Acknowledgement
본 연구는 한국연구재단(No. 2017R1A2B4004933)의 지원에 의해 수행되었습니다.
References
- Liao JF, Wang HH, Chen MC, Chen CC, Chen CF. Benzodiazepine binding site-interactive flavones from Scutellaria baicalensis root. Planta Med. 1998 ;64(6):571-2. https://doi.org/10.1055/s-2006-957517
- Kim YJ, Kim HJ, Lee JY, Kim DH, Kang MS, Park W. Anti-Inflammatory Effect of Baicalein on Polyinosinic-Polycytidylic Acid-Induced RAW 264.7 Mouse Macrophages. Viruses. 2018 ;10(5):224. https://doi.org/10.3390/v10050224
- Fan GW, Zhang Y, Jiang X, Zhu Y, Wang B, Su L, Cao W, Zhang H, Gao X. Anti-inflammatory activity of baicalein in LPS-stimulated RAW264.7 macrophages via estrogen receptor and NF-κB-dependent pathways. Inflammation. 2013; 36(6):1584-91. https://doi.org/10.1007/s10753-013-9703-2
- Lee W, Ku SK, Bae JS. Anti-inflammatory effects of Baicalin, Baicalein, and Wogonin in vitro and in vivo. Inflammation. 2015;38(1):110-25. https://doi.org/10.1007/s10753-014-0013-0
- Lee JY, Park W. Anti-Inflammatory Effect of Wogonin on RAW 264.7 Mouse Macrophages Induced with Polyinosinic-Polycytidylic Acid. Molecules. 2015;20(4): 6888-900. https://doi.org/10.3390/molecules20046888
- Kim HJ, Kim YJ, Park W. Berberine modulates hyper-inflammation in mouse macrophages stimulated with polyinosinic-polycytidylic acid via calcium- CHOP/STAT pathway. Sci Rep. 2021;11(1): 11298. https://doi.org/10.1038/s41598-021-90752-z
- DH, Lee JY, Kim YJ, Kim HJ, Park W. Rubi Fructus Water Extract Alleviates LPS-Stimulated Macrophage Activation via an ER Stress-Induced Calcium/CHOP Signaling Pathway. Nutrients. 2020 ;12(11):3577. https://doi.org/10.3390/nu12113577
- Kim YJ, Lee JY, Kim HJ, Kim DH, Lee TH, Kang MS, Park W. Anti-Inflammatory Effects of Angelica sinensis (Oliv.) Diels Water Extract on RAW 264.7 Induced with Lipopolysaccharide. Nutrients. 2018 ;10(5):647. https://doi.org/10.3390/nu10050647
- Svechnikov K, Landreh L, Weisser J, Izzo G, Colon E, Svechnikova I, Soder O. Origin, development and regulation of human Leydig cells. Horm Res Paediatr. 2010;73(2):93-101. https://doi.org/10.1159/000277141
- nee Pathak ND, Lal B. Nitric oxide: An autocrine regulator of Leydig cell steroidogenesis in the Asian catfish, Clarias batrachus. Gen Comp Endocrinol. 2008 Sep 1;158(2):161-7. https://doi.org/10.1016/j.ygcen.2008.06.009
- Park WH, Chang MS, Yang WM, Bae H, Kim NI, Park SK. Cytoprotective effect of Panax ginseng on gallic acid-induced toxicity in TM3 mouse Leydig cells. Fitoterapia. 2007;78(7-8):577-9. https://doi.org/10.1016/j.fitote.2007.03.019
- Park WS. Study on Biological Effect of Multi-Herbal Drug KOCO-P1 on Human Hepatocytes (HepG2). The Korean Journal of Herbology. 2008;23(3):149-54.
- Park WS. Effect of Water Extract from Artemisiae Argi Folium on Mouse Macrophage Stimulated by LPS. The Korean Journal of Herbology. 2009;24(1):151-7.
- Lee JY, Lee YJ, Park WS. Anti-inflammatory Effects of Fermented Houttuyniae Herba Water Extract on LPS-induced Mouse Macrophage. The Korean Journal of Herbology. 2010;25(3):27-34.
- Gao D., Sakurai K., Chen J., Ogiso T. Protection by baicalein against ascorbic acid-induced lipid peroxidation of rat liver microsomes. Res. Commun. Mol. Pathol. Pharmacol. 1995;90:103-114.
- Huang H.C., Wang H.R., Hsieh L.M. Antiproliferative effect of baicalein, a flavonoid from a Chinese herb, on vascular smooth muscle cell. Eur. J. Pharmacol. 1994;251:91-93. https://doi.org/10.1016/0014-2999(94)90447-2
- Michibayashi T. Platelet aggregating response to platelet activating factor participates in activation of the 12-lipoxygenase pathway in platelets from rabbits. Int. Angiol. 2002;21:260-267.
- Kimura Y., Okuda H., Ogita Z. Effects of flavonoids isolated from scutellariae radix on fibrinolytic system induced by trypsin in human umbilical vein endothelial cells. J. Nat. Prod. 1997;60:598-601. https://doi.org/10.1021/np970035l
- Wartenberg M., Budde P., De Marees M., Grunheck F., Tsang S.Y., Huang Y., Chen Z.Y., Hescheler J., Sauer H. Inhibition of tumor-induced angiogenesis and matrix-metalloproteinase expression in confrontation cultures of embryoid bodies and tumor spheroids by plant ingredients used in traditional chinese medicine. Lab. Investig. 2003;83:87-98. https://doi.org/10.1097/01.LAB.0000049348.51663.2F
- Park BB, Choi JW, Park D, Choi D, Paek J, Kim HJ, Son SY, Mushtaq AU, Shin H, Kim SH, Zhou Y, Lim T, Park JY, Baek JY, Kim K, Kwon H, Son SH, Chung KY, Jeong HJ, Kim HM, Jung YW, Lee K, Lee KY, Byun Y, Jeon YH. Structure-Activity Relationships of Baicalein and its Analogs as Novel TSLP Inhibitors. Sci Rep. 2019;9(1):8762. https://doi.org/10.1038/s41598-019-44853-5
- Bai H, Yuan R, Zhang Z, Liu L, Wang X, Song X, Ma T, Tang J, Liu C, Gao L. Intra-articular Injection of Baicalein Inhibits Cartilage Catabolism and NLRP3 Inflammasome Signaling in a Posttraumatic OA Model. Oxid Med Cell Longev. 2021;2021:6116890.
- He S, Wang S, Liu S, Li Z, Liu X, Wu J. Baicalein Potentiated M1 Macrophage Polarization in Cancer Through Targeting PI3Kγ/ NF-κB Signaling. Front Pharmacol. 2021;12:743837. https://doi.org/10.3389/fphar.2021.743837
- Chen M, Peng L, Gong P, Zheng X, Sun T, Zhang X, Huo J. Baicalein Mediates Mitochondrial Autophagy via miR-30b and the NIX/BNIP3 Signaling Pathway in Parkinson's Disease. Biochem Res Int. 2021 ;2021:2319412.
- Cai P, Lu Y, Yin Z, Wang X, Zhou X, Li Z. Baicalein ameliorates osteoporosis via AKT/FOXO1 signaling. Aging (Albany NY). 2021;13(13):17370-17379.
- Zandi K, Musall K, Oo A, Cao D, Liang B, Hassandarvish P, Lan S, Slack RL, Kirby KA, Bassit L, Amblard F, Kim B, AbuBakar S, Sarafianos SG, Schinazi RF. Baicalein and Baicalin Inhibit SARSCoV- 2 RNA-Dependent-RNA Polymerase. Microorganisms. 2021;9(5):893. https://doi.org/10.3390/microorganisms9050893
- Yang Y, Song Y, Nie Q, Tian R, Huang J, Mao G. Baicalein inhibits invasion and promotes apoptosis in glioma cells through the PI3K/Akt pathway. J BUON. 2021;26(2):395-401.
- Zhu Y, Peng X, Zhang Y, Lin J, Zhao G. Baicalein Protects Against Aspergillus fumigatus Keratitis by Reducing Fungal Load and Inhibiting TSLPInduced Inflammatory Response. Invest Ophthalmol Vis Sci. 2021;62(6):26.
- Ren M, Zhao Y, He Z, Lin J, Xu C, Liu F, Hu R, Deng H, Wang Y. Baicalein inhibits inflammatory response and promotes osteogenic activity in periodontal ligament cells challenged with lipopolysaccharides. BMC Complement Med Ther. 2021;21(1):43. https://doi.org/10.1186/s12906-021-03213-5
- Hou YC, Janczuk A, Wang PG. Current trends in the development of nitric oxide donors. Curr Pharm Des. 1999;5(6):417-41.
- Tsopka IC, Hadjipavlou-Litina D. Hybrids as NO Donors. Int J Mol Sci. 2021;22(18):9788. https://doi.org/10.3390/ijms22189788
- Lue Y, Sinha Hikim AP, Wang C, Leung A, Swerdloff RS. Functional role of inducible nitric oxide synthase in the induction of male germ cell apoptosis, regulation of sperm number, and determination of testes size: evidence from null mutant mice. Endocrinology. 2003;144(7): 3092-100. https://doi.org/10.1210/en.2002-0142
- Su X, Lin D, Luo D, Sun M, Wang X, Ye J, Zhang M, Zhang Y, Xu X, Yu C, Guan Q. Cyclophilin D participates in the inhibitory effect of high-fat diet on the expression of steroidogenic acute regulatory protein. J Cell Mol Med. 2019; 23(10):6859-6871. https://doi.org/10.1111/jcmm.14569
- Bianchi VE, Locatelli V. Testosterone a key factor in gender related metabolic syndrome. Obes Rev. 2018;19(4):557-575. https://doi.org/10.1111/obr.12633
- DM, Jones H. Testosterone: a metabolic hormone in health and disease. J Endocrinol. 2013;217(3): R25-45. https://doi.org/10.1530/JOE-12-0455
- Peterson MD, Belakovskiy A, McGrath R, Yarrow JF. Testosterone deficiency, weakness, and multimorbidity in men. Sci Rep. 2018;8(1):5897. https://doi.org/10.1038/s41598-018-24347-6