med. 2013;2013:378219.
  30. Wu WZ, Zhang FR. Glycyrrhizin combined with acitretin improve clinical symptom of psoriasis via reducing + 17 cell differentiation and related serum cytokine concentration. Int J Clinical Experimental Med. 2015; 8(8):16266-72.
  31. Mou KH, Han D, Liu WL, Li P. Combination therapy of orally administered glycyrrhizin and UVB improved active-stage generalized vitiligo. Braz J Med Biol Res. 2016;49(8):e5354. https://doi.org/10.1590/1414-431x20165354
  32. Silverberg JI, Silverberg NB. Quality of life impairment in children and adolescents with vitiligo. Pediatr Dermatol. 2014;31(3):309-18. https://doi.org/10.1111/pde.12226
  33. Lewis-Jones MS, Finlay AY. The children's dermatology life quality index (CDLQI): initial validation and practical use. Br J Dermatol. 1995;132(6):942-9. https://doi.org/10.1111/j.1365-2133.1995.tb16953.x