Journal of Ginseng Research

The Korean Society of Ginseng (고려인삼학회)
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Ginsenoside-Rp1 inhibits radiation-induced effects in lipopolysaccharide-stimulated J774A.1 macrophages and suppresses phenotypic variation in CT26 colon cancer cells

  • Baik, Ji Sue (Research Center, Dongnam Institute of Radiological & Medical Sciences) ;
  • Seo, You Na (Research Center, Dongnam Institute of Radiological & Medical Sciences) ;
  • Yi, Joo Mi (Department of Microbiology and Immunology, College of Medicine, Inje University) ;
  • Rhee, Man Hee (Department of Veterinary Medicine, College of Veterinary Medicine, Kyungpook National University) ;
  • Park, Moon-Taek (Research Center, Dongnam Institute of Radiological & Medical Sciences) ;
  • Kim, Sung Dae (Research Center, Dongnam Institute of Radiological & Medical Sciences)
  • Received : 2019.02.21
  • Accepted : 2020.01.21
  • Published : 2020.11.15
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Abstract

This study investigated the inhibitory effect of ginsenoside-Rp1 (G-Rp1) on the ionizing radiation (IR)-induced response in lipopolysaccharide (LPS)-stimulated macrophages and its effects on the malignancy of tumor cells. G-Rp1 inhibited the activation of IR-induced DNA damage-related signaling molecules and thereby interfered with the IR-increased production of nitric oxide (NO) and interleukin (IL)-1β. The inhibitory effect of G-Rp1 increased the survival rate of mice inoculated with CT26 colon cancer cells by suppressing the phenotypic variation of tumor cells induced by conditioned medium obtained from IR- and LPS-treated J774A.1 macrophages.

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References

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