Journal of the Korea Academia-Industrial cooperation Society (한국산학기술학회논문지)

The Korea Academia-Industrial cooperation Society (한국산학기술학회)
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Meta-Analysis on the Effect of Serum Lipids Levels in Silkworm and Silkworm Pupae

누에와 누에번데기의 혈청지질에 미친 영향에 대한 메타분석

  • Kim, Eun-Joo (Department of Alternative Medicine Graduate School Kyonggi University) ;
  • Lee, So-Young (Department of Alternative Medicine Graduate School Kyonggi University) ;
  • Kim, Ae-Jung (Department of Alternative Medicine Graduate School Kyonggi University)
  • 김은주 (경기대학교 일반대학원 대체의학과) ;
  • 이소영 (경기대학교 일반대학원 대체의학과) ;
  • 김애정 (경기대학교 일반대학원 대체의학과)
  • Received : 2020.10.23
  • Accepted : 2020.11.06
  • Published : 2020.11.30
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Abstract

This study analyzed the physiological effects of silkworms and silkworm pupae on the reduction of serum lipid levels. Research data specific to silkworms and their pupae published over the last 10 years were collected and analyzed. A large effect size of 0.852 was observed in the overall results and the range of 95% confidence intervals was 0.662 to 0.999. The Q value was 23.264, the Higgin's I2 value was 92.217, indicating that each study was heterogeneous. There was no publication bias, as the corrected observed number of statistically significant effect sizes and the expected number of statistically significant effect sizes were both 0.654. The silkworm study showed a large effect size with respect to blood sugar and blood lipid reduction at 0.801 and 0.948, respectively, and LDL-cholesterol reduction at 1.371, showing a very large effect size. Aspartate transaminase / glutamic oxaloacetic transaminase (AST/GOT) was 0.768, alanine transaminase /glutamate-pyruvate transaminase (ALT/GPT) was 0.788, which was a medium effect size. The experiment period had a very large effect size of 1.170 for five to eight weeks and 1.020 for an intake of 1 to 50 mg/kg. The silkworm pupae had a large effect size of 0.991 and 0.951, respectively on blood lipids and total cholesterol reduction. The experimental period showed a very large effect size at 1.103 for more than nine weeks, and the intake showed a large effect size at 0.855 for 5001 mg/kg.

본 연구는 경제적, 사회적, 환경적으로 가치가 있는 미래의 식량자원인 곤충식품의 산업적 활용도를 높이고자 최근 10년간(2009년~2019년) 발표된 곤충식품들 중 누에와 누에번데기의 생리활성 연구자료를 수집하여 혈청 지질 수준 개선에 대한 메타분석을 실시하였다. 누에와 누에번데기 연구물의 총 편수는 20편이었으며, 총 사례 수는 261개로 산출되었다. 연구단위로 분석한 연구의 수는 총 20개였다. 전체 연구결과의 효과크기는 0.852로 큰 효과크기였으며, 95% 신뢰구간의 범위는 0.662~0.999였다. Q 값은 23.264(p<0.001), Higgin's I2 값은 92.217로 각각의 연구가 이질성이 있다고 확인되었다. 관측값과 추정치를 보정한 관측값이 0.654로 동일하게 나타나 출판편향은 없었다. 누에 연구는 혈당과 혈중지질이 각각 0.801, 0.948로 큰 효과크기였으며, 그중 LDL-콜레스테롤은 1.371로 매우 큰 효과크기였다. 간 세포 손상(AST/GOT)은 0.768, 만성 간 세포 손상(ALT/GPT)은 0.788로 중간 효과크기였다. 실험기간은 5~8주가 1.170, 섭취량은 1~50 mg/kg이 1.020으로 매우 큰 효과크기였다. 누에번데기는 혈중지질과 총 콜레스테롤이 각각 0.991, 0.951로 큰 효과크기였다. 실험기간은 9주 이상이 1.103으로 매우 큰 효과크기였으며, 섭취량은 5001 mg/kg 이상이 0.855로 큰 효과크기를 보였다.

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