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DOI QR Code

Migrating Cells Dispose of Damaged Mitochondria into the Surrounding Environment

  • Lee, Choong-Sil (Integrated OMICS for Biomedical Science, World Class University, Yonsei University) ;
  • Song, Jaewhan (Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University)
  • Received : 2021.10.18
  • Accepted : 2021.10.20
  • Published : 2021.11.30

Abstract

Keywords

Acknowledgement

This work was supported by a grant from the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT, and Future Planning (MSIP) (2015R1 A3A2066581), in part by a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (No. NRF-2020R1A5A1019023).

References

  1. Denisenko, T.V., Gorbunova, A.S., and Zhivotovsky, B. (2019). Mitochondrial involvement in migration, invasion and metastasis. Front. Cell Dev. Biol. 7, 355. https://doi.org/10.3389/fcell.2019.00355
  2. Jiang, D., Jiang, Z., Lu, D., Wang, X., Liang, H., Zhang, J., Meng, Y., Li, Y., Wu, D., Huang, Y., et al. (2019). Migrasomes provide regional cues for organ morphogenesis during zebrafish gastrulation. Nat. Cell Biol. 21, 966-977. https://doi.org/10.1038/s41556-019-0358-6
  3. Jiao, H., Jiang, D., Hu, X., Du, W., Ji, L., Yang, Y., Li, X., Sho, T., Wang, X., Li, Y., et al. (2021). Mitocytosis, a migrasome-mediated mitochondrial qualitycontrol process. Cell 184, 2896-2910.e13. https://doi.org/10.1016/j.cell.2021.04.027
  4. Jung, J., Zeng, H., and Horng, T. (2019). Metabolism as a guiding force for immunity. Nat. Cell Biol. 21, 85-93. https://doi.org/10.1038/s41556-018-0217-x
  5. Ma, L., Li, Y., Peng, J., Wu, D., Zhao, X., Cui, Y., Chen, L., Yan, X., Du, Y., and Yu, L. (2015). Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration. Cell Res. 25, 24-38. https://doi.org/10.1038/cr.2014.135
  6. Meyer, J.N., Leuthner, T.C., and Luz, A.L. (2017). Mitochondrial fusion, fission, and mitochondrial toxicity. Toxicology 391, 42-53. https://doi.org/10.1016/j.tox.2017.07.019
  7. Song, J., Herrmann, J.M., and Becker, T. (2021). Quality control of the mitochondrial proteome. Nat. Rev. Mol. Cell Biol. 22, 54-70. https://doi.org/10.1038/s41580-020-00300-2
  8. Trepat, X., Chen, Z., and Jacobson, K. (2012). Cell migration. Compr. Physiol. 2, 2369-2392. https://doi.org/10.1002/cphy.c110012