The Journal of Pediatrics of Korean Medicine (대한한방소아과학회지)

The Association of Korean Oriental Pediatrics (대한한방소아과학회)
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A Review of the Experimental Studies on the Modulatory Effect Herbal Medicine on Gut Microbiota

한약의 장내미생물 조절 효과에 대한 국내외 실험 연구 고찰

  • Ahn, Hye Ri (Department of Pediatrics, College of Korean Medicine, Daejeon University) ;
  • Song, Ji Hyun (Department of Pediatrics, College of Korean Medicine, Daejeon University) ;
  • Lee, Hye Lim (Department of Pediatrics, College of Korean Medicine, Daejeon University)
  • 안혜리 (대전대학교 한의과대학 소아과학교실) ;
  • 송지현 (대전대학교 한의과대학 소아과학교실) ;
  • 이혜림 (대전대학교 한의과대학 소아과학교실)
  • Received : 2020.10.21
  • Accepted : 2020.11.23
  • Published : 2020.11.30
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Abstract

Objectives The purpose of this study is to analyze the effect of various herbal medicin on gut microbiota. Methods Electronic searches were performed using NDSL, OASIS, KISS, KMBASE, K-portal, Pub med, Cochrane, CNKI. Results we analyzed 25 experimental studies on the effect of herbal medicine on microbiota. Diabetes, obesity, inflammatory bowel disease have been frequently studied in micobiota-related disease. The most common experimental animal model used in the studies C57BL/7 mouse. Among the studies wherein single herbal medication were used, Gynostemma pentaphyllum was most commonly studies, and different herbal medications were used in the studies wherein complex herbal medications were studied. Next generation sequencing was performed using Illumina MiSeq system, and gut microbiota analysis was performed using QIIME and Ribosomal Database Project (RDP). In most studies, the herbal medicines exerted regulatory effects on gut microbiota and improved the symptoms of the experimental groups. Conclusions This review provides basic data on the correlation between korean medicine and gut microbiota, as well as information for the development of korean medicine.

Keywords

References

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