DOI QR코드

DOI QR Code

Curcumin supplementation and delayed onset muscle soreness (DOMS): effects, mechanisms, and practical considerations

  • Yoon, Wan-Young (Department of Health Care Exercise, Seowon University) ;
  • Lee, Kihyuk (Department of Sport Culture, Dongguk University) ;
  • Kim, Jooyoung (Office of Academic Affairs, Konkuk University)
  • Received : 2020.09.11
  • Accepted : 2020.09.27
  • Published : 2020.09.30

Abstract

[Purpose] In this literature review we aimed to investigate the effects of curcumin supplementation on delayed onset muscle soreness (DOMS), which occurs after exercise, and evaluate related parameters to propose practical recommendations for the field of exercise physiology. [Methods] Experimental studies conducted on curcumin supplementation and DOMS were systematically reviewed to determine (1) the effect of curcumin supplementation on DOMS, (2) potential mechanisms by which curcumin supplementation may attenuate DOMS, and (3) practical considerations for curcumin supplementation. [Results] While several studies have reported that curcumin supplementation attenuates DOMS after exercise, others have reported that curcumin supplementation has no effect on DOMS. Several mechanisms have been proposed by which curcumin supplementation may attenuate DOMS; the most probable of which is a reduction in inflammatory response. Other potential mechanisms include modulation of transient receptor potential vanilloid 1 (TRPV1) or changes in post-exercise capillary lactate levels; these require further examination. The usual recommended dose of curcumin is 150-1500 mg daily (sometimes up to 5 g), divided into 2-3 portions and taken before and after exercise. It is not necessary to take curcumin together with piperine. [Conclusion] Although conflicting results regarding the effects of curcumin supplementation on DOMS exist in literature, it may be considered as a method of nutritional intervention for reducing post-exercise DOMS.

Keywords

Acknowledgement

This work was supported by the Ministry of Education of the Republic of Korea and the National Research Foundation of Korea (NRF-2019R1I1A1A01063940).

References

  1. Kim J, So WY. Effects of acute grape seed extract supplementation on muscle damage after eccentric exercise: a randomized, controlled clinical trial. J Exerc Sci Fit. 2019;17:77-9. https://doi.org/10.1016/j.jesf.2019.01.001
  2. Mizumura K, Taguchi T. Delayed onset muscle soreness: involvement of neurotrophic factors. J Physiol Sci. 2016;66:43-52. https://doi.org/10.1007/s12576-015-0397-0
  3. Cheung K, Hume P, Maxwell L. Delayed onset muscle soreness: treatment strategies and performance factors. Sports Med. 2003;33:145-64. https://doi.org/10.2165/00007256-200333020-00005
  4. Mizumura K, Taguchi T. Delayed onset muscle soreness: involvement of neurotrophic factors. J Physiol Sci. 2016;66:43-52. https://doi.org/10.1007/s12576-015-0397-0
  5. Ota H, Katanosaka K, Murase S, Kashio M, Tominaga M, Mizumura K. TRPV1 and TRPV4 play pivotal roles in delayed onset muscle soreness. PLoS One. 2013;8:65751.
  6. Smith LL. Acute inflammation: the underlying mechanism in delayed onset muscle soreness?. Med Sci Sports Exerc. 1991;23:542-51.
  7. Urai H, Murase S, Mizumura K. Decreased nerve growth factor upregulation is a mechanism for reduced mechanical hyperalgesia after the second bout of exercise in rats. Scand J Med Sci Sports. 2013;23:96-101. https://doi.org/10.1111/j.1600-0838.2011.01361.x
  8. Armstrong RB. Mechanisms of exercise-induced delayed onset muscular soreness: a brief review. Med Sci Sports Exerc. 1984;16:529-38.
  9. Harty PS, Cottet ML, Malloy JK, Kerksick CM. Nutritional and supplementation strategies to prevent and attenuate exercise-induced muscle damage: a brief review. Sports Med Open. 2019;5:1. https://doi.org/10.1186/s40798-018-0176-6
  10. Seriken AM, Cencoglu C, Kayatekin MB. The effect of eccentric exercise-induced delayed-onset muscle soreness on positioning sense and shooting percentage in wheelchair basketball players. Balkan Med J. 2013;30:382-6. https://doi.org/10.5152/balkanmedj.2013.007
  11. Connolly DA, Sayers SP, McHugh MP. Treatment and prevention of delayed onset muscle soreness. J Strength Cond Res. 2003;17:197-208. https://doi.org/10.1519/1533-4287(2003)017<0197:TAPODO>2.0.CO;2
  12. Howatson G, van Someren KA. The prevention and treatment of exercise-induced muscle damage. Sports Med. 2008;38:483-503. https://doi.org/10.2165/00007256-200838060-00004
  13. Kim J, Lee J. A review of nutritional intervention on delayed onset muscle soreness. Part I. J Exerc Rehabil. 2014;10:349-56. https://doi.org/10.12965/jer.140179
  14. Owens DJ, Twist C, Cobley JN, Howatson G, Close GL. Exercise-induced muscle damage: what is it, what causes it and what are the nutritional solutions?. Eur J Sport Sci. 2019;19:71-85. https://doi.org/10.1080/17461391.2018.1505957
  15. Pulido-Moran M, Moreno-Fernandez J, Ramirez-Tortosa C, Ramirez-Tortosa M. Curcumin and health. Molecules. 2016;21:264. https://doi.org/10.3390/molecules21030264
  16. Cheppudira B, Fowler M, McGhee L, Greer A, Mares A, Petz L, Devore D, Loyd DR, Clifford JL. Curcumin: a novel therapeutic for burn pain and wound healing. Expert Opin Investig Drugs. 2013;22:1295-303. https://doi.org/10.1517/13543784.2013.825249
  17. Sun J, Chen F, Braun C, Zhou YQ, Rittner H, Tian YK, Cai XY, Ye DW. Role of curcumin in the management of pathological pain. Phytomedicine. 2018;48:129-40. https://doi.org/10.1016/j.phymed.2018.04.045
  18. Mallard AR, Briskey D, Richards BExSSc A, Rao A. Curcumin improves delayed onset muscle soreness and postexercise lactate accumulation. J Diet Suppl. 2020;1-12.
  19. Nicol LM, Rowlands DS, Fazakerly R, Kellett J. Curcumin supplementation likely attenuates delayed onset muscle soreness (DOMS). Eur J Appl Physiol. 2015;115:1769-77. https://doi.org/10.1007/s00421-015-3152-6
  20. Tanabe Y, Chino K, Ohnishi T, Ozawa H, Sagayama H, Maeda S, Takahashi H. Effects of oral curcumin ingested before or after eccentric exercise on markers of muscle damage and inflammation. Scand J Med Sci Sports. 2019;29:524-34. https://doi.org/10.1111/sms.13373
  21. Carfagno DG, Hendrix JC 3rd. Overtraining syndrome in the athlete: current clinical practice. Curr Sports Med Rep. 2014;13:45-51. https://doi.org/10.1249/JSR.0000000000000027
  22. Basham SA, Waldman HS, Krings BM, Lamberth J, Smith JW, McAllister MJ. Effect of curcumin supplementation on exercise-induced oxidative stress, inflammation, muscle damage, and muscle soreness. J Diet Suppl. 2020;17:401-14. https://doi.org/10.1080/19390211.2019.1604604
  23. Drobnic F, Riera J, Appendino G, Togni S, Franceschi F, Valle X, Tur J. Reduction of delayed onset muscle soreness by a novel curcumin delivery system (Meriva®): a randomised, placebo-controlled trial. J Int Soc Sports Nutr. 2014;11:31. https://doi.org/10.1186/1550-2783-11-31
  24. Amalraj A, Divya C, Gopi S. The Effects of bioavailable curcumin (Cureit) on delayed onset muscle soreness induced by eccentric continuous exercise: a randomized, placebo-controlled, double-blind clinical study. J Med Food. 2020;23:545-53. https://doi.org/10.1089/jmf.2019.4533
  25. Nakhostin-Roohi B, Nasirvand Moradlou A, Mahmoodi Hamidabad S, Ghanivand B. The effect of curcumin supplementation on selected markers of delayed onset muscle soreness (DOMS). Ann Appl Sport Sci. 2016;4:25-31. https://doi.org/10.18869/acadpub.aassjournal.4.2.25
  26. Tanabe Y, Chino K, Sagayama H, Lee HJ, Ozawa H, Maeda S, Takahashi H. Effective timing of curcumin ingestion to attenuate eccentric exercise-induced muscle soreness in men. J Nutr Sci Vitaminol (Tokyo). 2019;65:82-9. https://doi.org/10.3177/jnsv.65.82
  27. Cardaci TD, Machek SB, Wilburn DT, Hwang PS, Willoughby DS. Ubiquitin proteasome system activity is suppressed by curcumin following exercise-induced muscle damage in human skeletal muscle. J Am Coll Nutr. 2020;1-11.
  28. Delecroix B, Abaidia AE, Leduc C, Dawson B, Dupont G. Curcumin and piperine supplementation and recovery following exercise induced muscle damage: a randomized controlled trial. J Sports Sci Med. 2017;16:147-53.
  29. McFarlin BK, Venable AS, Henning AL, Sampson JN, Pennel K, Vingren JL, Hill DW. Reduced inflammatory and muscle damage biomarkers following oral supplementation with bioavailable curcumin. BBA Clin. 2016;5:72-8. https://doi.org/10.1016/j.bbacli.2016.02.003
  30. Tanabe Y, Maeda S, Akazawa N, Zempo-Miyaki A, Choi Y, Ra SG, Imaizumi A, Otsuka Y, Nosaka, K. Attenuation of indirect markers of eccentric exercise-induced muscle damage by curcumin. Eur J Appl Physiol. 2015;115:1949-57. https://doi.org/10.1007/s00421-015-3170-4
  31. Jager R, Purpura M, Kerksick CM. Eight weeks of a high dose of curcumin supplementation may attenuate performance decrements following muscle-damaging exercise. Nutrients. 2019;11:1692. https://doi.org/10.3390/nu11071692
  32. Chazaud B. Inflammation during skeletal muscle regeneration and tissue remodeling: application to exercise-induced muscle damage management. Immunol Cell Biol. 2016;94:140-5. https://doi.org/10.1038/icb.2015.97
  33. Kanda K, Sugama K, Hayashida H, Sakuma J, Kawakami Y, Miura S, Yoshioka H, Mori Y, Suzuki K. Eccentric exerciseinduced delayed-onset muscle soreness and changes in markers of muscle damage and inflammation. Exerc Immunol Rev. 2013;19:72-85.
  34. Olivera A, Moore TW, Hu F, Brown AP, Sun A, Liotta DC, Snyder JP, Yoon Y, Shim H, Marcus AI, Miller AH, Pace TW. Inhibition of the NF-κB signaling pathway by the curcumin analog, 3,5-Bis(2-pyridinylmethylidene)-4-piperidone (EF31): anti-inflammatory and anti-cancer properties. Int Immunopharmacol. 2012;12:368-77. https://doi.org/10.1016/j.intimp.2011.12.009
  35. Yahfoufi N, Alsadi N, Jambi M, Matar C. The immunomodulatory and anti-inflammatory role of polyphenols. Nutrients. 2018;10:1618. https://doi.org/10.3390/nu10111618
  36. Davis JM, Murphy EA, Carmichael MD, Zielinski MR, Groschwitz CM, Brown AS, Gangemi JD, Ghaffar A, Mayer EP. Curcumin effects on inflammation and performance recovery following eccentric exercise-induced muscle damage. Am J Physiol Regul Integr Comp Physiol. 2007;292:2168-73.
  37. Proske U, Morgan DL. Muscle damage from eccentric exercise: mechanism, mechanical signs, adaptation and clinical applications. J Physiol. 2001;537:333-45. https://doi.org/10.1111/j.1469-7793.2001.00333.x
  38. Leamy AW, Shukla P, McAlexander MA, Carr MJ, Ghatta S. Curcumin ((E,E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) activates and desensitizes the nociceptor ion channel TRPA1. Neurosci Lett. 2011;503:157-62. https://doi.org/10.1016/j.neulet.2011.07.054
  39. Yeon KY, Kim SA, Kim YH, Lee MK, Ahn DK, Kim HJ, Kim JS, Jung SJ, Oh SB. Curcumin produces an antihyperalgesic effect via antagonism of TRPV1. J Dent Res. 2010;89:170-4. https://doi.org/10.1177/0022034509356169
  40. Fitzgerald GK, Rothstein JM, Mayhew TP, Lamb RL. Exercise-induced muscle soreness after concentric and eccentric isokinetic contractions. Phys Ther. 1991;71:505-13. https://doi.org/10.1093/ptj/71.7.505
  41. Schwane JA, Watrous BG, Johnson SR, Armstrong RB. Is lactic acid related to delayed-onset muscle soreness?. Phys Sportsmed. 1983;11:124-31. https://doi.org/10.1080/00913847.1983.11708485
  42. Newton MJ, Morgan GT, Sacco P, Chapman DW, Nosaka K. Comparison of responses to strenuous eccentric exercise of the elbow flexors between resistance-trained and untrained men. J Strength Cond Res. 2008;22:597-607. https://doi.org/10.1519/jsc.0b013e3181660003
  43. Fernandez-Lazaro D, Mielgo-Ayuso J, Seco Calvo J, Cordova Martinez A, Caballero Garcia A, Fernandez-Lazaro CI. Modulation of exercise-induced muscle damage, inflammation, and oxidative markers by curcumin supplementation in a physically active population: a systematic review. Nutrients. 2020;12:501. https://doi.org/10.3390/nu12020501