DOI QR코드

DOI QR Code

A Case of Extranodal NK/T-cell Lymphoma at the Base of Tongue

혀뿌리에 발생한 림프절외 NK/T 세포 림프종 1예

  • Ha, Jung Ho (Department of Otolaryngology, Ajou University School of Medicine, Ajou University Hospital) ;
  • Han, Jae Ho (Department of Pathology, Ajou University School of Medicine, Ajou University Hospital) ;
  • Jang, Jeon Yeob (Department of Otolaryngology, Ajou University School of Medicine, Ajou University Hospital)
  • 하정호 (아주대학교 의과대학 이비인후과학교실) ;
  • 한재호 (아주대학교 의과대학 병리학과교실) ;
  • 장전엽 (아주대학교 의과대학 이비인후과학교실)
  • Received : 2020.06.23
  • Accepted : 2020.10.20
  • Published : 2020.11.30

Abstract

Extranodal Natural Killer (NK)/T-cell lymphoma, nasal type, is a subtype of non-Hodgkin lymphoma, strongly associated with Epstein-Barr virus. Extranodal NK/T-cell lymphoma mostly affects the nasal cavity and there has been no report of the disease's occurrence at the base of tongue. Here we report a case of 43-year-old man who presented with a diffuse ulcerative lesion at the base of tongue. Because the patient had oral bleeding, tracheostomy and lingual artery ligation was performed via a transcervical approach to control bleeding and protect the upper airway. We performed a deep biopsy through the lateral pharyngotomy approach, and finally, the patient was diagnosed with extranodal NK/T-cell lymphoma, nasal type. We report this rare case of extranodal NK/T cell lymphoma at the base of tongue with a literature review.

Keywords

References

  1. Tae K, Lee HS, Seo IS, Lee YS, Cho SH, Choi JH, et al. Hodgkin's and Non-Hodgkin's Lymphoma of Head and Neck. Korean Journal of Otorhinolaryngology-Head and Neck Surgery. 2003;46:324-330.
  2. Al-Hakeem DA, Fedele S, Carlos R, Porter S. Extranodal NK/T-cell lymphoma, nasal type. Oral oncology. 2007;43(1):4-14. https://doi.org/10.1016/j.oraloncology.2006.03.011
  3. Cho K-J, Cho S-G, Lee D-H. Natural killer T-cell lymphoma of the tongue. Annals of Otology, Rhinology & Laryngology. 2005;114(1):55-57. https://doi.org/10.1177/000348940511400110
  4. Hanna E, Wanamaker J, Adelstein D, Tubbs R, Lavertu P. Extranodal lymphomas of the head and neck: a 20-year experience. Archives of Otolaryngology-Head & Neck Surgery. 1997;123(12):1318-1323. https://doi.org/10.1001/archotol.1997.01900120068011
  5. Li Y-X, Fang H, Liu Q-F, Lu J, Qi S-N, Wang H, et al. Clinical features and treatment outcome of nasal-type NK/T-cell lymphoma of Waldeyer ring. Blood, The Journal of the American Society of Hematology. 2008; 112 (8):3057-3064.
  6. Li Y-X, Liu Q-F, Fang H, Qi S-N, Wang H, Wang W-H, et al. Variable clinical presentations of nasal and Waldeyer ring natural killer/T-cell lymphoma. Clinical Cancer Research. 2009;15(8):2905-2912. https://doi.org/10.1158/1078-0432.CCR-08-2914
  7. Tse E, Kwong Y-L. The diagnosis and management of NK/T-cell lymphomas. Journal of hematology & oncology. 2017;10(1):85. https://doi.org/10.1186/s13045-017-0452-9
  8. Au W-y, Weisenburger DD, Intragumtornchai T, Nakamura S, Kim W-S, Sng I, et al. Clinical differences between nasal and extranasal natural killer/T-cell lymphoma: a study of 136 cases from the International Peripheral T-Cell Lymphoma Project. Blood, The Journal of the American Society of Hematology. 2009;113(17):3931-3937.
  9. Wu X, Li P, Zhao J, Yang X, Wang F, Yang Y, et al. A clinical study of 115 patients with extranodal natural killer/T-cell lymphoma, nasal type. Clinical Oncology. 2008;20(8):619-625. https://doi.org/10.1016/j.clon.2008.05.011
  10. Azad FJ, Delavarian Z, Hatami M, Rahimi H, Abdolvahed MR. Extranodal NK/T cell lymphoma with destruction of the uvulae: a case report. Iranian journal of otorhinolaryngology. 2017;29(91):101.
  11. Tlholoe MM, Kotu M, Khammissa RA, Bida M, Lemmer J, Feller L. Extranodal natural killer/T-cell lymphoma, nasal type: 'midline lethal granuloma.'A case report. Head & face medicine. 2013;9 (1):4. https://doi.org/10.1186/1746-160X-9-4
  12. Li S, Feng X, Li T, Zhang S, Zuo Z, Lin P, et al. Extranodal NK/T-cell lymphoma, nasal type: a report of 73 cases at MD Anderson Cancer Center. The American journal of surgical pathology. 2013;37(1):14-23. https://doi.org/10.1097/PAS.0b013e31826731b5
  13. Anderson JR, Armitage JO, Weisenburger DD, Project N-HsLC. Epidemiology of the non-Hodgkin's lymphomas: Distributions of the major subtypes differ by geographic locations. Annals of oncology. 1998;9(7):717-720. https://doi.org/10.1023/A:1008265532487
  14. Cheung MM, Chan JK, Wong K-F. Natural killer cell neoplasms: a distinctive group of highly aggressive lymphomas/leukemias. Seminars in hematology; 2003. Elsevier. p.221-232.
  15. Kwong Y-L, Kim WS, Lim ST, Kim SJ, Tang T, Tse E, et al. SMILE for natural killer/T-cell lymphoma: analysis of safety and efficacy from the Asia Lymphoma Study Group. Blood, The Journal of the American Society of Hematology. 2012;120(15):2973-2980.
  16. Kim SJ, Yoon SE, Kim WS. Treatment of localized extranodal NK/T cell lymphoma, nasal type: a systematic review. Journal of hematology & oncology. 2018;11(1):140. https://doi.org/10.1186/s13045-018-0687-0
  17. Kim GE, Lee S-w, Chang SK, Park HC, Pyo HR, Kim JH, et al. Combined chemotherapy and radiation versus radiation alone in the management of localized angiocentric lymphoma of the head and neck. Radiotherapy and Oncology. 2001;61(3):261-269. https://doi.org/10.1016/S0167-8140(01)00428-5
  18. Horwitz SM, Ansell SM, Ai WZ, Barnes J, Barta SK, Choi M, et al. NCCN guidelines insights: T-cell lymphomas, version 2.2018. Journal of the National Comprehensive Cancer Network. 2018;16(2):123-135. https://doi.org/10.6004/jnccn.2018.0007