References
- Armstrong, J.A., Cash, N.J., Ouyang, Y., Morton, J.C., Chvanov, M., Latawiec, D., Awais, M., Tepikin, A.V., Sutton, R., and Criddle, D.N. (2018). Oxidative stress alters mitochondrial bioenergetics and modifies pancreatic cell death independently of cyclophilin D, resulting in an apoptosis-tonecrosis shift. J. Biol. Chem. 293, 8032-8047. https://doi.org/10.1074/jbc.RA118.003200
- Bozic, I., Savic, D., Laketa, D., Bjelobaba, I., Milenkovic, I., Pekovic, S., Nedeljkovic, N., and Lavrnja, I. (2015). Benfotiamine attenuates inflammatory response in LPS stimulated BV-2 microglia. PLoS One 10, e0118372. https://doi.org/10.1371/journal.pone.0118372
- Cubillos-Ruiz, J.R., Silberman, P.C., Rutkowski, M.R., Chopra, S., Perales-Puchalt, A., Song, M., Zhang, S., Bettigole, S.E., Gupta, D., Holcomb, K., et al. (2015). ER stress sensor XBP1 controls anti-tumor immunity by disrupting dendritic cell homeostasis. Cell 161, 1527-1538. https://doi.org/10.1016/j.cell.2015.05.025
- Dellinger, R.P., Levy, M.M., Rhodes, A., Annane, D., Gerlach, H., Opal, S.M., Sevransky, J.E., Sprung, C.L., Douglas, I.S., Jaeschke, R., et al. (2013). Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit. Care Med. 41, 580-637. https://doi.org/10.1097/CCM.0b013e31827e83af
- den Brok, M.H., Raaijmakers, T.K., Collado-Camps, E., and Adema, G.J. (2018). Lipid droplets as immune modulators in myeloid cells. Trends Immunol. 39, 380-392. https://doi.org/10.1016/j.it.2018.01.012
- Donnino, M.W., Andersen, L.W., Chase, M., Berg, K.M., Tidswell, M., Giberson, T., Wolfe, R., Moskowitz, A., Smithline, H., Ngo, L., et al. (2016). Randomized, double-blind, placebo-controlled trial of thiamine as a metabolic resuscitator in septic shock: a pilot study. Crit. Care Med. 44, 360-367.
- Fleischmann, C., Scherag, A., Adhikari, N.K., Hartog, C.S., Tsaganos, T., Schlattmann, P., Angus, D.C., Reinhart, K., and International Forum of Acute Care Trialists (2016). Assessment of global incidence and mortality of hospital-treated sepsis. Current estimates and limitations. Am. J. Respir. Crit. Care Med. 193, 259-272. https://doi.org/10.1164/rccm.201504-0781OC
- Friedman, E.A., Ogletree, M.L., Haddad, E.V., and Boutaud, O. (2015). Understanding the role of prostaglandin E2 in regulating human platelet activity in health and disease. Thromb. Res. 136, 493-503. https://doi.org/10.1016/j.thromres.2015.05.027
- Hanberry, B.S., Berger, R., and Zastre, J.A. (2014). High-dose vitamin B1 reduces proliferation in cancer cell lines analogous to dichloroacetate. Cancer Chemother. Pharmacol. 73, 585-594. https://doi.org/10.1007/s00280-014-2386-z
- Infantino, V., Iacobazzi, V., Menga, A., Avantaggiati, M.L., and Palmieri, F. (2014). A key role of the mitochondrial citrate carrier (SLC25A1) in TNFalpha- and IFNgamma-triggered inflammation. Biochim. Biophys. Acta 1839, 1217-1225. https://doi.org/10.1016/j.bbagrm.2014.07.013
- Infantino, V., Pierri, C.L., and Iacobazzi, V. (2019). Metabolic routes in inflammation: the citrate pathway and its potential as therapeutic target. Curr. Med. Chem. 26, 7104-7116. https://doi.org/10.2174/0929867325666180510124558
- Liu, Y., Jennings, N.L., Dart, A.M., and Du, X.J. (2012). Standardizing a simpler, more sensitive and accurate tail bleeding assay in mice. World J. Exp. Med. 2, 30-36. https://doi.org/10.5493/wjem.v2.i2.30
- MacPherson, S., Horkoff, M., Gravel, C., Hoffmann, T., Zuber, J., and Lum, J.J. (2017). STAT3 regulation of citrate synthase is essential during the initiation of lymphocyte cell growth. Cell Rep. 19, 910-918. https://doi.org/10.1016/j.celrep.2017.04.012
- McCall, C.E., Zabalawi, M., Liu, T., Martin, A., Long, D.L., Buechler, N.L., Arts, R.J.W., Netea, M., Yoza, B.K., Stacpoole, P.W., et al. (2018). Pyruvate dehydrogenase complex stimulation promotes immunometabolic homeostasis and sepsis survival. JCI Insight 3, e99292. https://doi.org/10.1172/jci.insight.99292
- Merz, T.M., Pereira, A.J., Schurch, R., Schefold, J.C., Jakob, S.M., Takala, J., and Djafarzadeh, S. (2017). Mitochondrial function of immune cells in septic shock: a prospective observational cohort study. PLoS One 12, e0178946. https://doi.org/10.1371/journal.pone.0178946
- Nayak, M.K., Dhanesha, N., Doddapattar, P., Rodriguez, O., Sonkar, V.K., Dayal, S., and Chauhan, A.K. (2018). Dichloroacetate, an inhibitor of pyruvate dehydrogenase kinases, inhibits platelet aggregation and arterial thrombosis. Blood Adv. 2, 2029-2038. https://doi.org/10.1182/bloodadvances.2018022392
- Nemzek, J.A., Xiao, H.Y., Minard, A.E., Bolgos, G.L., and Remick, D.G. (2004). Humane endpoints in shock research. Shock 21, 17-25.
- Nuzzo, E., Berg, K.M., Andersen, L.W., Balkema, J., Montissol, S., Cocchi, M.N., Liu, X., and Donnino, M.W. (2015). Pyruvate dehydrogenase activity is decreased in the peripheral blood mononuclear cells of patients with sepsis. A prospective observational trial. Ann. Am. Thorac. Soc. 12, 1662-1666.
- O'Neill, L.A. (2014). Glycolytic reprogramming by TLRs in dendritic cells. Nat. Immunol. 15, 314-315. https://doi.org/10.1038/ni.2852
- Singer, M. (2014). The role of mitochondrial dysfunction in sepsis-induced multi-organ failure. Virulence 5, 66-72. https://doi.org/10.4161/viru.26907
- Van den Bossche, J., O'Neill, L.A., and Menon, D. (2017). Macrophage immunometabolism: where are we (going)? Trends Immunol. 38, 395-406. https://doi.org/10.1016/j.it.2017.03.001
- Wang, H. and Ma, S. (2008). The cytokine storm and factors determining the sequence and severity of organ dysfunction in multiple organ dysfunction syndrome. Am. J. Emerg. Med. 26, 711-715. https://doi.org/10.1016/j.ajem.2007.10.031
- Woolum, J.A., Abner, E.L., Kelly, A., Thompson Bastin, M.L., Morris, P.E., and Flannery, A.H. (2018). Effect of thiamine administration on lactate clearance and mortality in patients with septic shock. Crit. Care Med. 46, 1747-1752. https://doi.org/10.1097/CCM.0000000000003311
- Yadav, U.C., Kalariya, N.M., Srivastava, S.K., and Ramana, K.V. (2010). Protective role of benfotiamine, a fat-soluble vitamin B1 analogue, in lipopolysaccharide-induced cytotoxic signals in murine macrophages. Free Radic. Biol. Med. 48, 1423-1434. https://doi.org/10.1016/j.freeradbiomed.2010.02.031
Cited by
- Lipid Droplets, the Central Hub Integrating Cell Metabolism and the Immune System vol.12, 2020, https://doi.org/10.3389/fphys.2021.746749