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A Study on the Preparation of 5(6)-Carboxyflurescein-supported Phospholipid Liposomes and Evaluation of Bacterial Sensing Ability

5(6)-Carboxyflurescein을 담지한 인지질 리포좀의 제조 및 박테리아 센싱 능력 평가에 대한 연구

  • Received : 2021.12.01
  • Accepted : 2021.12.21
  • Published : 2021.12.27

Abstract

In the case of occlusive dressings currently used in dressings for burn treatment, it is impossible to confirm the replacement time, so replacement is delayed, resulting in additional infection. To solve this problem, liposomes capable of bacterial sensing were prepared using 5(6)-Carboxyfluorescein, Phosphatidylcholine, 1,2-Dipalmitoyl-sn-glycero-3-phosphocholine, Cholesterol, and 10,12-Tricosadiynoic acid. In this study, evaluation of changes in drug encapsulation rate in liposomes according to changes in three types of phosphatidylcholine phospholipids during liposome production, high-performance phosphatidylcholine phospholipids selected through vesicle size analysis, low and high temperature stability evaluation, bacterial sensitization ability evaluation, animals cell responses were assessed.

Keywords

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